|
|
论文题目: |
Nematode-derived drosomycin-type antifungal peptides provide evidence for plant-to-ecdysozoan horizontal transfer of a disease resistance gene
|
论文题目英文: |
|
作者: |
朱顺义*,高斌
|
论文出处: |
|
年: |
2014
|
卷: |
5 |
期: |
3154 |
页: |
|
联系作者: |
朱顺义 |
发表期刊: |
Nature Communications |
ISSN: |
|
第一作者所在部门: |
|
收录类别: |
|
论文链接: |
http://www.nature.com/ncomms/2014/140117/ncomms4154/full/ncomms4154.html |
影响因子: |
|
摘要: |
Drosomycin-type antifungal peptides (DTAFPs) are key innate immunity components of Drosophila and plants and confer resistance to fungal infection. Here we report the discovery of a multigene family of DTAFPs, comprising of 15 members (termed cremycin-1 to crymycin-15), in the fruit nematode Caenorhabditis remanei. Cremycins share highly similar amino-acid sequences and identical precursor organization to drosomycins. Of the 15 cremycin genes, 10 are found to be transcriptionally active and 6 are upregulated after fungal challenge. Synthetic cremycin-5 is active on filamentous fungi and a series of clinical isolates of human pathogenic yeasts and exhibits low haemolysis and high serum stability. The specific distribution of DTAFPs in a clade of moulting animals (Ecdysozoa), including Arthropoda, Nematoda and Tardigrada, together with the widespread presence in plants but the absence in fungi and protozoans, provides evidence for horizontal transfer of a disease resistance gene between plants and ecdysozoans. |
英文摘要: |
|
外单位作者单位: |
|
|
|
【打印】【关闭】 |
|