Location: Home > Scientists
  Principal Investigators
Moshi Song
Pathology and Pathophysiology
+86-10-64809624  / 
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Group of Mitochondrial Disease      

Moshi Song, Ph.D., is a professor in the Institute of Zoology of the Chinese Academy of Sciences. Prof. Song got her master’s degree at Karolinska Institute (Sweden) in 2011 and her Ph.D. at Washington University in St. Louis (USA) in 2015, and later had postdoctoral trainings at Stanford University (USA). Prof. Song has been focusing on the study of mitochondrial regulation of cardiac diseases and aging, with the major findings as follows: 1) elucidated the essential role of mitophagy in developmental cardiac metabolic maturation; 2) revealed the role of of mitochondrial quality control in the maintenance of adult cardiac homeostasis; 3) uncovered multiple molecular mechanisms and therapeutic interventions of cardiovascular aging. In the past five years, she has published 31 papers in top-tier journals including Science, Cell, Cell Metabolism and Circulation Research.

Research Interests:
Mitochondrial regulation of cardiac disease and aging

Awards and Honors:
2019 National Science Fund for Excellent Young Scholars, China
2018 China Heart Congress (CHC) Young Investigator Award at the Basic Science Session, Beijing, China
2018 American Heart Association Postdoctoral Fellowship Award.
2017 Best Poster by EMBO Workshop.
2016 Spencer T. and Ann W. Olin Medical Science Fellow by Washington University in Saint Louis.
2015 Chinese Government Award for Outstanding Self-Financed Students Abroad.
2015 New Investigator Travel Award by American Heart Association Basic Cardiovascular Sciences (BCVS) Scientific Sessions.
2015 Early Career Investigator Travel Award by International Society for Heart Research (ISHR).
2015 Barbara Jakschik Award by Washington University in Saint Louis.
2014 American Heart Association Predoctoral Fellowship Award.
2014 Best Manuscript Awards by Circulation Research.
2014 Best Poster by Gordon Research Seminar.
2013 Keystone Symposia Scholarship.

Professional Activities:
Deputy Secretary General of the Society for Anti-Aging Research in China Association of Gerontology and Geriatrics.
Council member of China Zoological Society.
Committee member of the Society for Aging Cell Research in Chinese Society for Cell Biology. Member of American Heart Association.
Member of International Society for Heart Research (ISHR)

Research Grants:

Selected Publications:
  1. Li H, Wu Z, Liu X, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W, Song M*, Song Eli*, Liu GH* (* corresponding authors). ALKBH1 deficiency leads to loss of homeostasis in human diploid cells. Protein Cell, 2020. In press.
  2. Hu H#, Ji Q#, Song M#, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J (# co-first authors). ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Research, 2020. doi: 10.1093/nar/gkaa425.
  3. Zhang J, Liu GH*, Qu J*, Song M* (* corresponding authors). Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Therapy, 2020. doi: 10.1038/s41434-020-0149-5.
  4. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J* (* corresponding authors). SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell, 2020. In press.
  5. Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Izpisua Belmonte JC , Zhang W, Qu J, Liu GH (# co-first authors). Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell, 180:984-1001, 2020.
  6. Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH, Tang F, Qu J. A single-cell transcriptomic landscape of primate arterial aging. Nature Communications, 11:2202, 2020.
  7. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M&, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, Esteban CR, Chan P &, Qiao J &, Zhou Q &, Izpisua Belmonte JC , Qu J, Tang F, Liu GH (& senior authors). Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell (cover article), 180:585-600, 2020.
  8. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J, Tang F, Liu GH. Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology, 17:e3000201, 2019.
  9. Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M*, Zhang W*, Liu GH*, Qu J* (* corresponding authors). Low-dose quercetin positively regulates mouse healthspan. Protein Cell, 10:770-5, 2019.
  10. Deng L#, Ren R#, Liu Z#, Song M#, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH (# co-first authors). Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nature Communications, 10:3329, 2019.
  11. He X#, Song M#, Qu J, Guo Y, Cao H, Sun R, Liu GH, Shen Y, Major Program Expert Group (# co-first authors). Basic and translational aging research in China: present and future. Protein Cell, 10:476-84, 2019.
  12. Song M, Belmonte JCI, Liu GH. Age-related cardiopathies gene editing. Aging (Albany NY), 11:1327-8, 2019.
  13. Ren X#, Hu B#, Song M#, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH (# co-first authors). Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports, 26:3643-56, 2019.
  14. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W*, Song M*, Qu J*, Liu GH* (* corresponding authors). Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell, 10:649-667, 2019.
  15. Ling C#, Liu Z#, Song M#, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Belmonte JCI, Wang Z, Qu J, Yuan Y, Liu GH (# co-first authors). Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. Protein Cell. 10:249-271, 2019.
  16. Wang Y, Li Y, He C, Gou B, Song M* (* corresponding author). Mitochondrial regulation of cardiac aging. Biochimica et Biophysica Acta - Molecular Basis of Disease, 865:1853-64, 2019.
  17. Geng L#, Liu L#, Zhang W#*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH* (* corresponding authors). Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell, 10:417-35, 2019.
  18. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W&, Song M&, Belmonte JCI&, Qu J, Tang F, Liu GH (& senior authors). FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell (cover article, accompanying editorial), 24:447-61, 2019.
  19. Wang P#, Liu Z#, Zhang X#, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J* (* corresponding authors). CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-kB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell, 9:945-65, 2018.
  20. Wu Z#, Zhang W#, Song M#, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J, Suzuki K, Belmonte JCI, Liu GH. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome (# co-first authors). Protein Cell, 9:333-350, 2018.
  21. Zhang W#, Song M#, Qu J, Liu GH (# co-first authors). Epigenetic modifications in cardiovascular aging and diseases. Circulation Research, 123:773-86, 2018.
  22. Song M, Franco A, Fleischer J, Zhang L, Dorn GW II. Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial aging. Cell Metabolism (cover article), 26:872-83, 2017.
  23. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW II. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metabolism (featured article), 21:273-85, 2015.
  24. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW II (# co-first authors). Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science (accompanying editorial), 350:aad2459, 2015.
  25. Song M#, Matkovich S#, Zhang Y, Hammer D, Dorn GW II (# co-first authors). Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth. Science Signaling (cover article, Podcast interview), 8:ra39, 2015.
  26. Song M, Gong G, Burelle Y, Gustafsson ?B, Kitsis RN, Matkovich SJ, Dorn GW II. Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circulation Research (featured article, accompanying editorial), 117:346-51, 2015.
  27. Song M and Dorn GW II. Mitoconfusion: Non-canonical functioning of dynamism factors in static mitochondria of the heart. Cell Metabolism, 21:195-205, 2015.
  28. Shirihai OS, Song M, Dorn GW II. How mitochondrial dynamism orchestrates mitophagy. Circulation Research, 116:1835-49, 2015.
  29. Dorn GW II, Song M, Walsh K. Functional implications of mitofusin 2-mediated mitochondrial-SR tethering. Journal of Molecular and Cellular Cardiology, 78C:123-8, 2015.
  30. Song M, Chen Y, Gong G, Murphy E, Rabinovitch P, Dorn GW II. Super-suppression of mitochondrial ROS signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circulation Research (cover article, featured article, accompanying editorial), 115:348-53, 2014.
  31. Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW II. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circulation Research, 114:257-65, 2014.