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Developmental Biology
+86-010-64807299  /  +86-10-64807306
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences (CAS).
Institute for Stem Cell and Regenerative Medicine, CAS, Yard A 3, Datun Road, Chaoyang District, Beijing 100101, P. R. China
Group of Reproductive Engineering      

ZHOU Qi, Ph.D., is a professor in life sciences, and is now the Vice President and Member of the Presidium of the Chinese Academy of Sciences (CAS). He is also the president of Beijing Institute of Stem Cell and Regenerative Medicine. Prof. ZHOU is CAS Member and Fellow of The World Academy of Sciences for the advancement of science in developing countries (TWAS). Prof. ZHOU's research interests cover stem cell, reproductive and developmental biology, and he is also dedicated to promoting the application of stem cells to clinical use. He has been serving as the chief scientist of several national and CAS research projects in areas of reproductive and developmental biology, and stem cells. He has made innovative and significant achievements in animal cloning, improving cloning efficiency, revealing regulatory mechanisms of stem cell pluripotency and cell fate decision, generation of new types of stem cells, mammalian same-sex reproduction, obtaining gametes in vitro, establishing stem cell resource center, and clinical application of stem cells. Prof. ZHOU has been awarded many prizes and honors, including the National Natural Science Award (second-class) of China, the Award for Outstanding Achievements in Science and Technology of the Chinese Academy of Sciences, the Award for Outstanding Youth in Basic Sciences of Zhou Guang Zhao Foundation, the Prize for Scientific and Technological Progress of Ho Leung Ho Lee Foundation, the 3rd genOway Prize for Transgenic Technologies, and TWAS Prize in Biology.

Research Interests:

Basic and application research of stem cell, reproductive, and developmental biology.

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Wang LB#, Li ZK#, Wang LY#, Xu K#, Ji TT#, Mao YH, Ma SN, Liu T, Tu CF, Zhao Q, Fan XN, Liu C, Wang LY, Shu YJ, Yang N, Zhou Q*, Li W*. A sustainable mouse karyotype created by programmed chromosome fusion. (2022) Science 377(6609):967-975. doi: 10.1126/science.abm1964.
  2. Wang LY#, Li ZK#, Wang LB#, Liu C#, Sun XH, Feng GH, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. (2020) Cell Stem Cell 27(2):315-325.e5. doi: 10.1016/j.stem.2020.05.014.
  3. Peng YJ*, Huang X, Zhou Q*. Ethical and Policy Considerations for Human Embryo and Stem Cell Research in China. (2020) Cell Stem Cell 27(4):511-514. doi: 10.1016/j.stem.2020.09.010.
  4. Fu R#, Yu D#, Ren J#, Li C#, Wang J, Feng G, Wang X, Wan H, Li T, Wang L, Zhang Y, Hai T*, Li W*, Zhou Q*. Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs. (2020) Protein Cell. 11(2):97-107. doi: 10.1007/s13238-019-00676-8.
  5. Cui T#, Jiang L#, Li T#, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W*, Zhou Q*. Derivation of Mouse Haploid Trophoblast Stem Cells. (2019) Cell Rep. 26(2):407-414.e5. doi: 10.1016/j.celrep.2018.12.067.
  6. Li Y#, Wang L#, Zhang L#, He Z#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. (2019) J Cell Biol. 218(5):1553-1563. doi: 10.1083/jcb.201808088.
  7. Wang L#, Wu W#, Gu Q#, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q*, Yin Z*, Hao J*. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. (2019) Protein Cell. 10(6):455-460. doi: 10.1007/s13238-018-0606-8.
  8. Wang J#, Wang L#, Feng G#, Wang Y#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. (2018) Cell 175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.
  9. Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. (2018) Cell Stem Cell 23(5):665-676.e4. doi: 10.1016/j.stem.2018.09.004.
  10. Li TD#, Feng GH#, Li YF#, Wang M#, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q*. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. (2017) Proc Natl Acad Sci U S A. 114(45):11974-11979. doi: 10.1073/pnas.1708710114.
  11. He ZQ#, Xia BL#, Wang YK#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q*. Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening. (2017) Cell Rep. 20(9):2227-2237. doi: 10.1016/j.celrep.2017.07.081.
  12. Gu Q#, Wang J#, Wang L#, Liu ZX, Zhu WW, Tan YQ, Han WF, Wu J, Feng CJ, Fang JH, Liu L, Wang L, Li W, Zhao XY, Hu BY, Hao J*, Zhou Q*. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. (2017) Stem Cell Reports 9(1):366-380. doi: 10.1016/j.stemcr.2017.04.017.
  13. Li X#, Cui XL#, Wang JQ#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and application of mouse-rat allodiploid embryonic stem cells. (2016) Cell 164(1-2):279-292. doi: 10.1016/j.cell.2015.11.035.
  14. Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W*, Zhou Q*, Hu B*. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. (2016) Cell Res. 26(1):135-138. doi: 10.1038/cr.2015.151.
  15. Zhou Q#, Wang M#, Yuan Y#, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY*, Sha J*, Zhou Q* Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. (2016) Cell Stem Cell 18(3):330-340. doi: 10.1016/j.stem.2016.01.017.
  16. Chen Q#*, Yan M#, Cao Z#, Li X#, Zhang Y#, Shi J#, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. (2016) Science 351(6271):397-400. doi: 10.1126/science.aad7977.
  17. Wan H#, Feng C#, Teng F#, Yang S#, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W*, Zhao X*, Zhou Q*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. (2015) Cell Res. 25(2):258-261. doi: 10.1038/cr.2014.158.
  18. Chen Y#, Niu Y#, Li Y#, Ai Z, Kang Y, Shi H, Xiang Z, Yang Z, Tan T, Si W, Li W, Xia X, Zhou Q*, Ji W*, Li T*. Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells. (2015) Cell Stem Cell 17(1):116-124. doi: 10.1016/j.stem.2015.06.004.
  19. Chen T#, Hao YJ#, Zhang Y#, Li MM#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG*, Zhou Q*. m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. (2015) Cell Stem Cell 16(3):289-301. doi: 10.1016/j.stem.2015.01.016.
  20. Li X#, Wang JQ#, Wang LY#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q*. Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. (2015) J Mol Cell Biol. 7(5):486-488. doi: 10.1093/jmcb/mjv055.
  21. Shuai L#, Wang Y#, Dong M#, Wang X#, Sang L, Wang M, Wan H, Luo G, Gu T, Yuan Y, Feng C, Teng F, Li W, Liu X, Li T, Wang L, Wang XJ, Zhao XY, Zhou Q*. Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro. (2015) J Mol Cell Biol. 7(4):326-337. doi: 10.1093/jmcb/mjv044.
  22. Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W,Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q. CRISPR germline engineering—the community speaks. (2015) Nat. Biotechnol. 33(5):478-486. doi: 10.1038/nbt.3227.
  23. Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi Y-M, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha H-Y, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang S-M, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo S-K, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh S-K, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN*, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan B-Z, Zeng F, Zhou Q. Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI). (2015) Regen. Med. 10(2 Suppl):1-44. doi: 10.2217/rme.14.93.
  24. Wang J#, Hao J#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z*, Zhou Q*. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. (2015) Stem Cell Res Ther. 6(1):223. doi: 10.1186/s13287-015-0206-y.
  25. Li W#, Li X#, Li T#, Jiang MG#, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q*. Genetic modification and screening in rat using haploid embryonic stem cells. (2014) Cell Stem Cell 14(3):404-414. doi: 10.1016/j.stem.2013.11.016.
  26. Hai T#, Teng F#, Guo R, Li W, Zhou Q*. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. (2014) Cell Res. 24(3):372-375. doi: 10.1038/cr.2014.11.
  27. Zhou Q*. Balancing the welfare: the use of non-human primates in research. (2014) Trends Genet. 30(11):476-478. doi: 10.1016/j.tig.2014.09.005.
  28. Gu Q#, Hao J#, Hai T#, Wang J#, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. (2014) Protein Cell. 5(5):338-342. doi: 10.1007/s13238-014-0043-2.
  29. Li W#, Teng F#, Li T, Zhou Q*. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. (2013) Nat. Biotechnol. 31(8):684-686. doi: 10.1038/nbt.2652.
  30. Wan H#, He Z#, Dong M, Gu T, Luo GZ, Teng F, Xia B, Li W, Feng C, Li X, Li T, Shuai L, Fu R, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Parthenogenetic haploid embryonic stem cells produce fertile mice. (2013) Cell Res. 23(11):1330-1333. doi: 10.1038/cr.2013.126.
  31. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ*, Zhou Q*. MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. (2013) J Biol. Chem. 288(33):23659-23665. doi: 10.1074/jbc.M113.475608.
  32. Li W#, Shuai L#, Wan H#, Dong M#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. (2012) Nature 490(7420):407-411. doi: 10.1038/nature11435.
  33. Sheng C#, Zheng Q#, Wu J#, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z*, Zhou Q*. Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. (2012) Cell Res. 22(1):208-218. doi: 10.1038/cr.2011.175.
  34. Sheng C#, Zheng Q#, Wu J#, Xu Z, Sang L, Wang L, Guo C, Zhu W, Tong M, Liu L, Li W, Liu ZH, Zhao XY, Wang L, Chen Z*, Zhou Q*. Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors. (2012) Cell Res. 22(4):769-772. doi: 10.1038/cr.2012.32.
  35. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. (2012) Protein Cell. 3(1):71-79. doi: 10.1007/s13238-012-2007-8.
  36. Tong M#, Lv Z#, Liu L#, Zhu H#, Zheng QY#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng F, Wang L, Wang XJ, Sha JH*, Zhou Q*. Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. (2011) Cell Res. 21(11):1634-1637. doi: 10.1038/cr.2011.143.
  37. Li W#, Zhao XY#, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L*, Zhou Q*. iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. (2011) Cell Res. 21(3):550-553. doi: 10.1038/cr.2011.25.
  38. Riaz A#, Zhao X#, Dai X#, Li W, Liu L, Wan H, Yu Y, Wang L, Zhou Q*. Mouse cloning and somatic cell reprogramming using electrofused blastomeres. (2011) Cell Res. 21(5):770-778. doi: 10.1038/cr.2010.180.
  39. Niu Y#, Yu Y#, Bernat A#, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P*, Zhang K*, Zhou Q*, Ji W*. Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. (2010) Proc. Natl. Acad. Sci. U. S. A. 107(41):17663-17667. doi: 10.1073/pnas.1006563107.
  40. Zhao XY, Lv Z, Li W, Zeng F*, Zhou Q*. Production of mice using iPS cells and tetraploid complementation. (2010) Nat. Protoc. 5(5):963-971. doi: 10.1038/nprot.2010.61.
  41. Liu L#, Luo GZ#, Yang W#, Zhao X#, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ*, Zhou Q*. Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. (2010) J. Biol. Chem. 285(25):19483-19490. doi: 10.1074/jbc.M110.131995.
  42. Dai X#, Hao J#, Hou XJ#, Hai T, Fan Y, Yu Y, Jouneau A, Wang L, Zhou Q*. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. (2010) J. Biol. Chem. 285(40):31002-31010. doi: 10.1074/jbc.M110.136085.
  43. Zhao XY#, Li W#, Lv Z#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F*, Zhou Q*. iPS cells produce viable mice through tetraploid complementation. (2009) Nature 461(7260):86-90. doi: 10.1038/nature08267.
  44. Andrews PW, Arias-Diaz J, Auerbach J, Alvarez M, Ahrlund-Richter L, Baker D, Benvenisty N, Ben-Josef D, Blin G, Borghese L, Borstlap J, Bruce K, Brüstle O, Buckle R, Camby C, Choo A, Chen W, Collins D, Colman A, Crombie C, Crook J, Cypess R, De Sousa P, Dhawan J, Douay L, Dvorak P, Dyke T, Eriksson L, Firpo M, Fitzgerald C, Glover C, Gokhale P, Greene M, Ha HY, Hampl A, Healy L, Hei D, Holm F, Hovatta O, Hunt C, Hwang SM, Inamdar M, Isasi R, Itskovitz-Eldor J, Jessie N, Kim DW, Kirzner R, Kiatpongsan S, Knowles B, Kuo HC, Laughlin M, Lavon N, Ludwig T, Lakov M, Lee DR, Macauley J, McKay R, Menasche P, Menendez P, Michalska A, Mileikovskaia M, Minger S, Mishra G, Moody J, Montgomery K, Morris C, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Nishikawa S, Oh S, Oh SK, Olson P, Otonkoski T, Patole M, Park HS, Pei X, Pera M, Puceat M, Rajala K, Reubinoff B, Robins A, Rooke H, Rumayor V, Scotman H, Sherlock J, Simon C, Sipp D, Skinner R, Smith D, Stacey G, Stefanovic S, Strehl R, Taft R, Takahashi T, Talib S, Terstegge S, Turner R, Tuuri T, Yu J, Zandstra P, Zapata A, Zeng F, Zhou Q, Tannenbaum S. Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. (2009) Stem Cell Rev. 5(4):301-314. doi: 10.1007/s12015-009-9085-x.
  45. Ma M#, Guo X#, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R*, Sha J, Zhou Q*. Protein expression profile of the mouse metaphase-II oocyte. (2008) J. Proteome Res. 7(11):4821-4830. doi: 10.1021/pr800392s.
  46. Mai Q#, Yu Y#, Li T, Wang L, Chen MJ, Huang SZ*, Zhou C*, Zhou Q*. Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. (2007) Cell Res. 17(12):1008-1019. doi: 10.1038/cr.2007.102.
  47. Zhou Q#*, Yang SH#, Ding CH#, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP*, Ji WZ*. A comparative approach to somatic cell nuclear transfer in the rhesus monkey. (2006) Hum. Reproduc. 21(10):2564-2571. doi: 10.1093/humrep/del216.
  48. Li T, Zheng J, Xie Y, Wang S, Zhang X, Li J, Jin L, Ma Y, Wolf DP, Zhou Q*, Ji W*. Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. (2005) Stem Cells 23(9):1295-1303. doi: 10.1634/stemcells.2005-0026.
  49. Zhou Q, Renard JP*, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J. Generation of fertile cloned rats by regulating oocyte activation. (2003) Science 302(5648):1179. doi: 10.1126/science.1088313.
  50. Zhou Q, Boulanger L, Renard JP*. A simplified method for the reconstruction of fully competent mouse zygotes from adult somatic donor nuclei. (2000) Cloning 2(1):35-44. doi: 10.1089/15204550050145111.