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  Principal Investigators
Developmental Biology
+86-010-64807299  /  +86-10-64807306
The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Group of Reproductive Engineering      
Qi Zhou,Ph.D.,is a Professor at the Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS). He received hisPhD in Histology and Embryology in 1996 from Northeast Agriculture University, China, and held a postdoctoral fellow and then an associate professor position from 1997-1999 at the Institute of Developmental Biology, CAS. He was a postdoctoral fellow and project leader at the French National Institute for Agricultural Research (INRA) from 1999-2002. He is currently the director of the State Key Laboratory of Stem Cell and Reproductive Biology, deputy director of the IOZ. In 2015, Prof. Zhou was elected as a CAS Member.

Research Interests:
Prof. Zhou’s research include the mechanisms of cell reprogramming, differentiation and de-differentiation, and cell fate control, obtaining and maintenance of stem cell pluripotency, etc. In addition, he establishes animal models, including mouse, rat, porcine, primate, and cell models for studying human diseases. He is also dedicated to promoting the application of stem cells to clinical use.

Awards and Honors:
2014: Second Class Award of National Natural Science Award, China, the First Contributor
2014/2012/2010: Excellent Mentor Award, CAS
2013: CAS International Cooperation Award for Young Scientists, with Dr.Nathalie Beaujean
2013: Outstanding Science and Technology Achievement Prize of the CAS, Principal Contributor
2013: Tan Jiazhen Life Sciences Innovation Award
2011: Award for Outstanding Youth in Basic Science, Zhou Guang Zhao Foundation
2010: Prize for Scientific and Technological Progress, Ho Leung Ho Lee Foundation
2007: China Youth May 4th Medal
2006: 9th National Science and Technology Award for Young Scientists, China
2005: Recipient of the National Science Fund for Distinguished Young Scholars
2004: 3rdgenOway Prize for Transgenic Technologies, International Society for Transgenic Technologies
2002: PRIX AFCRST Le Prix Tang Freres Biotechnologie, France
2001: Hundred Talents Program of the Chinese Academy of Sciences

Professional Activities:
  • Deputy Dean of the University of Chinese Academy of Sciences
  • Rotating President of the International Stem Cell Forum (2014- )
  • Member of the Annual Meeting Program Committee of the International Society for Stem Cell Research (ISSCR) (2014-2015)
  • Vice President of the Chinese Society for Cell Biology
  • President of the Chinese Society for Stem Cell Research
  • Deputy President of the Chinese Society of Tissue Repairing and Regeneration, Chinese Medical Association
  • Director of the Chinese Society of Cellular Biology, Chinese Medical Association
  • Standing Director of the China Zoological Society
  • Director of the Chinese Association for Laboratory Animal SciencesEditorial Board: Journal of Biological Chemistry, Protein & Cell, Nature partner journal Regenerative Medicine, National Science Review, Signal Transduction and Targeted Therapy

Research Grants:
  • General Program of National Natural Science Foundation of China, 2015-2018
  • Major Research Plan of the National Natural Science Foundation of China, 2014-2016
  • National Major Scientific Research Projects, 2012-2016
  • Stem Cells and Regenerative Medicine. Strategic Priority Research Program of the Chinese Academy of Sciences, 2011-2015

Selected Publications:
  1. Cui T#, Jiang L#, Li T#, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W*, Zhou Q*. (2019) Derivation of Mouse Haploid Trophoblast Stem Cells. Cell Rep. 26(2):407-414.e5. doi: 10.1016/j.celrep.2018.12.067.
  2. Li Y#, Wang L#, Zhang L#, He Z#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. (2019) Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. J Cell Biol. doi: 10.1083/jcb.201808088.
  3. Teng F#, Li J#, Cui T#, Xu K, Guo L, Gao Q, Feng G, Chen C, Han D, Zhou Q*, Li W*. (2019) Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds. Genome Biol.;20(1):15. doi: 10.1186/s13059-019-1620-8.
  4. Wang J#, Wang L#, Feng G#, Wang Y#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. (2018) Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell 2018 Dec 13;175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.
  5. Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. (2018) Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell 23(5):665-676. 
  6. Li X#, Cui XL#, Wang JQ#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. (2016) Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 164(1-2):279–292.
  7. Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W*, Zhou Q*, Hu B*. (2016) Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res. 26(1):135-138.
  8. Zhou Q#, Wang M#, Yuan Y#, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY*, Sha J*, Zhou Q* (2016) Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. Cell Stem Cell 18(3):330-340.
  9. Chen Q#*, Yan M#, Cao Z#, Li X#, Zhang Y#, Shi J#, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. (2016) Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science351(6271):397-400.
  10. Wan H#, Feng C#, Teng F#, Yang S#, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W*, Zhao X*, Zhou Q*. (2015)One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res. 25(2):258-261.
  11. Chen Y#, Niu Y#, Li Y#, Ai Z, Kang Y, Shi H, Xiang Z, Yang Z, Tan T, Si W, Li W, Xia X, Zhou Q*, Ji W*, Li T*. (2015)Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell Stem Cell 17(1):116-124.
  12. Chen T#, Hao YJ#, Zhang Y#, Li MM#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG*, Zhou Q*. (2015)m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 16(3):289-301.
  13. Li X#, Wang JQ#, Wang LY#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q*. (2015) Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. J Mol Cell Biol. 7(5):486-488.
  14. Shuai L#, Wang Y#, Dong M#, Wang X#, Sang L, Wang M, Wan H, Luo G, Gu T, Yuan Y, Feng C, Teng F, Li W, Liu X, Li T, Wang L, Wang XJ, Zhao XY, Zhou Q*. (2015) Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro. J Mol Cell Biol. 7(4):326-337.
  15. Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W,Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q. (2015)CRISPR germline engineering—the community speaks. Nat. Biotechnol. 33(5):478-486.
  16. Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi Y-M, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha H-Y, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang S-M, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo S-K, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh S-K, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN*, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan B-Z, Zeng F, Zhou Q. (2015)Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI). Regen. Med. 10(2s):1-44.
  17. Wang J#, Hao J#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z*, Zhou Q*. (2015) Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions.Stem Cell Res Ther. 2015 Nov 12;6(1):223. doi: 10.1186/s13287-015-0206-y.
  18. Li W#, Li X#, Li T#, Jiang MG#, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q*. (2014)Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 14(3):404-414.
  19. Hai T#, Teng F#, Guo R, Li W, Zhou Q*. (2014)One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res. 24(3):372-375.
  20. Zhou Q*. (2014)Balancing the welfare: the use of non-human primates in research. Trends Genet. 30(11):476-478.
  21. Gu Q#, Hao J#, Hai T#, Wang J#, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. (2014)Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. Protein Cell. 5(5):338-342.
  22. Li W#, Teng F#, Li T, Zhou Q*. (2013)Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat. Biotechnol.31(8):684–686.
  23. Wan H#, He Z#, Dong M, Gu T, Luo GZ, Teng F, Xia B, Li W, Feng C, Li X, Li T, Shuai L, Fu R, Wang L, Wang XJ, Zhao XY*, Zhou Q*. (2013)Parthenogenetic haploid embryonic stem cells produce fertile mice. Cell Res. 23(11):1330-1333.
  24. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ*, Zhou Q*. (2013)MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. J Biol. Chem. 288(33):23659–23665.
  25. Li W#, Shuai L#, Wan H#, Dong M#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. (2012)Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490(7420):407-411.
  26. Sheng C#, Zheng Q#, Wu J#, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z*, Zhou Q*. (2012)Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res. 22(1):208-218.
  27. Sheng C#, Zheng Q#, Wu J#, Xu Z, Sang L, Wang L, Guo C, Zhu W, Tong M, Liu L, Li W, Liu ZH, Zhao XY, Wang L, Chen Z*, Zhou Q*. (2012)Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors. Cell Res.22(4):769-772.
  28. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. (2012)Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. Protein Cell.3(1):71-79.
  29. Tong M#, Lv Z#, Liu L#, Zhu H#, Zheng QY#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng F, Wang L, Wang XJ, Sha JH*, Zhou Q*. (2011)Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. Cell Res.21(11):1634-1637.
  30. Li W#, Zhao XY#, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L*, Zhou Q*. (2011)iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Res.21(3):550-553.
  31. Riaz A#, Zhao X#, Dai X#, Li W, Liu L, Wan H, Yu Y, Wang L, Zhou Q*. (2011)Mouse cloning and somatic cell reprogramming using electrofusedblastomeres. Cell Res. 21(5):770-778.
  32. Yu Y#, Yan J#, Liu ZC#, Yan LY, Li M, Zhou Q*, Qiao J*. (2011)Optimal timing of oocyte maturation and its relationship with the spindle assembly and developmental competence of in vitro matured human oocytes. Fertil.Steril. 96(1):73-78.
  33. Yu Y#, Zhao C#, Lv Z, Chen W, Tong M, Guo X, Wang L, Liu J, Zhou Z, Zhu H*, Zhou Q*, Sha J. (2011)Microinjection manipulation resulted in the increased apoptosis of spermatocytes in testes from intracytoplasmic sperm injection (ICSI) derived mice. PLoS One 6(7):e22172.
  34. Niu Y#, Yu Y#, Bernat A#, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P*, Zhang K*, Zhou Q*, Ji W*. (2010)Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. Proc. Natl. Acad. Sci. U. S. A. 107(41):17663-17667.
  35. Zhao XY, Lv Z, Li W, Zeng F*, Zhou Q*. (2010)Production of mice using iPS cells and tetraploid complementation. Nat.Protoc.5(5):963-971.
  36. Liu L#, Luo GZ#, Yang W#, Zhao X#, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ*, Zhou Q*. (2010)Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J. Biol. Chem. 285(25):19483-19490.
  37. Maruotti J#, Dai XP#, Brochard V, Jouneau L, Liu J, Bonnet-Garnier A, Jammes H, Vallier L, Brons IG, Pedersen R, Renard JP, Zhou Q*, Jouneau A*. (2010)Nuclear transfer-derived epiblast stem cells are transcriptionally and epigenetically distinguishable from their fertilized-derived counterparts. Stem Cells 28(4):743-752.
  38. Dai X#, Hao J#, Hou XJ#, Hai T, Fan Y, Yu Y, Jouneau A, Wang L, Zhou Q*. (2010)Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. J. Biol. Chem. 285(40):31002-31010.
  39. Zhao XY#, Li W#, Lv Z#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F*, Zhou Q*. (2009)iPS cells produce viable mice through tetraploid complementation. Nature 461(7260):86-90.
  40. Dai XP, Hao J, Zhou Q*. (2009)A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos. Reproduction 138(2):301-308.
  41. Andrews PW, Arias-Diaz J, Auerbach J, Alvarez M, Ahrlund-Richter L, Baker D, Benvenisty N, Ben-Josef D, Blin G, Borghese L, Borstlap J, Bruce K, Brüstle O, Buckle R, Camby C, Choo A, Chen W, Collins D, Colman A, Crombie C, Crook J, Cypess R, De Sousa P, Dhawan J, Douay L, Dvorak P, Dyke T, Eriksson L, Firpo M, Fitzgerald C, Glover C, Gokhale P, Greene M, Ha HY, Hampl A, Healy L, Hei D, Holm F, Hovatta O, Hunt C, Hwang SM, Inamdar M, Isasi R, Itskovitz-Eldor J, Jessie N, Kim DW, Kirzner R, Kiatpongsan S, Knowles B, Kuo HC, Laughlin M, Lavon N, Ludwig T, Lakov M, Lee DR, Macauley J, McKay R, Menasche P, Menendez P, Michalska A, Mileikovskaia M, Minger S, Mishra G, Moody J, Montgomery K, Morris C, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Nishikawa S, Oh S, Oh SK, Olson P, Otonkoski T, Patole M, Park HS, Pei X, Pera M, Puceat M, Rajala K, Reubinoff B, Robins A, Rooke H, Rumayor V, Scotman H, Sherlock J, Simon C, Sipp D, Skinner R, Smith D, Stacey G, Stefanovic S, Strehl R, Taft R, Takahashi T, Talib S, Terstegge S, Turner R, Tuuri T, Yu J, Zandstra P, Zapata A, Zeng F, Zhou Q, Tannenbaum S. (2009)Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. Stem Cell Rev. 5(4):301–314.
  42. Ma M#, Guo X#, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R*, Sha J, Zhou Q*. (2008)Protein expression profile of the mouse metaphase-II oocyte.J. Proteome Res. 7(11):4821-4830.
  43. Wang S#, Shen Y#, Yuan X, Chen K, Guo X, Chen Y, Niu Y, Li J, Xu RH, Yan X*, Zhou Q*, Ji W*. (2008)Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells. J. Biol. Chem.283(51):35929-35940.
  44. Mai Q#, Yu Y#, Li T, Wang L, Chen MJ, Huang SZ*, Zhou C*, Zhou Q*. (2007)Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Res.17(12):1008-1019.
  45. Yang J, Yang S, Beaujean N, Niu Y, He X, Xie Y, Tang X, Wang L, Zhou Q*, Ji W*. (2007)Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro. Biol.Reproduc.76(1):36-42.
  46. Yang S*, He X, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Zhou Q*, Ji W*. (2007)Effects of rhFSH dose on ovarian follicular response, oocyte recovery and embryo development in rhesus monkeys. Theriogenology67(6):1194-1201.
  47. Zhou Q#*, Yang SH#, Ding CH#, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP*, Ji WZ*. (2006)A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Hum.Reproduc. 21(10):2564-2571.
  48. Li T, Zheng J, Xie Y, Wang S, Zhang X, Li J, Jin L, Ma Y, Wolf DP, Zhou Q*, Ji W*. (2005)Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. Stem Cells 23(9):1295-1303.
  49. Zhou Q, Renard JP*, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J. (2003)Generation of fertile cloned rats by regulating oocyte activation. Science 302(5648):1179.
  50. Zhou Q, Boulanger L, Renard JP*. (2000)A simplified method for the reconstruction of fully competent mouse zygotes from adult somatic donor nuclei. Cloning 2(1):35-44.