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LIU Yixun
Developmental Biology
+86-10-64807038  / 
The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Group of Gonadal Biology      

Professor Liu has spent more than 6 years in collaboration with distinguished scientists in UK, USA and Sweden since 1974 and made a great contribution in the research area of ovarian function and its regulation. He is the first to demonstrate that progesterone produced by granulosa cells (GC) can be used by theca-interstitial cells (TIs) to convert into androgen which has been known as the substrate of aromatases in GC, and he further demonstrated that interaction of GC and TI is the prerequisite for ovarian estrogen production; He is also the first to demonstrated that interaction of tissue type plasminogen activator (tPA) produced by GC/cumulus-oocyte complexes and plasminogen activator inhibitor type-1(PAI-1) secreted by TI, under the action of gonadotropins, induces ovulation. In recent years he has established primate models to study the action of heat stress on spermatogenesis. On the basis of this study he cloned 7 new spermatogenesis-related genes and exploded their main functions. Professor Liu has published more than 220 papers, of which 140 papers in SCI journals and well quoted by more than 1500 SCI papers. Because of his great contribution, he has been awarded with the CAS first class of Natural Science Prize once, and the Second Class of Natural Science Prize for 5 times. In 2005, he was awarded with the 5th “China Population Prize”. In 2006 he was awarded with “China Population and Family planning Science /Technology Prize”. In 2008, he was nominated as an outstanding teacher by the Science/Technology University of Chinese Academy of Sciences. At present 9 Ph.D students are in the Lab under supervision by Professor Liu, and more then 60 his postdocterial, Ph.D and Master students have graduated from the Lab.

Research Interests:

Awards and Honors:
  • Natural Science Award of Academia Sinica 1982 ( 2rd grade ) Preparation of Estrogen, Progesterone and Testosterone RIA kits for commercial use in China
  • Beijing Award of Science and Technology 1983 ( 3rd grade ) Studies on the Effect of Gossypol on anti-endometrisis
  • Natural Science Award of Academia Sinica 1984 ( 2rd grade ) Reproductive Physiology of Amphioxus
  • Natural Science Award of Academia Sinica 1985 ( 2rd grade ) Regulation and Extrapituitory Function of LH-RH and its Angonist
  • Natural Science Award of Academia Sinica 1991 ( 2rd grade ) Interaction and Regulation of Ovarian Granulosa and Theca-interstitial Cells
  • Natural Science Award of Academia Sinica 1993 ( 3rd grade ) The Role of Steroid and Steroid Receptors in the Precess of Implantation
  • Natioal Science Award of Academia. Sinica 1996 (2rd grade) Studies on the Role of tPA and PAI-1 in Regulation of Luteal Regression and Spermatogenesis
  • Science and Technology Award of State Family Planning Commission 1996 ( 2rd grade ) Studies on the Regulation of Follicle Development and Luteal Regression
  • Science and Technology Award of State Family Planning Commission 1996 ( 2rd grade) Studies on Epididymis factors Related to Sperm Maturation
  • Natural Science Award of Academia Sinica 1997 (First grade) Studies on the Mechanism of Ovulation
  • "the 5th China Population Award" 2005 (The highest Award in the field)
  • "China Population and Family Planning Science and Technology Award" 2006
  • "Outstanding Teacher Prize" 2008

Professional Activities:

Research Grants:
  • "973" Project: Molecular Basis of Heat Stress Action on Spermatogenesis and the Related Gene Clonning(2006CB504000)2006.10-2011.10
  • the Major Research Project:Molecular Mechanism of Oocyte Maturation and Ovulation (2006CB944001) 2006.10-2011.10
  • CAS Invention Project: Molecular Basis of Germ Cell Apoptosis (KSCX2-YW-R-55), 2006.12-2010.12
  • NSFC Major Project: Molecular Mechanism of Spermatogenesis and Maturation (30230190) 2003.12-2007.12
  • NSFC Major Research Project: Signaling Basis of Granulosa Cell Differentiation in the Ovary (90208025) 2003.1-2007.12
  • Hong Kong/NSFC SupportedProject: Study on Trs4 Function in Spermatogenesis by Conditional Knockout Mice (30618005), 2007.1-2009.12
  • NSFC General Project:
    1. Molecular Mechanism of Inhibitory Effect of Prolactin and Endomethecin on Ovulation in Rat and Mouse (30570921) 2006.1-2008.12
    2. Molecular Basis of Different Hormone Inducing Ovulation in Mammals (30370200) 2004.1-2006.12
    3. Mechanism of Wt1 Gene Regulating Sex Gene Sox9 Expression (30600311), 2007.1-2009.12
  • Beijing NSF Project: Role of TSNHE and Rsh12 in Sperm Movement (5073032) 2007.1-2009.12

Selected Publications:
  1. Cheng JM1,2,3, Li J1,2, Tang JX1,2, Hao XX1,2, Wang ZP1,2, Sun TC1,2, Wang XX1, Zhang Y1, Chen SR1, Liu YX1. Merotelic Kinetochore Attachment in Oocyte Meiosis II Causes Sister Chromatids Segregation Errors in Aged Mice. 2017.16(15): 1404-1413
  2. Tang JX1,2, Li J1,2, Cheng JM1,2, Hu B3,4, Sun TC1,2, Li XY1,2, Batool A1,2, Wang ZP1,2, Wang XX1, Deng SL1, Zhang Y1, Chen SR1, Huang X3,4, Liu YX1,2. Requirement for CCNB1 in Mouse Spermatogenesis. 2017.8(10): E3142
  3. Jin C1,2, Zhang Y3,4, Wang ZP1,2, Wang XX1, Sun TC1,2, Li XY1,2, Tang JX1,2, Cheng JM1,2, Li J1,2, Chen SR1, Deng SL1, Liu YX3. EZH2 deletion promotes spermatogonial differentiation and apoptosis. 2017.154(5): 615-625
  4. Deng SL1, Sun TC2, Yu K3, Wang ZP1, Zhang BL4, Zhang Y1, Wang XX1, Lian ZX5, Liu YX6. Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen. 2017.113: 347-354
  5. Chen SR, Chen M, Deng SL, Hao XX, Wang XX, Liu YX. Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility.  Cell Death Dis.2016.7:E2152
  6. Deng SL, Chen SR, Wang ZP, Zhang Y, Tang JX, Li J, Wang XX, Cheng JM, Jin C, Li XY, Zhang BL, Yu K, Lian ZX, Liu GS, Liu YX. Melatonin promotes development of haploid germ cells from early developing spermatogenic cells of Suffolk sheep under in vitro condition. J Pineal Res. 2016. 60(4):435-47
  7. Chen SR, Hao XX, Zhang Y, Deng SL, Wang ZP, Wang YQ, Wang XX, Liu YX. Androgen receptor in Sertoli cells regulates DNA  double-strand break repair and chromosomal synapsis of spermatocytes partially through intercellular EGF-EGFR signaling.  Oncotarget. 2016. 7(14):18722-35
  8. Wen Q, Cheng CY, Liu YX. Development, function and fate of fetal Leydig cells. Semin Cell Dev Biol. 2016. 59:89-98
  9. Chen, S. R. and Liu, Y. X. Myh11-Cre is Not Limited to Peritubular Myoid Cells and Interaction Between Sertoli and Peritubular Myoid Cells Needs Investigation. Proc Natl Acad Sci U S A .2016.113(17): E2352