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    ZOU Zhen
    Genomics/Biochemistry and Molecular Biology/Information biology
    +86-10-64807191  /  +86-10-64807099
    The State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
    Group of Insect immunity and devolopment      

    Dr. Zhen Zou received his Ph.D. degree in Department of Entomology and Plant Pathology, Oklahoma State University (2005) and then move to work in Oklahoma State University and University of California-Riverside as a postdoctoral fellow. He worked at University of California-Riverside as an assistant researcher from 2010 to 2012. He came back to China in 2012 as a scholar of “One Thousand Youth Talents Scheme”. Now he is the group leader of Insect Immunity and Development Group of Institute of zoology, CAS.
    Dr Zou had studied in insect development and immunity for more than twenty years. Using a series of approaches of genomics, molecular biology, and cellular biology, he revealed the mechanism of insect immune pathways, the role of melanization in the immune response against pathogens and parasites, and hormone regulated mosquito reproduction.
    Research Interest:
    His current research interest focuses on understanding (1) the molecular basis of events in the mosquito reproduction cycle linked to a blood meal and pathogen transmission, (2) the role of antifungal and antiviral immune response in mosquitoes, (3) the biochemical and molecular adaptation of parasitoid wasp and other biopesticide to it hosts. His funds are from NSFC, MOST, and CAS.
    Public Services:

    Awards and Honors:

    Research Grants:

    Selected Publication:
    1. Yuan C, Xing L, Wang M, Wang X, Yin M, Wang Q, Hu Z#, and Zou Z# (2017). Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera. PLoS Pathog13, e1006645.
    2. Wang X, Hou Y, Saha TT, Pei G, Raikhel AS#, Zou Z#. Hormone and receptor interplay in the regulation of mosquito lipid metabolism. Proc Natl Acad Sci U S A. 2017; 114(13):E2709-E2718. doi: 10.1073/pnas.1619326114.
    3. Wang Y, Jiang H, Cheng Y, An C, Chu Y, Raikhel AS, Zou Z#. Activation of Aedes aegypti prophenoloxidase-3 and its role in the immune response against entomopathogenic fungi. Insect Mol Biol. 2017 May 27. doi: 10.1111/imb.12318.
    4. Xing L, Yuan C, Wang M, Lin Z, Shen B, Hu Z, Zou Z#. Dynamics of the interaction between cotton bollworm Helicoverpa armigera and nucleopolyhedrovirus as revealed by integrated transcriptomic and proteomic analyses. Mol Cell Proteomics.2017; pii: mcp.M116.062547. doi: 10.1074/mcp.M116.062547.
    5. Zhao LL, Zhang X, Wei Y, Zhou J, Zhang W, Qin P, Chinta S, Kong X, Liu Y, Yu H, Hu S, Zou Z#, Butcher RA#, Sun JH#. Ascarosides coordinate the dispersal of a plant-parasitic nematode with the metamorphosis of its vector beetle. Nat Commun. 2016; 7:12341, doi: 10.1038/ncomms. 12341.
    6. Zhao B, Hou Y, Wang J, Kokoza VA, Saha TT, Wang XL, Lin L, Zou Z#, Raikhel AS#. Determination of juvenile hormone titers by means of LC-MS/MS/MS and a juvenile hormone-responsiveGal4/UAS system in Aedes aegypti mosquitoes. Insect Biochem Mol Biol. 2016; 77:69-77, doi: 10.1016/j.ibmb. 2016.08.003.
    7. Roy, S., Saha, T. T., Johnson, L., Zhao, B., Ha, J., White, K. P., Girke, T., Zou, Z#. and Raikhel, A. S#. Regulation of gene expression patterns in mosquito reproduction. PLoS Genet. 2015; 11(8), e1005450. doi: 10.1371/journal.pgen. 1005450. 
    8. Hou, Y., Wang X.L., Saha, T.T., Roy, S., Zhao, B., Raikhel, A.S.#, Zou Z#. Temporal Coordination of Carbohydrate Metabolism during Mosquito Reproduction. PLoS Genet. 2015; 11(7): e1005309. doi: 10.1371/journal.pgen. 1005309.
    9. Meng, Q., Yu, H.Y.,  Zhang, H., Zhu, W., Wang, M.L., Zhang, J.H., Zhou, G.L., Li, X., Qin, Q.L.#, Hu, S.N.#, Zou, Z#.  Transcriptomic insight into the immune defenses in the ghost moth, Hepialus xiaojinensis, during an Ophiocordyceps sinensis fungal infection. Insect Biochem Mol Biol. 2015; 64:1-15. doi: 10.1016/j.ibmb. 2015.06.014.
    10. Wang, Y.H., Hu, Y., Xing, L.S., Jiang, H., Hu, S.N., Raikhel, A.S. #, Zou, Z#. A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. PLoS Pathog. 2015; 11(6):e1004931. doi: 10.1371/journal.ppat. 1004931.
    11. Xiong, G.H., Xing, L.S., Lin, Z., Saha, T.T., Wang, C., Jiang, H., Zou, Z#. High throughput profiling of the cotton bollworm Helicoverpa armigera immunotranscriptome during the fungal and bacterial infections. BMC Genomics. 2015; 16(1):321. doi: 10.1186/s12864-015-1509-1.
    12. Zou, Z.*, Saha, T.T.*, Roy, S.*, Shin, S.W., Backman, T.W., Girke, T., White, K.P., and Raikhel, A.S. Juvenile hormone and its receptor, methoprene-tolerant, control the dynamics of mosquito gene expression. Proc Natl Acad Sci U S A. 2013; 110(24): E2173-81. doi: 10.1073/pnas.1305293110.
    13. Zou, Z.*, Souza-Neto, J.A.*, Xi, Z., Shin, S.W., Alvarez, K.S., Kokoza, K., Dimopoulos, G., Raikhel, A.S. Transcriptome Analysis of Aedes aegypti Transgenic Mosquitoes with Altered Immunity. PLoS Pathog. 2011; 7(11):e1002394. doi: 10.1371/journal.ppat.1002394.
    14. Zou, Z.*, Shin, S.W.*, Alvarez, K.S., Kokoza, K., Raikhel, A.S. Distinct melanization pathways in the mosquito Aedes aegypti. Immunity. 2010; 32(1):41-53. doi: 10.1016/j.immuni.2009.11.011.
    15. Zou, Z.*, Shin, S.W.*, Alvarez, K.S., Bian, G., Kokoza, K., Raikhel, A.S. Mosquito RUNX4 in the immune regulation of PPO gene expression and its effect on avian malaria parasite infection. Proc Natl Acad Sci U S A. 2008; 105(47):18454-9. doi: 10.1073/pnas.0804658105.
    16. Zou, Z., Evans, J., Lu, Z., Zhao, P., Williams, M., Sumathipala, N., Hetru, C., Hultmark D., Jiang H. (2007) Comparative genomic analysis of the Tribolium immune system. Genome Biol.2007; 8(8):R177. doi:  10.1186/gb-2007-8-8-r177.
    17. Zou, Z., Jiang, H. Manduca sexta serpin-6 regulates immune serine proteinases PAP-3 and HP8. cDNA cloning, protein expression, inhibition kinetics, and function elucidation. J Biol Chem. 2005; 280(14), 14341-8. doi: 10.1074/jbc.M500570200.