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    CUI Feng
    +86-10-64807218  /  +86-10-64807099
    The State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
    Genomics of vector insect and virus      


    July 2006 – December 2008: Assistant Professor, Institute of Zoology, Chinese Academy of Sciences
    July 2007 –December 2008: Associate Research, Department of Biochemistry, Kansas State University
    January 2009 - December 2016: Associate Professor, Institute of Zoology, Chinese Academy of Sciences
    January 2017- present: Professor, Institute of Zoology, Chinese Academy of Sciences

    September 2003 to July 2006: Ph.D. in Zoology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. Direction: Molecular genetics of insecticide resistance in insects
    September 1999 to July 2002: Shandong Agricultural University, Tai'an, China. Master in Agronomy. Direction: Insect physiology
    September 1995 to July 1999: Shandong Agricultural University, Tai’an, China. Bachelor in Agronomy. Direction: Forestry

    Research Interest:

    My main research direction is exploring the molecular mechanisms of the interactions among vector insects, plant virus and plants. This includes: (1) the interaction mechanisms of persistent-propagative plant viruses with vector insects; (2) the variation of plant viruses during the transmission between vector insect and host plant; (3) the function of saliva proteins in the transmission of persistent-propagative plant viruses and the adaptation of vector insects to their host plants.
    1. The interaction mechanisms of persistent-propagative plant viruses with vector insects. Rice stripe virus (RSV) causes severe damage to rice in temperate and subtropical regions, and is mainly transmitted by Laodelphax striatellus, the small brown plant hopper (SBPH) in a persistent, circulative-propagative manner. Our objective is to identify key genes and proteins of SBPH interacting with viral proteins or regulating viral gene expression, thus influencing RSV incubation in SBPH, transmission and pathogenicity in plants. These proteins or genes are involved in kinds of signal pathways and immune system.
    2. The variation of plant viruses during the transmission between vector insect and host plant. We explore the variation of viral genomes and protein modifications when RSV infects vector insect and host plant. Identify the key genomic characteristics adapting to the two hosts.
    3. The function of saliva proteins in the transmission of persistent-propagative plant viruses and the adaptation of vector insects to their host plants. Salivary gland is the key organ for piercing-sucking insects to recognize and accept host plants. Continuous production of watery saliva occurs as piercing-sucking insects probe sieve elements and ingest phloem sap from individual sieve elements. Insect saliva is predicted to contain proteins that modulate plant defenses and facilitate feeding. In recent years, we explore the function of individual protein-effectors in aphid saliva, trying to answer how the genes or proteins in salivary glands regulate the adaptation of aphids to their host plants. At the same time, we also explore the functions of saliva proteins of SBPH in the transmission of RSV and the adaptation of SBPH to host plants.

    Public Services:

    Awards and Honors:

    Research Grants:

    Selected Publication:
    1. Wei Wang#, Wan Zhao#, Jing Li#, Lan Luo, Le Kang*, Feng Cui*. 2017. The c-Jun N-terminal kinase pathway of a vector insect is activated by virus capsid protein and promotes viral replication. eLife. 6: e26591.
    2. Liuping Zhang#, Hong Lu#, Kun Guo#, Shumin Yao, Feng Cui*. 2017. Insecticide resistance status and detoxification enzymes of wheat aphids Sitobion avenae and Rhopalosiphum padi. Science China Life Sciences. 60, doi: 10.1007/s11427-017-9105-x.
    3. Kun Guo, Pengcheng Yang, Jun Chen, Hong Lu, Feng Cui*. 2017. Transcriptomic responses of three aphid species to chemical insecticide stress. Science China Life Sciences. 60, doi: 10.1007/s11427-017-9104-5.
    4. Na Cui#, Pengcheng Yang#, Kun Guo, Le Kang*, Feng Cui*. 2017. Large-scale gene expression reveals different adaptations of Hyalopterus persikonus to winter and summer host plants. Insect Science, 24, 431-442.
    5. Wan Zhao, Pengcheng Yang, Le Kang*, Feng Cui*. 2016. Different Pathogenicities of Rice Stripe Virus from the Insect Vector and from Viruliferous Plants. New Phytologist. 210: 196-207.
    6. Wan Zhao, Lixia Lu, Pengcheng Yang, Na Cui, Le Kang*, Feng Cui*. 2016. Organ-specific transcriptome response of the small brown planthopper toward rice stripe virus. Insect Biochemistry and Molecular Biology, 70: 60-72.
    7. Feng Cui#, Wan Zhao#, Lan Luo, Le Kang. 2016. Rice responses and resistance to planthopper-borned viruses at transcriptomic and proteomic levels. Current Issues in Molecular Biology. 19: 43-52.
    8. Hong Lu, Pengcheng Yang, Yongyu Xu, Lan Luo, Junjie Zhu, Na Cui, Le Kang*, Feng Cui*. 2016. Performances of survival, feeding behavior, and gene expression in aphids reveal their different fitness to host alteration. Scientific Reports. 6:19344.
    9. Zhang F, Li Q, Chen X, Huo Y, Guo H, Song Z, Cui F, Zhang L, Fang R. 2016. Roles of the Laodelphax striatellus Down syndrome cell adhesion molecule in Rice stripe virus infection of its insect vector. Insect Molecular Biology. 25: 413-421.
    10. Hong Lu, Yongyu Xu, Feng Cui*. 2016. Phylogenetic analysis of the ATP-binding cassette transporter family in three mosquito species. Pesticide Biochemistry and Physiology. 132: 118-124.
    11. Yuming Pan, Junjie Zhu, Lan Luo, Le Kang*, Feng Cui*. 2015. High expression of a unique aphid protein in the salivary glands of Acyrthosiphon pisum. Physiological and Molecular Plant Pathology. Accepted.
    12. Wei Wang, Huaien Dai, Yi Zhang, Raman Chandrasekar, Lan Luo, Yasuaki Hiromasa, Changzhong Sheng, Gongxin Peng, Shaoliang Chen, John M. Tomich, John Reese, Owain Edwards, Le Kang, Gerald Reeck*, Feng Cui*. 2015. Armet is an effector protein mediating aphid-plant interactions. FASEB Journal. 29: 2032-2045.
    13. Wei Wang, Lan Luo, Hong Lu, Shaoliang Chen, Le Kang, Feng Cui*. 2015. Angiotensin-converting enzymes modulate aphid–plant interactions. Scientific Reports, 5: 8885.
    14. Feng Cui#, Mei-Xia Li#, Hai-Jing Chang, Yun Mao, Han-Ying Zhang, Li-Xia Lu, Shuai-Guo Yan, Ming-Lin Lang, Li Liu, Chuan-Ling Qiao. 2015. Carboxylesterase-mediated insecticide resistance: quantitative increase induces broader metabolic resistance than qualitative change. Pesticide Biochemistry and Physiology, 121: 88-96.
    15. Wei Wang, Silu Liu, Yangyang Liu, Chuanling Qiao, Shaoliang Chen*, Feng Cui*. 2015. Over-transcription of genes in a parathion-resistant strain of mosquito Culex pipiens quinquefasciatus. Insect Science, 22: 150-156.
    16. Feng Cui#, Hongsheng Wang#, Hanying Zhang, Le Kang. 2014. Anoxic stress and rapid cold hardening enhance cold tolerance of the migratory locust. Cryobiology, 69: 243-248.
    17. Kun Guo, Wei Wang, Lan Luo, Jun Chen, Ya Guo, Feng Cui*. 2014. Characterization of an aphid-specific, cysteine-rich protein enriched in salivary glands. Biophysical Chemistry, 189: 25-32.
    18. Xianhui Wang, Xiaodong Fang, Pengcheng Yang, Xuanting Jiang, Feng Jiang, Dejian Zhao, Bolei Li, Feng Cui et al. 2014. The locust genome provides insight into swarm formation and long-distance flight. Nature Communications, 5: 2957.
    19. Yun Mao, Feng Tan, Shuai-Guo Yan, Guo-Xing Wu, Chuan-Ling Qiao, Wen-Xue Zhang*, Feng Cui*. 2013. High-throughput genotyping of single-nucleotide polymorphisms in ace-1 gene of mosquitoes using MALDI-TOF mass spectrometry. Insect Science, 20: 167-174.
    20. Yundan Wang, Pengcheng Yang, Feng Cui, Le Kang. 2013. Altered immunity in crowded locust reduced fungal (Metarhizium anisopliae) pathogenesis. PLoS Pathogens, 9: e1003102.
    21. Yan, S., Nan, P., Cui, F., Wu, Z., & Qiao, C. (2013). Distribution and dynamics of esterase alleles in Culex pipiens complex in China. Journal of Asia-Pacific Entomology, 16, 43-48.
    22. Liangzhen Yan, Pengcheng Yang, Feng Jiang, Na Cui, Enbo Ma, Chuanling Qiao, Feng Cui*. 2012. Transcriptomic and phylogenetic analysis of Culex pipiens quinquefasciatus for three detoxification gene families. BMC genomics, 13: 609.
    23. Hanying Zhang, Fengxia Meng, Chuanling Qiao, Feng Cui*. 2012. Identification of resistant carboxylesterase alleles in Culex pipiens complex via PCR-RFLP. Parasites & Vectors, 5: 209.
    24. Hongsheng Wang#, Zongyuan Ma#, Feng Cui#, Xianhui Wang, Wei Guo, Zhe Lin, Pengcheng Yang, and Le Kang. 2012. Parental phase status affects the cold hardiness of progeny eggs in locusts. Functional Ecology, 26, 379-389.
    25. Feng Cui, C. Michael Smith, John Reese, Owain Edwards, and Gerald Reeck. 2012. Polymorphisms in salivary-gland transcripts of Russian wheat aphid biotypes 1 and 2. Insect Science, 19, 429-440.
    26. Lu Gong#, Feng Cui#, Changzhong Sheng, Zhe Lin, Gerald Reeck, Jichen Xu, Le Kang. 2012. Polymorphism and methylation of four genes expressed in salivary glands of Russian wheat aphid (Homoptera: Aphididae). Journal of Economic Entomology, 105: 232-241.
    27. Wensheng Lan, Guoping Chen, Feng Cui, Feng Tan, Ran Liu, Maolidan Yushupujiang. 2012. Development of a novel optical biosensor for detection of organophoshorus pesticides based on methyl parathion hydrolase immobilized by metal-chelate affinity. Sensors, 12, 8477-8490.
    28. Jijian Yang, Ruihua Liu, Wenli Song, Yao Yang, Feng Cui, Chuanling Qiao. 2012. Construction of a genetically engineered microorganism that simultaneously degrades organochlorine and organophosphate pesticides. Applied Biochemistry and Biotechnology, 166: 590-598.
    29. Yangyang Liu, Hanying Zhang, Chuanling Qiao, Xiping Lu*, Feng Cui*. 2011. Correlation between carboxylesterase alleles and insecticide resistance in Culex pipiens complex from China. Parasites & Vectors, 4: 236.
    30. Feng Cui#, Zhe Lin#, Hongsheng Wang, Silu Liu, Haijing Chang, Gerald Reeck, Chuanling Qiao, Michel Raymond, and Le Kang. 2011. Two single mutations commonly cause qualitative change of nonspecific carboxylesterases in insects. Insect Biochemistry and Molecular Biology, 41: 1-8.
    31. James C Carolan, Doina Caragea, Karen T Reardon, Navdeep S Mutti, Neal Dittmer, Kirk Pappan, Feng Cui, Marisol Castaneto, Julie Poulain, Carole Dossat, Denis Tagu, John C. Reese, Gerald R. Reeck, Thomas L Wilkinson, and Owain R. Edwards. 2011. Predicted effector molecules in the salivary secretome of the pea aphid (Acyrthosiphon pisum)-A dual transcriptomic-proteomic approach. Journal of Proteome Research, 10: 1505-1518.
    32. Feng Cui, Hong Qu, Jian Cong, Xiao-Li Liu and Chuan-Ling Qiao. 2007. Do mosquitoes acquire organophosphate resistance by functional changes in carboxylesterases? The FASEB Journal, 21: 3584-3591.
    33. Feng Cui, Mylene Weill, Arnaud Berthomieu, Michel Raymond and Chuan-Ling Qiao. 2007. Characterization of novel esterases in insecticide-resistant mosquitoes. Insect Biochemistry and Molecular Biology, 37: 1131-1137.
    34. Feng Cui, Yi Tan and Chuan-Ling Qiao. 2007. Filariasis vector in China: insecticide resistance and population structure of mosquito Culex pipiens complex. Pest Management Science, 63: 453-458.
    35. Feng Cui, Michel Raymond, Arnaud Berthomieu, Haoues Alout, Mylene Weill and Chuan-Ling Qiao. 2006. Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens. Journal of Medical Entomology, 43: 878-883.
    36. Feng Cui, Michel Raymond and Chuan-Ling Qiao. 2006. Insecticide resistance of vector mosquitoes in China. Pest Management Science, 62: 1013-1022.
    37. Feng Cui, Li-Feng Lin, Chuan-Ling Qiao, Ying Xu, Maite Marquine, Mylene Weill and Michel Raymond. 2006. Insecticide resistance in Chinese populations of the Culex pipiens complex through esterase overproduction. Entomologia Experimentalis et Applicata, 120: 211-220.
    38. Feng Cui, Chuan-Ling Qiao, Ben-Chang Shen, Maite Marquine, Mylene Weill and Michel Raymond. 2007. Genetic differentiation of Culex pipiens in China. Bulletin of Entomological Research, 97: 291-297.
    39. Haoues Alout, Arnaud Berthomieu, Feng Cui, Yi Tan, Claire Berticat, Chuan-Ling Qiao and Mylene Weill. 2007. Different amino-Acid substitutions confer insecticide resistance through acetylcholinesterase 1 insensitivity in Culex vishnui and Culex tritaeniorhynchus (Diptera: Culicidae) from China. Journal of Medical Entomology, 44: 463-469.
    40. Shuaiguo Yan, Zhonghua Wu, Feng Cui, Qiao Zhao and Chuan-Ling Qiao. 2008. Dynamics of esterase alleles in Culex pipiens complex mosquitoesin Beijing. Journal of Economic Entomology, 101: 1897-1902.
    41. Shuaiguo Yan, Feng Cui and Chuan-Ling Qiao. 2009. Structure, function and applications of insect carboxylesterases evolved for insecticide resistance. Protein and Peptide Letters, 16: 1181-1188.
    42. K. ZHANG, Z-Q. YE, F. CUI and C-L. QIAO. 2003. Significance of passive migration in evolution of insecticide resistance in the mosquito Culex pipiens (Diptera: Culicidae). Entomologia Sinica, 10: 231-236.