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  Principal Investigators
WANG Hongmei
Developmental Biology
+86-10-64807187  /  +86-10-64807189
The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Group of Reproductive Physiology      

Dr. Wang received her B.A. in Biology and a M.A. in Cell Biology from Beijing Normal University, a Ph.D. in Reproductive Physiology from The State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences and postdoctoral training in Dr. Benjamin K Tsang’s laboratory at Ottawa Health Research Institute. Dr. Wang is now a professor at the State Key Laboratory of Reproductive Biology and a recipient of “National Science Foundation for Distinguished Young Scholars”. She is working in the field of reproduction and developmental biology, where she has published over 50 peer-reviewed papers in the areas of embryo implantation, placentation and ovarian follicular development.

Research Interests:

Wang Lab is aimed at investigating the molecular mechanisms involved in placental development, particularly in the area of epithelial-mesenchymal transition (EMT), invasion/migration and syncytialization of the trophoblast lineage and placentation-related diseases, such as fetal growth restriction (FGR), pre-eclampsia and hydatidiform moles.

The overall goals of our research are: 1) to better understand the molecular events involved in placental trophoblast differentiation; 2) to provide potential biomarkers or candidate molecules for the diagnosis and treatment of pregnancy-related diseases including pre-eclampsia and FGR.

Placental villous trophoblast cells undergo terminal differentiation and fusion to form the multinucleated syncytiotrophoblast, while the extravillous cytotrophoblast infiltrates the endomyometrium to anchor the placenta. Inadequate/excessive invasion of trophoblast or dysregulation in syncytialization results in early pregnancy loss, pre-eclampsia, fetal growth restriction (FGR), hydatidiform moles or choriocarcinomas. The main research interest of my laboratory is to study the physiological and pathological mechanisms of placentation and related diseases, especially the key events including trophoblast invasion/migration and syncytialization. For many years, my lab has been working on key factors/pathways involved in embryo implantation and placentation, and has gained valuable information of the important functions of the ubiquitin-proteasome pathway, TGF-β signaling pathway, proprotein convertases and corticosteroid-binding globulin (CBG) in embryo implantation and placentation. By combining placenta-specific knockout or knockdown, gene nucleotide polymorphism analysis and cutting-edge molecular methods, we are continuing to uncover novel mechanisms involving the aforementioned factors and pathways in placentation.

Awards and Honors:

Professional Activities:

Research Grants:

National Science Fund for Distinguished Young Scholars Project: Pregnancy and pregnancy-related diseases (2013-2016);

NSFC Project: Effects of single nucleotide polymorphisms on gene transcription and protein function of syncytin-1 and -2, essential molecules for placental syncytialization and linkage to pregnancy outcome (2013-2016);

NSFC Project: The role of furin in trophoblast syncytialization and the underlying molecular mechanism (2012-2015);

NSFC-CIHR International Cooperation Project: Control of progesterone bioavailability at the maternal-fetal interface: relationship to pregnancy outcome (2012-2014);

National Basic Research Program of China: Molecular basis of pregnancy establishment and maintenance (2011-2015);

Project from the CAS: Cellular aspects of somatic cell reprogramming (2011-2015).

Selected Publications:
  1. Liu YW#, Fan XY#, Wang R#, Lu XY#, Dang YL, Wang HY, Lin HY, Zhu C, Ge H, Cross JC*, Wang H* Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Reseach, 2018, 28(8):819-832. https://f1000.com/prime/733692041?bd=1  
  2. Chang WL#, Liu YW#, Dang YL#, Jiang XX, Xu HL, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng WX*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development, 2018,145(2).
  3. Lu XY#, Wang R#, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Reports. 2017, 21(5), 1150-1159.
  4. Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017,(6), e26248.
  5. Zhang Y#, Wang Q#, Wang H*, Duan EK*. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends in Molecular Medicine. 2017, 23(7), 604–614.
  6. Aguilar PS#, Baylies MK#, Fleissner A#, Helming L#, Inoue N#, Podbilewicz B*, Wang H#, Wong M#. Genetic basis of cell–cell fusion mechanisms. Trends Genet, 2013, 29(7), 427-437. (#, equal contribution.) (invited review)