Location: Home > Scientists
  CAS Members
Name:
LIU, Yi-Xun
Subject:
Developmental Biology
Tel/Fax:
+86-10-64807038  / 
E-mail:
liuyx@ioz.ac.cn
Address:
The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
Group of Gonadal Biology      
Resume:

Professor Liu has spent more than 6 years in collaboration with distinguished scientists in UK, USA and Sweden since 1974 and made a great contribution in the research area of ovarian function and its regulation. He is the first to demonstrate that progesterone produced by granulosa cells (GC) can be used by theca-interstitial cells (TIs) to convert into androgen which has been known as the substrate of aromatases in GC, and he further demonstrated that interaction of GC and TI is the prerequisite for ovarian estrogen production; He is also the first to demonstrated that interaction of tissue type plasminogen activator (tPA) produced by GC/cumulus-oocyte complexes and plasminogen activator inhibitor type-1(PAI-1) secreted by TI, under the action of gonadotropins, induces ovulation. In recent years he has established primate models to study the action of heat stress on spermatogenesis. On the basis of this study he cloned 7 new spermatogenesis-related genes and exploded their main functions. Professor Liu has published more than 220 papers, of which 140 papers in SCI journals and well quoted by more than 1500 SCI papers. Because of his great contribution, he has been awarded with the CAS first class of Natural Science Prize once, and the Second Class of Natural Science Prize for 5 times. In 2005, he was awarded with the 5th “China Population Prize”. In 2006 he was awarded with “China Population and Family planning Science /Technology Prize”. In 2008, he was nominated as an outstanding teacher by the Science/Technology University of Chinese Academy of Sciences. At present 9 Ph.D students are in the Lab under supervision by Professor Liu, and more then 60 his postdocterial, Ph.D and Master students have graduated from the Lab.

Research Interests:

Awards and Honors:
  • Natural Science Award of Academia Sinica 1982 ( 2rd grade ) Preparation of Estrogen, Progesterone and Testosterone RIA kits for commercial use in China
  • Beijing Award of Science and Technology 1983 ( 3rd grade ) Studies on the Effect of Gossypol on anti-endometrisis
  • Natural Science Award of Academia Sinica 1984 ( 2rd grade ) Reproductive Physiology of Amphioxus
  • Natural Science Award of Academia Sinica 1985 ( 2rd grade ) Regulation and Extrapituitory Function of LH-RH and its Angonist
  • Natural Science Award of Academia Sinica 1991 ( 2rd grade ) Interaction and Regulation of Ovarian Granulosa and Theca-interstitial Cells
  • Natural Science Award of Academia Sinica 1993 ( 3rd grade ) The Role of Steroid and Steroid Receptors in the Precess of Implantation
  • Natioal Science Award of Academia. Sinica 1996 (2rd grade) Studies on the Role of tPA and PAI-1 in Regulation of Luteal Regression and Spermatogenesis
  • Science and Technology Award of State Family Planning Commission 1996 ( 2rd grade ) Studies on the Regulation of Follicle Development and Luteal Regression
  • Science and Technology Award of State Family Planning Commission 1996 ( 2rd grade) Studies on Epididymis factors Related to Sperm Maturation
  • Natural Science Award of Academia Sinica 1997 (First grade) Studies on the Mechanism of Ovulation
  • "the 5th China Population Award" 2005 (The highest Award in the field)
  • "China Population and Family Planning Science and Technology Award" 2006
  • "Outstanding Teacher Prize" 2008

Professional Activities:

Research Grants:
  • "973" Project: Molecular Basis of Heat Stress Action on Spermatogenesis and the Related Gene Clonning(2006CB504000)2006.10-2011.10
  • the Major Research Project:Molecular Mechanism of Oocyte Maturation and Ovulation (2006CB944001) 2006.10-2011.10
  • CAS Invention Project: Molecular Basis of Germ Cell Apoptosis (KSCX2-YW-R-55), 2006.12-2010.12
  • NSFC Major Project: Molecular Mechanism of Spermatogenesis and Maturation (30230190) 2003.12-2007.12
  • NSFC Major Research Project: Signaling Basis of Granulosa Cell Differentiation in the Ovary (90208025) 2003.1-2007.12
  • Hong Kong/NSFC SupportedProject: Study on Trs4 Function in Spermatogenesis by Conditional Knockout Mice (30618005), 2007.1-2009.12
  • NSFC General Project:
    1. Molecular Mechanism of Inhibitory Effect of Prolactin and Endomethecin on Ovulation in Rat and Mouse (30570921) 2006.1-2008.12
    2. Molecular Basis of Different Hormone Inducing Ovulation in Mammals (30370200) 2004.1-2006.12
    3. Mechanism of Wt1 Gene Regulating Sex Gene Sox9 Expression (30600311), 2007.1-2009.12
  • Beijing NSF Project: Role of TSNHE and Rsh12 in Sperm Movement (5073032) 2007.1-2009.12

Selected Publications:
  1. Myh11-Cre is not limited to peritubular myoid cells and interaction between Sertoli and peritubular myoid cells needs investigation. Proc Natl Acad Sci U S A. 2016 Apr 1. pii: 201602873. Corresponding author
  2. Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Cell Death Dis. 2016; 7:e2152. Corresponding author
  3. Melatonin promotes development of haploid germ cells from early developing spermatogenic cells of Suffolk sheep under in vitro condition. J Pineal Res. 2016. doi: 10.1111/jpi.12327 Corresponding author
  4. . Androgen receptor in Sertoli cells regulates DNA double-strand break repair and chromosomal synapsis of spermatocytes partially through intercellular EGF-EGFR signaling. Oncotarget. 2016. doi: 10.18632/oncotarget.7916. Corresponding author
  5. Development, function and fate of fetal Leydig cells. Semin Cell Dev Biol. 2016. pii: S1084-9521(16)30067-2.The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2' Biol Reprod 2013 88(3): 56. Corresponding author Corresponding author
  6. Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration  BMC Biol 2013 11(1): 22. Corresponding author Corresponding author
  7. Notch signaling is involved in ovarian follicle development by regulating granulosa cell proliferation. Endocrinology 2011; 152(6):2437-47. Corresponding author
  8. Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis. Endocrinology 2010 Feb;151(2):774-82. Corresponding author
  9. Effect of heat stress on expression of junction-associated molecules and upstream factor AR and WT1 in monkey Sertoli cells . Endocrinology 2008 Oct;149(10):4871-82.Corresponding author
  10. Heat treatment induces liver receptor homolog-1 expression in monkey and rat Sertoli cells. Endocrinology. 2007 148 (3):1255-1265. Corresponding author
  11. Dedifferentiation of Adult monkey Sertoli cells Through Activation of ERK1/2 Kinase Induced by Heat treatment ? Endocrinology. 2006, 147(3):1237-1245, Corresponding author
  12. Contraceptive action of a GnRH II analog in the rhesus monkey. J. Clin Endocrinol and Metab 2004, 89(9): 4513-4520  Co-corresponding author
  13. Tissue-type Plasminogen Activator and Its Inhibitor Plasminogen Activator Inhibitor Type 1 Are Coordinately Expressed during Ovulation in the Rhesus Monkey Endocrinology 2004: 145:1767-1775  First and corresponding Author
  14. Wt1 functions in ovarian follicle development by regulating granulosa cell differentiation. Hum Mol Genet. 2014; 23(2):333-41. corresponding Author
  15. Development of population and reproductive medicine in China 2003 : 266-283 in Science Progress in China, Eded by Lu Yongxiang, Science press 2003