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    Title: The locust genome provides insight into swarm formation and long-distance flight
    Author: Xian-hui Wang,#X. Fang,Peng-cheng Yang,#X. Jiang,Feng Jiang,De-jian Zhao,Bo-lei Li,Feng Cui,Jia-ning Wei,Chuan Ma,Yun-dan Wang,Jing He,Yuan Luo,Zhi-feng Wang,Xiao-jiao Guo,Wei Guo, X. Wang, Y. Zhang, M. Yang,Shu-guang Hao,Bin Chen,Zong-yuan Ma,Dan Yu, #Z. Xiong, #Y. Zhu, #D. Fan, #L. Han, #B. Wang, #Y. Chen, #J. Wang, #L. Yang, #W. Zhao, #Y. Feng, #G. Chen,#J. Lian, #Q. Li,#Z. Huang, #X. Yao, #N. Lv,#G. Zhang,#Y. Li,#J. Wang,#Jun Wang, #B. Zhu,Le Kang*
    Abstract: Locusts are one of the world’s most destructive agricultural pests and represent a useful model system in entomology. Here we present a draft 6.5 Gb genome sequence of Locusta migratoria, which is the largest animal genome sequenced so far. Our findings indicate that the large genome size of L. migratoria is likely to be because of transposable element proliferation combined with slow rates of loss for these elements. Methylome and transcriptome analyses reveal complex regulatory mechanisms involved in microtubule dynamic-mediated synapse plasticity during phase change. We find significant expansion of gene families associated with energy consumption and detoxification, consistent with long-distance flight capacity and phytophagy. We report hundreds of potential insecticide target genes, including cys-loop ligand-gated ion channels, G-protein-coupled receptors and lethal genes. The L. migratoria genome sequence offers new insights into the biology and sustainable management of this pest species, and will promote its wide use as a model system.
    Corresponding author: Le Kang
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    PubYear: 2014
    Volume: 5
    Issue: 2957
    Journal: Nature Communications
    The full text link:
    URL: http://www.nature.com/ncomms/2014/140114/ncomms3957/abs/ncomms3957.html