Location: Home > Scientists
  Principal Investigators
JIN Wanzhu
Wild Animal Nutrition and Reproduction
+86-10-64806302  / 
Key Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, 1Beichen West Road, Chaoyang District, Beijing 100101, P.R. China
Regulation of Energy Metabolism Group      

Prof. Wanzhu Jin,  Group leader of Wild Animal Nutrition and Reproduction group; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.

1999-2003, Ph.D. United Graduate School of Veterinary Sciences, Gifu University, Japan
1990-1994, BSc. Department of Veterinary Medicine,Yanbian University,Jilin

Professional Experience:
2010-, Professor at Institute of Zoology, Chinese Academy of Sciences
2006-2010, Postdoc,Harvard Medical School
2003-2006, Postdoc Riken Institute, Japan 

Research Interests:
Our major interest is to investigate relationship between energy metabolism and reproduction. Currently, we are focusing on 1, Molecular mechanism of brown adipose tissue differentiation/trans-differentiation; 2, From evolutional and ecological aspect, we apply multiple approaches such as genomic analysis, whole body KO mice, tissue specific KO mice, cellular and molecular techniques to try to understand how energy metabolism and reproduction is tightly connected and affect each other. 

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Zheng Q#, Lin J#, Huang J#, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zhang N, Piao Z, Ye R, Speakman JR, Wang H, Zhou Q, Wang Y*, Jin W*, Zhao J*. Reconstitution of UCP1 Using CRISPR/Cas9 in the White Adipose Tissue of Pigs Decreases Fat Deposition and Improves Thermogenic Capacity. PNAS.2017,114(45): E9474-E9482.
  2. Hu T#, Yuan X, Wei G, Luo H*,Lee HJ*, Jin W*.Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice. Eur J Nutr. 2018.57(1):391-403.
  3. Yilin You#, Xiaoxue Yuan#, Xiaomeng Liu#, Chen Liang, Minghui Meng, Yuanyuan Huang, Xue Han, Jielong Guo, Yu Guo, Chenglong Ren, Qianwen Zhang, Xiangyu Sun,Tingting Ma, Guojie Liu, Wanzhu Jin*,Weidong Huang*and Jicheng Zhan*.Cyanidin-3-glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function .Mol Nutr& Food Res.2017.61(11): 1-13.
  4. Hu T#, Yuan X#, Ye R #, Zhou H, Jun Lin, Zhang C, Hanlin Zhang, Wei G, Meng Dong, Huang Y, Lim W, Liu Q, Lee H, Jin W*. Brown adipose tissue activation by rutin ameliorates polycystic ovary syndrome in rat. JNB.2017.47:21-28.
  5. Rong Wu#, Xiao-meng Liu, Jian-guang Sun, Hong Chen, Jun Ma, Meng Dong, Shengyi Peng, Ji-qiu Wang, Jian-qing Ding, Dong-hao Li , John R Speakman, Guang Ning, Wanzhu Jin*, Zengqiang Yuan*. DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue. Cell Discovery (2017) 3, 16054:1-18.
  6. Lin J#, Cao C#, Tao C#, Ye R, Dong M, Zheng Q, Wang C, Jiang X, Qin G, Yan C,Li K,Speakman J,Wang Y*,Jin W*,Zhao J*. Cold adaptation in pigs depends on UCP 3 in beige adipocytes. JMCB. 2017. 9(5):364-375.
  7. Yuan X#, Wei G#, You Y#, Huang Y, Lee H, Dong M, Lin J, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X, Zhai B, Huang W, Liu S, Xie W, Liu Q, Liu X, Cui C, Li D, Zhan J, Cheng J, Yuan Z, Jin W*. Rutin ameliorates obesity through brown fat activation. the Faseb journal .2017. 31(1):333-345.
  8. Wu R#, Sun JG, Wang JQ, Li B, Liu Q, Ning G, Jin W*, Yuan Z*. c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice. Diabetologia. 2017. 60(5):900-910.
  9. Zhang C#, Weng Y, Shi F, Jin W*.The Engrailed-1 Gene Stimulates Brown Adipogenesis . Stem Cells Int.   2016:7369491.
  10. Liu X#, Wang S#, You Y#, Meng M, Zheng Z, Dong M, Lin J, Zhao Q, Zhang C, Yuan X, Hu T, Liu L, Huang Y, Zhang L, Wang D, Zhan J, Hyuek Jong Lee, Speakman J, Jin W*. Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice. Endocrinology, 2015, 156 (7): 2461-2469.
  11. Jin W, Goldfine A, Boes T, Henry R, Ciaraldi T, et al. (2011) Increased SRF transcriptional activity is a novel signature of insulin resistance in humans and mice. Journal of Clinical Investigation121: 918–929.
  12. Maekawa T,Jin W, Ishii S (2010) ATF2/ATFa regulate BMP induced adipogenesis. Molecular Cellular Biology 30: 613-25.
  13. Jin W, Patti ME (2009) Genetic determinants and molecular pathways in the pathogenesis of diabetes. Clinical Science (Lond). 116: 99-111. Invited Review.
  14. Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T, et al. (2006) Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins. Developmental Cell 10: 461-471. Highlighted in Dev Cell.


  1. Patti ME, Wanzhu Jin, Goldfine A. Inhibiting Serun Response Factor (SRF) to Improve Glycemic Control, filed June 6, 2008, and assigned U.S. Serial Number 61,059,597.
  2. Patti ME, Wanzhu Jin, Goldfine A. Inhibiting Striated Muscle Activator of Rho Signaling (STARS), filed June 4, 2010, and assigned U.S. Serial Number 61351,479.