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    Name:
    		 ZHANG Xiaoming
    Subject:
    		 Biochemistry and Molecular Biology/Genomics
    Tel/Fax:
    		 +86-10-64806891  / 
    E-mail:
    		 zhangxm@ioz.ac.cn
    Address:
    		 The State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
    More:
    		 Group of Epigenetics and Resistance      

    Resume：

    Zhang Xiaoming, doctor, professor, doctoral supervisor; Leader of “Epigenetics and Resistance” research group, Institute of zoology, Chinese Academy of Sciences. Received "excellent youth fund" project of National Natural Science Foundation of China in 2016.

    Received the bachelor's degree from Nankai University in 2001, and the doctorate degree from Peking University in 2007. Performed post-doctoral research at the University of California, riverside, from 2008-2014.

    Focuses on the role of non-coding RNA in crop antiviral defense and the function of organelle interaction in organism resistance response; Analyzes the interaction among pathogen, host and insect vector at the aspects of molecular biology, cell biology and omics; Explores the dynamic balance of membraneless organelle that contributes to RNA silencing and crop-virus interaction, and the role of membraneless organelles in the regulation of virus replication and host anti-viral resistance; Investigates the regulatory function of lncRNA in crop disease resistance, and explores the regulatory network of non-coding RNA in crops. Explores the roles of non-coding RNAs in mammalian cell immunity and the underlying mechanisms.

    Research results were published in Cell Host & Microbe, Molecular Cell, Science Advances, Genome Biology, Nature Communications, Frontiers in Immunology and et al.
    Research Interest：
    Aim to analyze the resistance mechanism of animals/plants to pathogens/insect vectors, main research includes: 1) the function of non-coding RNA in organism immunity; 2) the significance of organelle interaction on organism resistance.
    Public Services：

    Awards and Honors：

    Research Grants：

    Selected Publication：
    1. Li Q#, Liu Y#, Zhang X*. Biomolecular condensates in plant RNA silencing: insights into formation, function, and stress responses. Plant Cell. 2023; Online ahead of print.
    2. Huang J#, Zhou W#, Zhang X*, Li Y*. A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. PLoS Pathogens. 2023; e1011340.
    3. Liu N#, Xu Y#, Li Q, Cao Y, Yang D, Liu S, Wang X, Mi Y, Liu Y, Ding C, Liu Y, Li Y, Yuan YW, Gao G, Chen J*, Qian W*, Zhang X*. A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth. Cell Host & Microbe. 2022;30(8):1124-38 e8.
    4. Liu Y#, Rao J#, Mi Y#, Chen L, Feng L, Li Q, Geng J, Yang X, Zhan X, Ren L*, Chen J*, Zhang X*. SARS-CoV-2 RNAs are processed into 22-nt vsRNAs in Vero cells. Front Immunol. 2022;13:1008084.
    5. Du J, Liu Y, Lu L, Shi J, Xu L, Li Q, Cheng X, Chen J*, Zhang X*. Accumulation of DNA damage alters microRNA gene transcription in Arabidopsis thaliana. BMC Plant Biol. 2022;22(1):576.
    6. Cheng Y, Lu T, Guo J, Lin Z, Jin Q, Zhang X*, Zou Z*. Helicoverpa armigera miR-2055 regulates lipid metabolism via fatty acid synthase expression. Open Biol. 2022;12(3):210307.
    7. Liu Q#, Liu Y#, Li Q#, Qian W, Zhang X*. Determining the phase separation characteristics of plant proteins. Curr Protoc. 2021;1(9):e237.
    8. Li Q#, Liu N#, Liu Q#, Zheng X, Lu L, Gao W, Liu Y, Liu Y, Zhang S, Wang Q, Pan J, Chen C, Mi Y, Yang M, Cheng X, Ren G, Yuan YW, Zhang X*. DEAD-box helicases modulate dicing body formation in Arabidopsis. Science Advances. 2021;7(18).
    9. Gao W#, Liu Y#, Huang J#, Chen Y, Chen C, Lu L, Zhao H, Men S*, Zhang X*. MES7 modulates seed germination via regulating salicylic acid content in Arabidopsis. Plants (Basel). 2021;10(5).
    10. Zhang B#, Zhao L#, Ning J, Wickham JD, Tian H, Zhang X, Yang M, Wang X, Sun J*. miR-31-5p regulates cold acclimation of the wood-boring beetle Monochamus alternatus via ascaroside signaling. BMC Biol. 2020;18(1):184.
    11. Liu Y#, Gao W#, Wu S#, Lu L, Chen Y, Guo J, Men S, Zhang X*. AtXRN4 affects the turnover of chosen miRNA*s in Arabidopsis. Plants (Basel). 2020;9(3).
    12. 杨美玲, 李琦, 陈佳琦, 张晓明*. RNA 沉默转基因技术在植物抗病虫害研究中的作用. 植物保护, 46 (4), 1-6.
    13. Zhao W#, Xu Z#, Zhang X, Yang M, Kang L*, Liu R*, Cui F*. Genomic variations in the 3'-termini of Rice stripe virus in the rotation between vector insect and host plant. New Phytol. 2018;219(3):1085-96.
    14. Yang M#, Xu Z#, Zhao W#, Liu Q, Li Q, Lu L, Liu R*, Zhang X*, Cui F*. Rice stripe virus-derived siRNAs play different regulatory roles in rice and in the insect vector Laodelphax striatellus. BMC Plant Biol. 2018;18(1):219.
    15. Huang J#, Yang M#, Zhang X*. The function of small RNAs in plant biotic stress response. J Integr Plant Biol. 2016;58(4):312-27.
    16. Huang J#, Yang M#, Lu L*, Zhang X*. Diverse functions of small RNAs in different plant-pathogen communications. Front Microbiol. 2016;7:1552.
    17. Zhang X, Niu D, Carbonell A, Wang A, Lee A, Tun V, Wang Z, Carrington JC, Chang CE, Jin H*. ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. Nat Commun. 2014;5:5468.
    18. Zhang X, Lii Y, Wu Z, Polishko A, Zhang H, Chinnusamy V, Lonardi S, Zhu JK*, Liu R*, Jin H*. Mechanisms of small RNA generation from cis-NATs in response to environmental and developmental cues. Mol Plant. 2013;6(3):704-15.
    19. Zhang X#, Xia J#, Lii YE, Barrera-Figueroa BE, Zhou X, Gao S, Lu L, Niu D, Chen Z, Leung C, Wong T, Zhang H, Guo J, Li Y, Liu R, Liang W, Zhu JK, Zhang W*, Jin H*. Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function. Genome Biol. 2012;13(3):R20.
    20. Zhang X#, Zhao H#, Gao S, Wang WC, Katiyar-Agarwal S, Huang HD, Raikhel N, Jin H*. Arabidopsis Argonaute 2 regulates innate immunity via miRNA393(*)-mediated silencing of a Golgi-localized SNARE gene, MEMB12. Mol Cell. 2011;42(3):356-66.
    21. Zhang W*, Gao S, Zhou X, Chellappan P, Chen Z, Zhou X, Zhang X, Fromuth N, Coutino G, Coffey M, Jin H*. Bacteria-responsive microRNAs regulate plant innate immunity by modulating plant hormone networks. Plant Mol Biol. 2011;75(1-2):93-105.
    22. Zhang W#, Gao S#, Zhou X, Xia J, Chellappan P, Zhou X, Zhang X, Jin H*. Multiple distinct small RNAs originate from the same microRNA precursors. Genome Biol. 2010;11(8):R81.
    23. Chellappan P, Xia J, Zhou X, Gao S, Zhang X, Coutino G, Vazquez F, Zhang W*, Jin H*. siRNAs from miRNA sites mediate DNA methylation of target genes. Nucleic Acids Res. 2010;38(20):6883-94.
    24. Zhou P, Ren B, Zhang X, Wang Y, Wei CH, Li Y*. Stable expression of rice dwarf virus Pns10 suppresses the post-transcriptional gene silencing in transgenic Nicotiana benthamiana plants. Acta Virol. 2010;54(2):99-104.
    25. Tsuchisaka A#, Yu G#, Jin H, Alonso JM, Ecker JR, Zhang X, Gao S, Theologis A*. A combinatorial interplay among the 1-aminocyclopropane-1-carboxylate isoforms regulates ethylene biosynthesis in Arabidopsis thaliana. Genetics. 2009;183(3):979-1003.
    26. Padmanabhan C#, Zhang X#, Jin H*. Host small RNAs are big contributors to plant innate immunity. Curr Opin Plant Biol. 2009;12(4):465-72.
    27. Zhang X, Du P, Lu L, Xiao Q, Wang W, Cao X, Ren B, Wei C, Li Y*. Contrasting effects of HC-Pro and 2b viral suppressors from Sugarcane mosaic virus and Tomato aspermy cucumovirus on the accumulation of siRNAs. Virology. 2008;374(2):351-60.
    28. Cao X, Zhou P, Zhang X, Zhu S, Zhong X, Xiao Q, Ding B, Li Y*. Identification of an RNA silencing suppressor from a plant double-stranded RNA virus. J Virol. 2005;79(20):13018-27