Location: Home > Scientists
  Principal Investigators
Name:
SUN Qingyuan
Subject:
Developmental Biology
Tel/Fax:
+86-10-64807050  / 
E-mail:
sunqy@ioz.ac.cn, sunqy1@yahoo.com
Address:
The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences,1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
More:
Division of Fertilization Biology      
Resume:
Education and Training:
Ph.D. in embryology, Northeast Agricultural University (1991-1994);
Post-doc, Institute of Zoology, Chinese Academy of Sciences (1994-1996);
Post-doc, Bar-Ilan University, Israel (1996-1998);
Research associate, University of Missouri-Columbia, USA (1999-2001);
STA fellow, National Institute of Animal Industry, Japan (1996);
Invited JSPS fellow, National Institute of Agrobiological Sciences, Japan (2003); Visiting professor, University of Missouri-Columbia, USA (2005);
Invited JSPS fellow, National Institute of Agrobiological Sciences, Japan (2008);
Visiting professor, University of Missouri-Columbia, USA (2009).

Current Positions:
Professor (since 1998) State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences;
President, China Society for Reproductive Biology;
President, China Society for Cellular and Molecular Microscopy.
Deputy president, Chinese Society for Zoology

Research Interests:
Oogenesis, oocyte meiotic maturation and fertilization;
Epigenetics in reproduction.

Current Editorial Board:
Biology of Reproduction
Cell Cycle
Molecular Reproduction and Development
Reproduction Fertility and Development
Journal of Reproduction and Development
Asian Journal of Andrology
Journal of Genetics and Genomics
PLoS One
Peer J
The Scientific World Journal
Progress in Biophysics and Biochemistry
Current Zoology
Chinese Journal of Cell Biology,
Chinese Journal of Zoology
Chinese Journal of Reproductive Medicine
Reproduction and Contraception
Molecular Human Reproduction

Awards and Honors:
Distinguished Young Scientist of The Chinese Academy of Sciences (1999);
Grants for Outstanding Young Scientists from National Natural Science Foundation of China (2002);
National Award for Distinguished Scholars Returned From Abroad (2003);
Distinguished Youth of The Chinese Academy of Sciences (2003);
National Award for Outstanding Young Scientists (2004);
National Award for Outstanding Post-Docs (2006);
National Natural Science Prize (Second) (2006)
BHP Billiton Supervisor Research Award, Graduate School of Chinese Academy of Sciences (2007)
The Outstanding Researcher during the National 11th Five-Year Plan, Ministry of Science and Technology (2011)
The First Prize for Science and Technology Progress, National Population and Family Planning Council (2011)

Professional Activities:

Research Grants:

Selected Publications:
Authored or c-authored more than 330 papers in peer-review internationals journals with more than 7000 citations and H index of 43. The following is the list of recent representative publications (* correspondence):
  1. Zhang T, Zhou Y, Li L, Wang ZB, Shen W, Schatten H, Sun QY*. CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes. Development. 2016 Dec 19. pii: dev.141135. [Epub ahead of print]
  2. Wang HH, Cui Q, Zhang T, Guo L, Dong MZ, Hou Y, Wang ZB, Shen W, Ma JY, Sun QY*. Removal of mouse ovary fat pad affects sex hormones, folliculogenesis and fertility. J Endocrinol. 2017 Feb;232(2):155-164.
  3. Hu MW, Meng TG, Jiang ZZ, Dong MZ, Schatten H, Xu X*, Wang ZB*, Sun QY*. Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. 2016 Dec 8;12(12):e1006513. doi: 10.1371/journal.pgen.1006513.
  4. Liu K, Zhao Q, Liu P, Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S,Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou Q, Zhao T. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy. 2016 Nov;12(11):2000-2008.
  5. Qi ST, Ma JY, Wang ZB, Guo L, Hou Y, Sun QY*. N6-methyladenosine seqencing highlights the involvement of mRNA methylation in oocyte meiotic maturation and embryo development by regulating translation in Xenopus laevis. J Biol Chem. 2016 Oct 28;291(44):23020-23026.
  6. Ma XS, Lin F, Wang ZW, Hu MW, Huang L, Meng TG, Jiang ZZ, Schatten H, Wang ZB*, Sun QY*. Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility. Mol Biol Cell. 2016, 27(5):768-75.
  7. Wang ZB, Ma XS, Hu MW, Jiang ZZ, Meng TG, Dong MZ, Fan LH, Ouyang YC, Snapper SB, Schatten H, Sun QY*. Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion. Mol Hum Reprod. 2016 Sep;22(9):613-21.
  8. Yu C, Ji SY, Sha QQ, Wang ZW, Sun QY, Fan HY.  BTG4 is a meiotic cell cycle-coupled maternal-zygotic tansition licensing factor in oocytes. Nature Structural and Molecular Biology 2016 May;23(5):387-94.
  9. Jiang ZZ, Hu MW, Ma XS, Schatten H, Fan HY, Wang ZB, Sun QY*. LKB1 acts as a critical gatekeeper of ovarian primordial follicle pool. Oncotarget. 2016, 7(5):5738-53.
  10. Zhang T, Zhou Y, Li L, Wang HH, Ma XS, Qian WP, Shen W, Schatten H, Sun QY*. SIRT1, 2, 3 protect mouse oocytes from postovulatory aging. Aging (Albany NY). 2016, 8(4):685-96.
  11. Ma XS, Lin F, Wang ZW, Hu MW, Huang L, Meng TG, Jiang ZZ, Schatten H, Wang ZB, Sun QY*. Geminin Deletion in Mouse Oocytes Results in Impaired Embryo Development and Reduced Fertility. Mol Biol Cell. 2016 Jan 13. pii: mbc.E15-06-0346. [Epub ahead of print]
  12. Yu C, Ji SY, Sha QQ, Sun QY, Fan HY. CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation. Nat Communications. 2015 Aug 18;6:8017.
  13.  Hu MW, Wang ZB, Teng Y, Jiang ZZ, Ma XS, Hou N, Cheng X, Schatten H, Xu X*, Yang X*, Sun QY*. Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility. J Cell Sci. 2015 Oct 15;128(20):3769-80. (Commented in this issue, cover paper)
  14. Wei Y, Yang CR, Wei YP, Ge ZJ, Zhao ZA, Zhang B, Hou Y, Schatten H, Sun QY*. Enriched Environment-Induced Maternal Weight Loss Reprograms Metabolic Gene Expression in Mouse Offspring. J Biol Chem. 2015, 20;290(8):4604-19.
  15. Wei YC,Schatten H, Sun QY*. Environmental epigenetic inheritance through gametes and implications for human reproduction. Hum Reprod Update 2015 Mar-Apr;21(2):194-208
  16. Wei Y, Yang CR, Wei YP, Zhao ZA, Hou Y, Schatten H, Sun QY*. Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals. Proc Natl Acad Sci USA PNAS 111(5):1873-1878, 2014
  17. Yu XJ, Yi Z, Gao Z, Qin DD, Zhai Y, Chen X, Ou-Yang YC, Wang ZB, Zheng P, Zhu MS, Wang H, Sun QY Dean J, Li L. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nature Communications 2014 Sep 11;5:4887.
  18. Ge ZJ, Luo SM, Lin F, Liang QX, Huang L, Wei YC, Hou Y, Han ZM, Schatten H, Sun QY*. DNA methylation in oocytes and liver of female mice and their offspring: Effects of high-fat-diet-induced obesity. Environmental Health Perspectives 122(2):159-164, 2014.
  19. Jiang ZZ, Hu MW, Wang ZB, Huang L, Lin F, Qi ST, Ouyang YC, Fan HY, Schatten H, Mak TW, Sun QY*. Survivin is essential for fertile egg production and female fertility in mice. Cell Death Dis. 2014 Mar 27;5:e1154. doi: 10.1038/cddis.2014.126.
  20. Ge ZJ, Zhang CL, Schatten H, Sun QY*. Maternal diabetes mellitus and the origin of non-communicable diseases in offspring: the role of epigenetics. Biol Reprod. 2014 May 14. pii: biolreprod.114.118141. [Epub ahead of print]
  21. Lin F, Ma XS, Wang ZB, Wang ZW, Luo YB, Huang L, Jiang ZZ, Hu MW, Schatten H, Sun QY*. Different fates of oocytes with DNA double-strand breaks in vitro and in vivo. Cell Cycle 2014, 13(17): in press.
  22. Hu MW, Wang ZB, Jiang ZZ, Qi ST, Huang L, Liang QX, Schatten H, Sun QY*. Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility. Biol Reprod. 2014 Jun 4. pii: biolreprod.114.120220. [Epub ahead of print]
  23. Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y, Wei YC, Yan J, Wang WH, Shen W, Sun SC, Schatten H, Sun QY*. The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects. Molecular Aspects of Medicine 2013 Jun 21. doi:pii: S0098-2997(13)00041-1. 10.1016/j.mam.2013.06.001. [Epub ahead of print], 2014
  24. Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY*, Fan HY*. CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science  342:1518-21,2013. Highlighted by Biol Reprod, 2014
  25. Wang ZB, Jiang ZZ, Zhang QH, Hu MW, Huang L, Ou XH, Guo L, Ouyang YC, Hou Y, Brakebusch C, Schatten H, Sun QY*. Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation, but disrupts polarity establishment and cytokinesis in mouse oocyte. Molecular Biology of the Cell 24: 3832-3841, 2013.
  26. Luo SM, Ge ZJ, Wang ZW, Jiang ZZ, Wang ZB, Ouyang YC, Hou Y, Schatten h, Sun QY*. Unique insights into maternal mitochondrial inheritance in mice. Proc Natl Acad Sci USA PNAS110(32):13038-13043, 2013.
  27. Wang ZW, Ma XS, Ma JY, Luo YB, Lin F, Wang ZB, Schatten H, Fan Hy, Sun QY*. Laser Microbeam-Induced DNA Damage Inhibits Cell Division in Fertilized Eggs and Early Embryos. Cell Cycle 12(20):3336-3344,2013.
  28. Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun QY, Li L, Yang X, Fan ZWASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO Journal. 32(20):2685-2696,2013.
  29. Ma JY, Li M, Luo YB, Song S, Tian D, Yang J, Zhang B, Hou Y, Schatten H, Liu Z, Sun QY*. Maternal factors required for oocyte developmental competence in mice: Transcriptome analysis of non-surrounded nculeolus (NSN) and surrounded nucleolus (SN) oocytes. Cell Cycle. 12:1928-1938, 2013.
  30. Qi ST, Wang ZB, Ouyang YC, Zhang QH, Hu MW, Huang X, Ge ZJ, Guo L, Wang YP, Hou Y, Schatten H, Sun QY* Overexpression of SETβ, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocyte. Journal of Cell Science 126, 1595-1603, 2013.
  31. Luo YB, Ma JY, Zhang QH, Lin F, Wang ZW, Huang L, Schatten H, Sun QY*. MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation. Cell Cycle. 12(7): 1142-1150, 2013.
  32. Ma JY, Ouyang YC, Luo YB, Wang ZB, Hou Y, Han ZM, Liu ZH, Schatten H, Sun QY*Cyclin O regulates germinal vesicle breakdown in mouse oocytes. Biology of Reproduction, 88(5):110, 1-9, 2013.
  33. Ge ZJ, Liang XW, Guo L, Liang QX, Luo SM, Wang YP, Wei YC, Han ZM, Schatten H, Sun QY* Maternal diabetes causes alterations of DNA imprinting in murine oocytes. Biology of Reproduction, 88(5):117, 1-9, 2013.
  34. Reported by Science Daily, Science News, Medical News Today, Medical Express, MedSci
  35. Ma JY, Ouyang YC, Wang ZW, Wang ZB, Jiang ZZ, Luo SM, Hou Y, Liu ZH, Sun QY* The effects of DNA double-strand breaks on mouse oocyte meiotic maturation. Cell Cycle 12(8): 1928-1938, 2013.
  36. Yang SW, Gao C, Chen L, Song YL, Zhu JL, Qi ST, Jiang ZZ, Wang ZW, Lin F, Huang H, Xing FQ, Sun QY* Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis. Cell Cycle 16;11(23):4366-77,2012.
  37. Ma JY, Liang XW, Schatten H, Sun QY* Active DNA demethylation in mammalian preimplantation embryos: new insights and new perspectives. Molecular Human Reproduction. 18(7):333-40,2012.Cover paper
  38. Ou XH, Li S, Wang ZB, Li M, Quan S, Xing F, Chao SB, Chen ZJ, Liang XW, Hou Y, Schatten H, Sun QY*. Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes. Human Reproduction 27(7):2130-45,2012.
  39. Li S, Ou XH, Wei L, Wang ZB, Zhang QH, Ouyang YC, Hou Y, Schatten H, Sun QY*. Septin 7 is required for orderly meiosis in mouse oocytes. Cell Cycle. 11(17):3211-8,2012.
  40. Chen L, Chao SB, Wang ZB, Qi ST, Zhu XL, Yang SW, Yang CR, Zhang QH, Ouyang YC, Hou Y, Schatten H,Sun QY*  Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes. Cell Cycle 15;11(10):1948-55, 2012.
  41. Chao SB, Guo l, Ou XH, Luo SM, Wang ZB, Schatetn H, Gao l, Sun QY*  Heated spermatozoa: effects on embryonic development and epigenetics. Human Reproduction 27(4):1016-24,2012.
  42. Zhang QH, Qi ST, Wang ZB, Yang CR, Wei YC, Chen L, OuYang YC, Hou Y, Schatetn H, Sun QY* Localization and function of the Ska complex during mouse oocyte meiotic maturation. Cell Cycle 11(5):909-16, 2012.
  43. Zhu XL, Qi ST, Liu J, Chen L, Zhang C, Yang SW, OuYang YC, Hou Y, Schatten H, Sun QY* Synaptotagmin1 is required for spindle stability and metaphase-anaphase transition in mouse oocytes. Cell Cycle 11(4):818-26, 2012.
  44. Wang ZB, Schatten H, Sun QY* Why is chromosome segregation rrror in oocytes increased with maternal aging? Physiology 26:314-325, 2011.cover paper
  45. Liang XW, Ge ZJ, Guo L, Luo SM, Han ZM, Schatten H, Sun QY* Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes. Fertility and Sterility.96: 1479-1484, 2011.
  46. Zhang CH, Wang ZB, Quan S, Huang X, Tong JS, Ma JY, Guo L, Wei YC, Ouyang YC, Hou Y, Xing FQ, Sun QY* GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte. Cell Cycle 10(11):2230-2236, 2011.
  47. (Commented by Sun SC in Cell Cycle, 2011; Liu XJ in Cell Cycle, 2011)
  48. Liang XW, Ge ZJ, Wei L, Guo L, Han ZM, Schatten H, Sun QY* The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation. Molecular Human Reproduction 17:562-567, 2011.
  49. Schatten H*, Sun QY* The role of centrosomes in fertilization, cell division and establishment of asymmetry during embryo development. Seminars in Cell & Developmental Biology. 21:174-184, 2010.
  50. Gu L, Wang Q*, Sun QY* Histone modifications during mammalian oocyte maturation: dynamics, regulation, and functions. Cell Cycle 23;9(10):1942-1950, 2010.
  51. Ou XH, Li S, Xu BZ, Wang ZB, Quan S, Li M, Zhang QH, Ouyang YC, Schatten H, Xing FQ*, Sun QY* p38α MAPK Is a MTOC-Associated Protein Regulating Spindle Assembly, Spindle Length and Accurate Chromosome Segregation during Mouse Oocyte Meiotic Maturation. Cell Cycle 9:4130-4143, 2010. (Faculty of 1000)
  52. Wang ZB, Ou XH, Tong JS, Li S, Wei l, Ouyang YC, Hou Y, Schatten H, Sun QY * The SUMO pathway functions in mouse oocyte maturation. Cell Cycle 9(13):2640-2046, 2010.
  53. Qiao J, Chen Y, Yan LY, Yan J, Liu P, Sun QY. Changes in histone methylation during human oocyte maturation and IVF- or ICSI-derived embryo development. Fertil Steril. 93(5):1628-36, 2010
  54. Zhang QH, Wei L, Tong JS, Qi ST, Li S, Ou XH, Ouyang YC, Hou Y, An LG, Schatten H, Sun QY* Localization and function of mSpindly during mouse oocyte meiotic maturation. Cell Cycle 9(11):2230-2236,2010.
  55. Zhu JL, Lin SL, Li m, Ouyang YC, Hou Y, Schatten H, Sun QY* Septin2 is modified by SUMOylation and required for chromosome congression in mouse oocytes. Cell Cycle 9(8) 1607-1616,2010.
  56. Sha W, Xu BZ, Li M, Liu D, Feng HL, Sun QY* Impact of gonadotrophins on oocyte maturation in vitro: An animal model. Fertility and Sterility 93(5):1650-1661, 2010.
  57. Wei L, Liang XW, Zhang QH, Li M, Yuan J, Li S, Sun SC, Ouyang YC, Schatten H, Sun QY* BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte. Cell Cycle 9(6) 1112-1121, 2010.
  58. (Cover paper, commented by Fan HY. Cell Cycle. 2010 Apr 15;9(8); Jones KT, Holt JE. Cell Cycle. 2010 Mar 15;9(6))
  59. Ma CH, Yan LY, Qiao J, Sha W, Li L, Chen Y, Sun QY Effects of tumor necrosis factor-alpha on porcine oocyte meiosis progression, spindle organization, and chromosome alignment. Fertil Steril. 93:920-926, 2010.
  60. Sun QY*, Miao YL, Schatten H* Towards a new understanding on the regulation of mammalian oocyte meiosis resumption. Cell Cycle 8(17):2741-7, 2009.
  61. Miao YL, Kikuchi K, Sun QY*, Schatten H*  Oocyte aging: implications for developmental potential, and practical significance for assisted reproduction technologies. Human Reproduction Update 15:573-585, 2009.(cover paper)
  62. Yuan J, Sun QY*. Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes. Cell Cycle 8(20) 3384-3395, 2009.
  63. Yan LY, Qiao J, Chen Y, Huang J, Liu P, Sun QY Application of 3D- fluorescence in situ hybridization to human preimplantation genetic diagnosis. Fertility and Sterility 92(4):1492-5, 2009.
  64. Sun SC, Wei L, Li M, Lin SL, Xu BZ, Liang XW, Kim NH, Schatten H, Lu SS, Sun QY* Perturbation of survivin expression affects chromosome alignment and spindle checkpoint in mouse oocyte meiotic maturation. Cell Cycle 8(20) 3365-3372, 2009.
  65. Schatten H, Sun QY* The role of centrosomes in mammalian fertilization and its significance for ICSI. Molecular Human Reproduction 15:531-538, 2009.
  66. Li M, Schatten H, Sun QY*  Androgen receptor’s destiny in mammalian oocytes: a new hypothesis. Molecular Human Reproduction 15:149-154, 2009.
  67. Sun Y, Kucej M, Fan HY, Yu H, Sun QY, Zou H Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a polynucleotide-dependent manner. Cell 137:123-132, 2009.