Location: Home > Scientists
  Principal Investigators
Name:
LIU Guanghui
Subject:
Regenerative Medicine
Tel/Fax:
+86-10-64807852  / 
E-mail:
ghliu@ioz.ac.cn
Address:
State Key Laboratory of Membrane Biology, Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, 3A Datun Road, Chaoyang District, Beijing 100101, China
More:
Group of Aging and Regeneration      
Resume:

Biography

1997 - 2002 B.S., Peking University Health Science Center

2002 - 2007 Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2007 - 2009 Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute

2009 - 2012 Research associate, Gene expression laboratory, The Salk Institute for Biological Studies

2012 - Professor, Institute of Biophysics, Chinese Academy of Sciences

2019 - Professor, Institute of Zoology, Chinese Academy of Sciences

Research Interests:

1. Decoding the genetic and epigenetic mechanisms of human aging

Combining primate models, stem cells, gene-editing techniques, single-cell sequencing and multi-omics analyses, we aim to study the genetic and epigenetic basis of human aging and aging-related diseases and explore new strategies for delaying aging (e.g. brain aging and cardiovascular aging) and for the prevention and treatment of aging-related diseases (e.g. neurodegenerative diseases and atherosclerosis) so as to achieve the goal of healthy aging.

2. Stem cell-based disease mechanism research and precision medicine on human diseases

Using patient-derived induced pluripotent stem cells (iPSC) and diseased embryonic stem cells (ESC) created in vitro, combined with directed differentiation and transplantation technologies, we aim to study molecular mechanisms and new targets of human diseases at the genome level, develop stem cell-based drug screening and evaluation systems, evaluate lead compounds that target specific targets of human diseases and promote the clinical and translational applications of stem cell-based technologies.

3. Development and application of new gene-editing methods and gene therapy technologies

On the basis of HDAdV, telHDAdV, TTALE and CRISPR/Cas9 techniques, we aim to develop new methods to safely and efficiently edit the human genome and establish new de-senescence and regenerative strategies via the applications of stem cells and new strategies for gene therapy, thus providing scientific basis for gene repair in rare diseases, genetic enhancement of human stem cells, and intervention of aging-related diseases.

Awards and Honors:

2019, China Youth Science and Technology Award (special prize)

2019, Chief scientist of Science Fund for Creative Research Groups of NSFC

2019, Gu Xiaocheng Lecture Award

2019, Stem Cell Research Innovation Award

2019, The VCANBIO Award for Innovation and Breakthroughs in Life Sciences and Medicine

2019, Wuxi AppTec Life Science and Chemistry Awards

2019, Promega Innovation Award

2018, Tan Jiazhen Prize in Life Sciences Innovation

2017, Second-class Beijing Science and Technology Award (first place)

2017, Shulan Medical Youth Award

2017, Youth Scientist of Chinese Academy of Sciences

2017, CSCB Young Investigator

2017, Gerontology Outstanding Contribution Award

2016, Innovative Award of “the Capital of Ten Scientific and Technological Research and Management Plan”

2016, National Science Fund for Distinguished Young Scholars

2015, Chief scientist of the National Key Research and Development Program (973) of China

2015, Bill and Melinda Gates Foundation Grand Challenges-Young Scientist

2015, CSSCR Stem Cell Young Investigator Award

2013, Bei Shi-Zhang Young Scientist Award in Biophysics

2012, National Science Fund for Excellent Young Scholars

Editorial board

2019-present, Editorial board, Cell Reports (Impact factor 8.1)

2019-present, Editorial board, Aging Cell (Impact factor 7.2)

2019-present, Editorial board, Cell Regeneration 

2018-present, Associate Editor, Stem Cell Research & Therapy (Impact factor 5.1)

2017-present, Editorial board, Cell Stress

2017-present, Editorial board, Cell Proliferation (Impact factor 5.8)

2017-present, Editorial board, Life Science Alliance (Impact factor 2.6)

2015-present, Deputy Editor-in-Chief, Protein & Cell (Impact factor 10.2)

Scientific committee/board

2019, Scientific Council Member of Academy for Health & Lifespan Research (AHLR)

2019, Vice Director, Institute for Stem Cell and Regeneration, CAS

2019, Vice Director, State Key Laboratory of Membrane Biology

2018, President, Chinese Society of Aging Cell Research (CSACR)

2017, Vice president, Chinese Society of Aging Biology (CSAB)

Professional Activities:

Research Grants:

Selected Publications:
  1. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Tang F*, Liu GH*. A Genome-wide CRISPR-Based Screen Identifies KAT7 as a Senescence Driver. Science Translational Medicine. 2021.13, Jan 6;13(575):eabd2655.
  2. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Wang S, He Y, Esteban CR, Huang J, Yu N, Chan P, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of human skin aging. Developmental Cell. 2021. 56(3):383-397 (Cover story)
  3. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021. 31(2):187-205.
  4. Li H, Wei X, Zhou L, Zhang W, Wang C, Guo Y, Li D, Chen J, Liu T, Zhang Y, Ma S, Wang C, Tan F, Xu J, Liu Y, Yuan Y, Chen L, Wang Q, Qu J, Shen Y, Liu S, Fan G, Liu L, Liu X, Hou Y, Liu GH*, Gu Y*, Xu X*. Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis. Protein Cell.  2021. 12(1):57-66.
  5. Aging Atlas Consortium, Zhang W*, Jing Qu*, Bao Y*, Liu GH*. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021. 8;49(D1):D825-D830.
  6. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC*, Jing Qu*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600. (cover story)
  7. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001. 
  8. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2020. 10;1-18.
  9. Li H, Wu Z, Liu X, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W, Song M*, Song E*, Liu GH*. ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells. Protein Cell. 2020. 11(9):688-695.
  10. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870
  11. Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W*, Liu GH*, Long C*, Niu Y*. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein Cell. 2020. 11(11):809-824. (Cover story)
  12. Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Belmonte JCI, Xiao C, Qu J*, Wang H*, Liu GH*, Su W*. A human circulating immune cell landscape in aging and COVID-19. Protein Cell. 2020. 192:111357.
  13. Wang S, Min Z, Ji Q, Geng L, Su Y, Liu Z, Hu H, Wang L, Zhang W, Suzuiki K, Huang Y,Zhang P, Tang T, Qu J*, Yu Y*, Liu GH*, Qiao J*. Rescue of Premature Aging Defects in Cockayne Syndrome Stem Cells by CRISPR/Cas9-Mediated Gene Correction. Protein Cell. 2020. 11(1):1-22.
  14. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J*, Tang F*, Liu GH*. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019. 24(3), 447-461. (cover story) 
  15. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Belmonte J, Chan P, Qu J*, Liu GH*. Stabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis. Nature Communications. 2019.10(1):3329.
  16. Cheng F, Wang S, Song M, Liu Z, Liu P, Chan P, Wang Y, Wang L, Zhang W*, Qu J*, Liu GH*. DJ-1 is Dispensable for Human Stem Cell Homeostasis. Protein Cell. 2019. 10(11):846-853.
  17. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*. Upregulation of FOXD1 by YAP Alleviates Senescence and Osteoarthritis. PLoS Biology. 2019. 17(4):e3000201.
  18. Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Belmonte JC, Wang Z, Qu J*, Yuan Y*, Liu GH*. Modeling CADASIL Vascular Pathologies with Patient-Derived Induced Pluripotent Stem Cells. Protein Cell. 2019. 10(4):249-271.
  19. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Cell Reports. 2019. 26(13):3643-3656.
  20. Geng L, Liu Z, Zhang W*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical Screen Identifies a Geroprotective Role of Quercetin in Premature Aging. Protein Cell. 2019. 10(6):417-435.
  21. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 Deficiency Results in Developmental Retardation in Cynomolgus Monkeys. Nature. 2018. 560(7720):661-665. 
  22. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*. ATF6 Safeguards Organelle Homeostasis and Cellular Aging in Human Mesenchymal Stem Cells. Cell Discovery. 2018. Jan 5;4:2. 
  23. Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH*, Wang L*. Metformin Alleviates Human Cellular Aging by Upregulating the ER Peroxidase GPx7. Aging Cell. 2018.17(4):e12765.
  24. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J*, Suzuki K*, Belmonte JC*, Liu GH*. Differential Stem Cell Aging Kinetics in Hutchinson–Gilford Progeria Syndrome and Werner Syndrome. Protein Cell. 2018. 9(4):333-350. (cover story)
  25. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*, Qu J*, Liu GH*. Visualization of Aging-associated Chromatin Alterations with an Engineered Tale System. Cell Research. 2017. 27(4):483-504. (cover story)
  26. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J*, Tang F*, Liu GH*. Genetic Enhancement in Cultured Human Adult Stem Cells Conferred by a Single Nucleotide Recoding. Cell Research. 2017. 27(9):1178-1181.
  27. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*. CRISPR/Cas9-Mediated Targeted Gene Correction in Amyotrophic Lateral Sclerosis Patient iPSCs. Protein Cell. 2017. 8(5):365-378. (cover story)  
  28. Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH*, Misteli T*, Repression of the Antioxidant NRF2 Pathway in Premature Aging. Cell. 2016. 165(6):1361-1374.
  29. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang F*, Liu GH*. SIRT6 Safeguards Human Mesenchymal Stem Cells From Oxidative Stress by Coactivating NRF2. Cell Research. 2016. 26(2):190-205.
  30. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nu?ez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. In Vivo Genome Editing via CRISPR/Cas9 Mediated Homology-Independent Targeted Integration. Nature. 2016. 540(7631):144-149.
  31. Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC*, Qu J*, Liu GH*. Modeling Xeroderma Pigmentosum Associated Neurological Pathologies with Patients-Derived iPSCs. Protein Cell. 2016.7(3):210-221.
  32. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-507.
  33. Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J*, Zhang W*, Liu GH*. Vitamin C Alleviates Aging Defects in a Stem Cell Model for Werner Syndrome. Protein Cell. 2016. 7(7):478-488. (cover story)
  34. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F*, Liu GH*, Belmonte JC*. A Werner Syndrome Stem Cell Model Unveils Heterochromatin Alterations as a Driver of Human Aging. Science. 2015; 348(6239):1160-1163.
  35. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC. Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell. 2015; 161(3):459-469.
  36. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC, Chen Z, Wang X, Jiang T, Qu J*, Tang F*, Liu GH*. PTEN Deficiency Reprograms Human Neural Stem Cells Towards a Glioblastoma Stem Cell-Like Phenotype. Nature Communications. 2015. 6:10068.
Reviews:
  1. The Aging Epigenome and its Rejuvenation. Nature Review Molecular Cell Biology. 2020. 21(3):137-150.
  2. Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1):22-23. DOI: 10.1016/j.cell.2020.03.026. (Voices)
  3. Single-Cell “OMICS” in Aging: A Young Growing Field. Nature Metabolism. 2020. 2: 293-302.
  4. A Beta-Galactosidase Kiss of Death for Senescent Cells. Cell Research. 2020. 30(7):556-557.
  5. Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene Therapy. 2020. 27(7-8):309-311. 
  6. Protein Quality Control of Cell Stemness. Cell Regeneration. 2020. 12;9(1):22. 
  7. Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328.
  8. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786.
  9. Regulation of Stem Cell Aging by Metabolism and Epigenetic Factors. Cell Metabolism. 2017. 26(3):460-474.