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    Name:
    CUI Feng
    Subject:
    Zoology
    Tel/Fax:
    +86-10-64807218  /  +86-10-64807099
    E-mail:
    cuif@ioz.ac.cn
    Address:
    The State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
    More:
    Genomics of vector insect and virus      

    Resume:

    July 2006 – December 2008: Assistant Professor, Institute of Zoology, Chinese Academy of Sciences
    July 2007 –December 2008: Associate Research, Department of Biochemistry, Kansas State University
    January 2009 - December 2016: Associate Professor, Institute of Zoology, Chinese Academy of Sciences
    January 2017- present: Professor, Institute of Zoology, Chinese Academy of Sciences

    Education:
    September 2003 to July 2006: Ph.D. in Zoology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. Direction: Molecular genetics of insecticide resistance in insects
    September 1999 to July 2002: Shandong Agricultural University, Tai'an, China. Master in Agronomy. Direction: Insect physiology
    September 1995 to July 1999: Shandong Agricultural University, Tai’an, China. Bachelor in Agronomy. Direction: Forestry


    Research Interest:

    My main research direction is exploring the molecular mechanisms of the interactions among vector insects, plant virus and plants. This includes: (1) the interaction mechanisms of persistent-propagative plant viruses with vector insects; (2) the variation of plant viruses during the transmission between vector insect and host plant; (3) the function of saliva proteins in the transmission of persistent-propagative plant viruses and the adaptation of vector insects to their host plants.
    1. The interaction mechanisms of persistent-propagative plant viruses with vector insects. Rice stripe virus (RSV) causes severe damage to rice in temperate and subtropical regions, and is mainly transmitted by Laodelphax striatellus, the small brown plant hopper (SBPH) in a persistent, circulative-propagative manner. Our objective is to identify key genes and proteins of SBPH interacting with viral proteins or regulating viral gene expression, thus influencing RSV incubation in SBPH, transmission and pathogenicity in plants. These proteins or genes are involved in kinds of signal pathways and immune system.
    2. The variation of plant viruses during the transmission between vector insect and host plant. We explore the variation of viral genomes and protein modifications when RSV infects vector insect and host plant. Identify the key genomic characteristics adapting to the two hosts.
    3. The function of saliva proteins in the transmission of persistent-propagative plant viruses and the adaptation of vector insects to their host plants. Salivary gland is the key organ for piercing-sucking insects to recognize and accept host plants. Continuous production of watery saliva occurs as piercing-sucking insects probe sieve elements and ingest phloem sap from individual sieve elements. Insect saliva is predicted to contain proteins that modulate plant defenses and facilitate feeding. In recent years, we explore the function of individual protein-effectors in aphid saliva, trying to answer how the genes or proteins in salivary glands regulate the adaptation of aphids to their host plants. At the same time, we also explore the functions of saliva proteins of SBPH in the transmission of RSV and the adaptation of SBPH to host plants.


    Public Services:

    Awards and Honors:

    Research Grants:

    Selected Publication:

    Representative Achievements:

    Lu H#, Zhu J#, Yu J, Li Q, Luo L, Cui F*. 2022. Key role of exportin 6 in exosome-mediated viral transmission from insect vectors to plants. Proc. Natl. Acad. Sci. U.S.A. 119(36): e2207848119.

    Ma Y#, Lu H#, Wang W, Zhu J, Zhao Wan, Cui F*. 2021. Membrane association of importin α facilitates viral entry into salivary gland cells of vector insects. Proc. Natl. Acad. Sci. U.S.A. 118 (30): e2103393118.

    Zhao W#, Zhu JJ#, Lu H, Zhu JM, Jiang F, Wang W, Luo L, Kang L, Cui F*. 2022. The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication. Protein Cell. 13: 360-378.

    Zhao W, Yu J, Jiang F, Wang W, Kang L, Cui F*. 2021. Coordination between terminal variation of the viral genome and insect microRNAs regulates rice stripe virus replication in insect vectors. PLoS Pathogens. 17: e1009424.

    Zhao W#, Xu Z#, Zhang X, Yang M, Kang L*, Liu R*, Cui F*. 2018. Genomic variations in the 3'-termini of Rice stripe virus in the rotation between vector insect and host plant. New Phytologist. 219: 1085-1096.

     

    1. Zhao W#, Wang W#, Xiao Y, Cui F*. 2023. c-Jun regulates flotillin 2 transcription to benefit viral accumulation in insect vectors. Insect Biochemistry and Molecular Biology. 152:103894.
    2. Zhao W, Li Q, Sun M, Xiao Y, Cui F*. 2022. Interaction between endogenous microRNAs and virus-derived small RNAs controls viral replication in insect vectors. PLoS Pathogens. 18: e1010709.
    3. Tong L#, Chen X#, Wang W#, Xiao Y, Yu J, Lu H, Cui F*. 2022. Alternative splicing landscape of small brown planthopper and different response of JNK2 isoforms to rice stripe virus infection. Journal of Virology. 96: e0171521. Doi: 10.1128/JVI.01715-21.
    4. Lu H, Li J, Yang P, Jiang F, Liu H, Cui F*. 2022. Mutation in the RNA-dependent RNA polymerase of a symbiotic virus is associated with the adaptability of the viral host. Frontiers in Microbiology. 13: 883436.
    5. Wang W#, Qiao L#, Lu H, Chen X, Wang X, Yu J, Zhu J, Xiao Y, Ma Y, Wu Y, Zhao W, Cui F*. 2022. Flotillin 2 facilitates the infection of a plant virus in the gut of insect vector. Journal of Virology. 96: e0214021.
    6. Ma Y#, Lu H#, Wang W, Zhu J, Zhao Wan, Cui F*. 2021. Membrane association of importin α facilitates viral entry into salivary gland cells of vector insects. Proc. Natl. Acad. Sci. U.S.A. 118 (30): e2103393118.
    7. Zhao W, Yu J, Jiang F, Wang W, Kang L, Cui F*. 2021. Coordination between terminal variation of the viral genome and insect microRNAs regulates rice stripe virus replication in insect vectors. PLoS Pathogens. 17: e1009424. Doi:10.1371/journal.ppat.1009424.
    8. Zhao W#, Zhu JJ#, Lu H, Zhu JM, Jiang F, Wang W, Luo L, Kang L, Cui F*. 2021. The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication. Protein & Cell. DOI: 10.1007/s13238-021-00822-1.
    9. Xiao Y#, Li Q#, Wang W, Fu Y, Cui F*. 2021. Regulation of RNA interference pathways in the insect vector Laodelphax striatellus by viral proteins of rice stripe virus. Viruses. 13: 1591.
    10. Zhu J, Eid FE, Tong L, Zhao W, Wang W, Heath LS, Kang L, Cui F*. 2021. Characterization of protein-protein interactions between rice viruses and vector insects. Insect Science. 28: 976-986.
    11. Chen X, Yu J, Wang W, Lu H, Kang L*, Cui F*. 2020. A plant virus ensures viral stability in the hemolymph of vector insects through suppressing prophenoloxidase activation. mBio. 11: e01453-20. Doi:10.1128/mBio.01453-20.
    12. Zhao W#, Li Q#, Cui F*. 2020. Potential functional pathways of plant RNA virus-derived small RNAs in a vector insect. Methods. 183: 38-42.
    13. Lu H, Zhu J, Yu J, Chen X, Kang L*, Cui F*. 2020. A symbiotic virus facilitates aphid adaptation to host plants by suppressing jasmonic acid responses. Molecular Plant-Microbe Interactions. 33: 55-65.
    14. Li S, Jiang F, Lu H, Kang X, Wang Y, Zou Z, Wen D, Zheng A, Liu C, Liu Q, Kang L, Xia Q*, Cui F*. 2020. Mosquito diversity and population genetic structure of six mosquito species from Hainan Island. Frontiers in Genetics. 11: 602863. doi: 10.3389/fgene.2020.602863.
    15. Zhao W#, Wang Q#, Xu Z, Liu R, Cui F*. 2019. Distinct replication and gene expression strategies of the Rice stripe virus in vector insects and host plants. Journal of General Virology. 100: 877-888.
    16. Zhao W#, Wang Q#, Xu Z#, Liu R, Cui F*. 2019. Immune responses induced by different genotypes of the disease-specific protein of Rice stripe virus in the vector insect. Virology. 527: 122-131.
    17. Wang X#, Wang W#, Zhang W, Li J, Cui F*, Qiao L*. 2019. Immune function of an angiotensin-converting enzyme against Rice stripe virus infection in a vector insect. Virology. 533: 137-144.
    18. Li J#, Zhao W#, Wang W, Zhang L, Cui F*. 2019. Evaluation of Rice stripe virus transmission efficiency by quantification of viral load in the saliva of insect vector. Pest Management Science. 75: 1979-1985.
    19. Cui N#, Lu H#, Wang T, Zhang W, Kang L*, Cui F*. 2019. Armet, an aphid effector protein, induces pathogen resistance in plants by promoting the accumulation of salicylic acid. Philosophical Transactions of the Royal Society B-Biological Sciences. 374: 20180314.
    20. Zhao W#, Xu Z#, Zhang X, Yang M, Kang L*, Liu R*, Cui F*. 2018. Genomic variations in the 3'-termini of Rice stripe virus in the rotation between vector insect and host plant. New Phytologist. 219: 1085-1096.
    21. Yang M#, Xu Z#, Zhao W#, Liu Q, Li Q, Lu L, Liu R*, Zhang X*, Cui F*. 2018. Rice stripe virus-derived siRNAs play different regulatory roles in rice and in the insect vector Laodelphax striatellus. BMC Plant Biology. 18: 219.
    22. Zhu J#, Jiang F#, Wang X, Yang P, Bao Y, Zhao W, Wang W, Lu H, Wang Q, Cui N, Li J, Chen X, Luo L, Yu J, Kang L*, Cui F*. 2017. Genome sequence of the small brown planthopper Laodelphax striatellus. GigaScience, 6:1-12. doi: 10.1093/gigascience/gix109.
    23. Wang W#, Zhao W#, Li J#, Luo L, Kang L*, Cui F*. 2017. The c-Jun N-terminal kinase pathway of a vector insect is activated by virus capsid protein and promotes viral replication. eLife. 6: e26591. DOI: 10.7554/eLife.26591.
    24. Zhang L#, Lu H#, Guo K#, Yao S, Cui F*. 2017. Insecticide resistance status and detoxification enzymes of wheat aphids Sitobion avenae and Rhopalosiphum padi. Science China Life Sciences. 60: 927-930.
    25. Guo K, Yang P, Chen J, Lu H, Cui F*. 2017. Transcriptomic responses of three aphid species to chemical insecticide stress. Science China Life Sciences. 60: 931-934.
    26. Cui N#, Yang P#, Guo K, Kang L*, Cui F*. 2017. Large-scale gene expression reveals different adaptations of Hyalopterus persikonus to winter and summer host plants. Insect Science, 24, 431-442.
    27. Zhao W, Yang P, Kang L*, Cui F*. 2016. Different pathogenicities of rice stripe virus from the insect vector and from viruliferous plants. New Phytologist. 210: 196-207.
    28. Zhao W, Lu L, Yang P, Cui N, Kang L*, Cui F*. 2016. Organ-specific transcriptome response of the small brown planthopper toward rice stripe virus. Insect Biochemistry and Molecular Biology, 70: 60-72.
    29. Cui F#, Zhao W#, Luo L, Kang L. 2016. Rice responses and resistance to planthopper-borned viruses at transcriptomic and proteomic levels. Current Issues in Molecular Biology. 19: 43-52.
    30. Lu H, Xu Y, Cui F*. 2016. Phylogenetic analysis of the ATP-binding cassette transporter family in three mosquito species. Pesticide Biochemistry and Physiology. 132: 118-124.
    31. Lu H, Yang P, Xu Y, Luo L, Zhu J, Cui N, Kang L*, Cui F*. 2016. Performances of survival, feeding behavior, and gene expression in aphids reveal their different fitness to host alteration. Scientific Reports. 6:19344.
    32. Zhang F, Li Q, Chen X, Huo Y, Guo H, Song Z, Cui F, Zhang L, Fang R. 2016. Roles of the Laodelphax striatellus Down syndrome cell adhesion molecule in Rice stripe virus infection of its insect vector. Insect Molecular Biology, 25: 413-421.
    33. Pan Y, Zhu J, Luo L, Kang L*, Cui F*. 2015. High expression of a unique aphid protein in the salivary glands of Acyrthosiphon pisum. Physiological and Molecular Plant Pathology. 92: 175-180.
    34. Wang W, Dai H, Zhang Y, Chandrasekar R, Luo L, Hiromasa Y, Sheng C, Peng G, Chen S, Tomich JM, Reese J, Edwards O, Kang L, Reeck G*, Cui F*. 2015. Armet is an effector protein mediating aphid-plant interactions. FASEB Journal. 29: 2032-2045. 
    35. Wang W, Luo L, Lu H, Chen S, Kang L, Cui F*. 2015. Angiotensin-converting enzymes modulate aphid–plant interactions. Scientific Reports, 5: 8885.
    36. Cui F#*, Li M#, Chang H, Mao Y, Zhang H, Lu L, Yan S, Lang M, Liu L*, Qiao C. 2015. Carboxylesterase-mediated insecticide resistance: quantitative increase induces broader metabolic resistance than qualitative change. Pesticide Biochemistry and Physiology, 121: 88-96.
    37. Wang W, Liu S, Liu Y, Qiao C, Chen S*, Cui F*. 2015. Over-transcription of genes in a parathion-resistant strain of mosquito Culex pipiens quinquefasciatus. Insect Science, 22: 150-156.
    38. Cui F#, Wang H#, Zhang H, Kang L. 2014. Anoxic stress and rapid cold hardening enhance cold tolerance of the migratory locust. Cryobiology, 69: 243-248.
    39. Guo K, Wang W, Luo L, Chen J, Guo Y, Cui F*. 2014. Characterization of an aphid-specific, cysteine-rich protein enriched in salivary glands. Biophysical Chemistry, 189: 25-32.
    40. Wang X, Fang X, Yang P, Jiang X, Jiang F, Zhao D, Li B, Cui F, Wei J, Ma C, Wang Y, He J, Luo Y, Wang Z, Guo X, Guo W, Wang X, Zhang Y, Yang M, Hao S, Chen B, Ma Z, Yu D, Xiong Z, Zhu Y, Fan D, Han L, Wang B, Chen Y, Wang J, Yang L, Zhao W, Feng Y, Chen G, Lian J, Li Q, Huang Z, Yao X, Lv N, Zhang G, Li Y, Wang J, Wang J, Zhu B, Kang L. 2014. The locust genome provides insight into swarm formation and long-distance flight. Nature Communications, 5: 2957.
    41. Mao Y, Tan F, Yan S, Wu G, Qiao C, Zhang W*, Cui F*. 2013. High-throughput genotyping of single-nucleotide polymorphisms in ace-1 gene of mosquitoes using MALDI-TOF mass spectrometry. Insect Science, 20: 167-174.
    42. Wang Y, Yang P, Cui F, Kang L. 2013. Altered immunity in crowded locust reduced fungal (Metarhizium anisopliae) pathogenesis. PLoS Pathogens, 9: e1003102.
    43. Yan S, Nan P, Cui F, Wu Z, Qiao C. (2013). Distribution and dynamics of esterase alleles in Culex pipiens complex in China. Journal of Asia-Pacific Entomology, 16, 43-48.
    44. Yan L, Yang P, Jiang F, Cui N, Ma E, Qiao C, Cui F*. 2012. Transcriptomic and phylogenetic analysis of Culex pipiens quinquefasciatus for three detoxification gene families. BMC genomics, 13: 609.
    45. Zhang H, Meng F, Qiao C, Cui F*. 2012. Identification of resistant carboxylesterase alleles in Culex pipiens complex via PCR-RFLP. Parasites & Vectors, 5: 209.
    46. Wang H#, Ma Z#, Cui F#, Wang X, Guo W, Lin Z, Yang P, Kang L. 2012. Parental phase status affects the cold hardiness of progeny eggs in locusts. Functional Ecology, 26, 379-389.
    47. Cui F, Smith CM, Reese J, Edwards O, Reeck G. 2012. Polymorphisms in salivary-gland transcripts of Russian wheat aphid biotypes 1 and 2. Insect Science, 19, 429-440.
    48. Gong L#, Cui F#, Sheng C, Lin Z, Reeck G, Xu J, Kang L. 2012. Polymorphism and methylation of four genes expressed in salivary glands of Russian wheat aphid (Homoptera: Aphididae). Journal of Economic Entomology, 105: 232-241. (IF: 1.4) (* co-first author)
    49. Lan W, Chen G, Cui F, Tan F, Liu R, Yushupujiang M. 2012. Development of a novel optical biosensor for detection of organophoshorus pesticides based on methyl parathion hydrolase immobilized by metal-chelate affinity. Sensors, 12, 8477-8490.
    50. Yang J, Liu R, Song W, Yang Y, Cui F, Qiao C. 2012. Construction of a genetically engineered microorganism that simultaneously degrades organochlorine and organophosphate pesticides. Applied Biochemistry and Biotechnology, 166: 590-598.
    51. Liu Y, Zhang H, Qiao C, Lu X*, Cui F*. 2011. Correlation between carboxylesterase alleles and insecticide resistance in Culex pipiens complex from China. Parasites & Vectors, 4: 236.
    52. Cui F#, Lin Z#, Wang H, Liu S, Chang H, Reeck G, Qiao C, Raymond M, Kang L. 2011. Two single mutations commonly cause qualitative change of nonspecific carboxylesterases in insects. Insect Biochemistry and Molecular Biology, 41: 1-8. (IF: 4.0)
    53. James C Carolan, Doina Caragea, Karen T Reardon, Navdeep S Mutti, Neal Dittmer, Kirk Pappan, Feng Cui, Marisol Castaneto, Julie Poulain, Carole Dossat, Denis Tagu, John C. Reese, Gerald R. Reeck, Thomas L Wilkinson, and Owain R. Edwards. 2011. Predicted effector molecules in the salivary secretome of the pea aphid (Acyrthosiphon pisum)-A dual transcriptomic-proteomic approach. Journal of Proteome Research, 10: 1505-1518. (IF: 5.4)
    54. Shuaiguo Yan, Feng Cui and Chuan-Ling Qiao. 2009. Structure, function and applications of insect carboxylesterases evolved for insecticide resistance. Protein and Peptide Letters, 16: 1181-1188. (IF: 1.8)
    55. Shuaiguo Yan, Zhonghua Wu, Feng Cui, Qiao Zhao and Chuan-Ling Qiao. 2008. Dynamics of esterase alleles in Culex pipiens complex mosquitoes in Beijing. Journal of Economic Entomology, 101: 1897-1902. (IF: 1.4)
    56. Feng Cui, Hong Qu, Jian Cong, Xiao-Li Liu and Chuan-Ling Qiao. 2007. Do mosquitoes acquire organophosphate resistance by functional changes in carboxylesterases? The FASEB Journal, 21: 3584-3591. (IF: 6.5)
    57. Feng Cui, Mylene Weill, Arnaud Berthomieu, Michel Raymond and Chuan-Ling Qiao. 2007. Characterization of novel esterases in insecticide-resistant mosquitoes. Insect Biochemistry and Molecular Biology, 37: 1131-1137. (IF: 4.0)
    58. Feng Cui, Yi Tan and Chuan-Ling Qiao. 2007. Filariasis vector in China: insecticide resistance and population structure of mosquito Culex pipiens complex. Pest Management Science, 63: 453-458. (IF: 2.3)
    59. Feng Cui, Chuan-Ling Qiao, Ben-Chang Shen, Maite Marquine, Mylene Weill and Michel Raymond. 2007. Genetic differentiation of Culex pipiens in China. Bulletin of Entomological Research, 97: 291-297. (IF: 1.9)
    60. Haoues Alout, Arnaud Berthomieu, Feng Cui, Yi Tan, Claire Berticat, Chuan-Ling Qiao and Mylene Weill. 2007. Different amino-Acid substitutions confer insecticide resistance through acetylcholinesterase 1 insensitivity in Culex vishnui and Culex tritaeniorhynchus (Diptera: Culicidae) from China. Journal of Medical Entomology, 44: 463-469. (IF: 1.9)
    61. Feng Cui, Michel Raymond, Arnaud Berthomieu, Haoues Alout, Mylene Weill and Chuan-Ling Qiao. 2006. Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens. Journal of Medical Entomology, 43: 878-883. (IF: 1.9)
    62. Feng Cui, Michel Raymond and Chuan-Ling Qiao. 2006. Insecticide resistance of vector mosquitoes in China. Pest Management Science, 62: 1013-1022. (IF: 2.3)
    63. Feng Cui, Li-Feng Lin, Chuan-Ling Qiao, Ying Xu, Maite Marquine, Mylene Weill and Michel Raymond. 2006. Insecticide resistance in Chinese populations of the Culex pipiens complex through esterase overproduction. Entomologia Experimentalis et Applicata, 120: 211-220. (IF: 1.4)
    64. K. ZHANG, Z-Q. YE, F. CUI and C-L. QIAO. 2003. Significance of passive migration in evolution of insecticide resistance in the mosquito Culex pipiens (Diptera: Culicidae). Entomologia Sinica, 10: 231-236.