| 简历： |
王宪辉,中国科学院动物研究所研究员，行为遗传学研究组组长，博士生导师。2004年中国科学院动物研究所获博士学位，并留所工作，2005-2007年在美国马里兰大学从事博士后研究。研究工作以我国重要的农业昆虫为模式系统，运用基因组学等多学科交叉手段，开展昆虫聚群和社会行为调控机制研究。迄今已在Nature communications, Annual Review of Entomology, PNAS, Science Advances, eLife, PloS Genetics, GigaScience, RNA Biology,Insect Molecular Biology, Journal of Insect Physiology等国内外学术期刊发表论文30多篇。主持国家自然科学基金、973等多项国家级课题。获第十四届中国青年科技奖（2016年），2017年国家自然科学二等奖（排名第二）。现担任中国昆虫学会常务理事，中国昆虫学会青年工作委员会主任委员，昆虫基因组学专业委员会副主任委员，中国动物学会动物行为学专业委员会常务理事，北京昆虫学会理事，昆虫学报、应用昆虫学报期刊编委等学术职务。 |
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| 研究领域： |
主要以我国重要的农业大害虫——飞蝗为研究对象，以其生态适应性为科学问题，开展了三个方面的工作：（1）飞蝗低温适应性机制的研究；（2）飞蝗两型转变分子机制的研究；（3）飞蝗表观遗传学机制的研究。通过这些工作，来探索和揭示基因的表达调控在生物体适应环境中的作用。 |
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| 承担科研项目情况： |
- 中国科学院科技服务网络计划(STS计划)项目, KFJ-STS-ZDTP-028、中国本土授粉熊蜂驯化和优繁的产品化示范 2018/01/01-2019/06/30,200万元、主持
- 国家自然科学基金面上项目，31772531、飞蝗感知促成熟信息素的神经分子机制 2018/01/01-2021/12/31, 61万元、主持。
- 中科院战略性先导科技专项、XDB11010100、信息流外周神经感知机制 2014/07-2019/06、750万、主持。
- 国家自然科学基金面上项目，31472047、乙酰肉碱参与飞蝗两型转变调控的表观遗传机制研究、2015/01-2018/12、88万，主持。
- 国家重点发展基础研究计划（973计划）课题，2012CB114100-2、害虫暴发成灾的行为遗传机理、2012/01-2016/12、100万、在研、子课题主持。
- 国家自然科学基金面上项目，30970407、Hexamerin基因家族在飞蝗型变过程中的功能分析、2010/01-2012/12、33万、已结题、主持。
- 农业部转基因专项重点课题，2009ZX08009-099B、昆虫抗冻蛋白基因的克隆和功能鉴定、2009/01-2012/12、294万、结题、主持。
- 中科院创新课题，2010-Biols-CAS-0304、非编码RNA的鉴定和算法开发、2010/01-2012/12、35万、结题、主持。
- 国家自然科学基金重点项目，30830022、飞蝗两型转变的基因组学研究、2008/01-2012/12、180万、已结题、参加。
- 北京市科委项目，动物与人科普平台建设、2007/01-2008/12、35万、已结题、主持。
- 国家自然科学基金面上项目，30330110、利用OligoDNA微阵列技术研究飞蝗低温适应性的分子机理、2006/01-2008/12、27万、已结题、主持。
- 国家重点发展基础研究计划（973计划），2006CB102000-1、害虫生长发育与生殖调控的分子机制、2006/01-2011/12、57万、已结题、子课题主持。
- 国家科技部863划课题、2003AA222080、飞蝗散居、群居两型转变分子机理的规模化研究、2004/01-2005/12、100万、已结题、参加。
- 国家自然科学基金重点项目，30330110、飞蝗对低温胁迫的适应性机理研究、2003/01-2007/12、115万、已结题、参加。
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| 代表论著： |
- Yang P.C., Hou, L., Wang X.H.*, Kang L.* 2019, Core transcriptional signatures of phase change in the migratory locust. Protein&Cell, DOI: 10.1007/s13238-019-0648-6 (*Co-corresponding author)
- Hou L., Li B.B., Ding D., Kang L.*, Wang X.H.* 2019, CREB-B acts as a key mediator of NPF/NO pathway involved in phase-related locomotor plasticity in locusts. PLoS Genetics, 15(5): e1008176. (*Co-corresponding author)
- Wei, J.N., Shao, W.B., Cao, M.M., Ge, J., Yang, P.C., Chen, L., Wang, X.H.*, Kang, L.* 2019, Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor. Science Advances, DOI: 10.1126/sciadv.aav5495. (*Co-corresponding author)
- Zhou, F., Kang, L.*, Wang, X.H.* 2019,JUMPING Detector: An automated monitoring equipment for the locomotion of jumping insects. Insect Science, DOI: 10.1111/1744-7917.12668. (*Co-corresponding author)
- Chen, D.F., Tang, J.X., Li, B.B., Hou, L., Wang, X.H.*, Kang, L.*, 2018, CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust. BMC Biotechnology, 18:60. (*Co-corresponding author)
- Guo, W., Ren, D.N., Zhao, L.F., Jiang, F., Song, J., Wang, X.H.*, Kang, L.*, 2018, Identification of Odorant-Binding Proteins (OBPs) and Functional Analysis of Phase-Related OBPs in the Migratory Locust. Frontiers in Physiology, doi: 10.3389/fphys.2018.00984. (*Co-corresponding author)
- Li, B.B., Hou, L., Zhu, D., Xu, X.L., An, S.H.*, Wang, X.H.*. 2018 Identification and caste-dependent expression patterns of DNA methylation associated genes in Bombus terrestris. Scientic Reports, 8: 2332. DOI:10.1038/s41598-018-20831-1 (*Co-corresponding author)
- Zhu, J., F. Jiang, X. Wang, P. Yang, Y. Bao, W. Zhao, W. Wang, H. Lu, Q. Wang, N. Cui, J. Li, X. Chen, L. Luo, J. Yu, L. Kang* and F. Cui* (2017). "Genome sequence of the small brown planthopper, Laodelphax striatellus." Gigascience 6(12): 1-12.
- Chen, Z.Z., Liu, L., Liu, S., Cheng, L., Wang, X.H., and Xu, Y*. 2017 Response of Chrysoperla nipponensis (Okamoto)(Neuroptera: Chrysopidae) Under Long and Short Photoperiods. Journal of insect science 17, 35.
- Jiang, F., Liu, Q., Liu, X., Wang, X.H.*, and Kang, L.* 2017 Genomic data from arthropods reveal high conservation but divergent evolutionary pattern of Polycomb/Trithorax group genes in arthropods. Insect science. doi: 10.1111/1744-7917.12558. (*Co-corresponding author)
- Jiang F, Liu Q, Wang Y.L., Zhang J., Wang H.M., Song T.Q., Yang M.L., Wang X.H. *, Kang L.* 2017 Comparative genomic analysis of SET-domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifier in insects. GigaScience, gix031. (*Co-corresponding author)
- Hou, L., Yang, P.C., Jiang, F., Liu, Q., Wang, X.H. *, Kang, L. * 2017. The neuropeptide F/nitric oxide pathway is essential for shaping locomotor plasticity underlying locust phase transition. eLife 10.7554/eLife.22526. (*Co-corresponding author)
- Wei, J.N., Shao, W.B., Wang, X.H., Ge, J., Chen, X.Y., Yu, D., Kang L.* 2017. Composition and emission dynamics of migratory locust volatiles in response to changes in developmental stages and population density.Insect Science 24: 60-72.
- Li, Y., Zhang, J., Chen, D.F., Yang, P.C., Jiang, F., Wang, X.H.*, Kang, L.* 2016. CRISPR/Cas9 in locusts: Successful establishment of an olfactory deficiency line by targeting the mutagenesis of an odorant receptor co-receptor (Orco). Insect Biochemistry and Molecular Biology 79: 27-31. (*Co-corresponding author)
- Chen, B., Wang, X.H., Tu, Z.J., Huang, Y.P. 2016. Leap forward with insect genomics preface. Insect Science 23: 332-334.
- Li, J., Lu, Z.K., He, J., Chen, Q.Q., Wang, X.H., Kang, L., Li, X.D.* 2016. Alternative exon‐encoding regions of Locusta migratoria muscle myosin modulate the pH dependence of ATPase activity. Insect Molecular Biology doi: 10.1111/imb.12254
- Guo, S.Y., Jiang, F., Yang, P.C., Liu, Q., Wang X.H. *, Kang, L. * 2016. Characteristics and expression patterns of histone-modifying enzyme systems in the migratory locust. Insect Biochemistry and Molecular Biology 76: 18-28. (*Co-corresponding author)
- Xu, J. J., Wan, G.J., Hu, D.B., He, J., Chen, F.J., Wang, X.H., Hua, H.X., Pan, W.D.* 2016. Molecular characterization, tissue and developmental expression profiles of cryptochrome genes in wing dimorphic brown planthoppers, Nilaparvata lugens. Insect science doi: 10.1111/1744-7917.12256.
- Wang, Z.F., Yang, P.C., Chen D.F., Jiang, F., Li, Y., Wang, X.H. *, Kang, L. *, 2015 Identification and functional analysis of olfactory receptor family reveal unusual characteristics of the olfactory system in the migratory locust. Cellular and Molecular Life Sciences, 72, 4429-4443. (*Co-corresponding author)
- Hou, L., Jiang, F., Yang, P.C., Wang, X.H.*, Kang, L.*, 2015 Molecular characterization and expression profiles of neuropeptide precursors in the migratory locust. Insect Biochemistry and Molecular Biology, 63, 63-71. (*Co-corresponding author)
- Wang, X.H., Fang, X.D., Yang, P.C., Jiang, X.T., Jiang, F., Zhao, D.J., Li, B.L., Cui, F., Wei, J.N., Ma, C., Wang, Y.D., He, J., Luo, Y., Wang, Z.F., Guo, X.J., Guo, W., Wang, X.S., Zhang, Y., Yang, M.L., Hao, S.G., Chen, B., Ma, Z.Y., Yu, D., Xiong, Z.Q., Zhu, Y.B., Fan, D.D., Han, L.J., Wang, B., Chen, Y.X., Wang, J.W., Yang, L., Zhao, W., Feng, Y., Chen, G.X., Lian, J.M., Li, Q.Y., Huang, Z.Y., Yao, X.M., Lv, N., Zhang, G.J., Li, Y.R., Wang, J., Wang, J., Zhu, B.L., Kang, L.*, 2014 Locust genome sequence provides insight into swarm formation and long-distance flight. Nature Communications 10.1038/ncomms3957.
- Wang, X.H., Kang, L., 2014. Molecular mechanisms of phase change in locusts. Annual Review of Entomology, 59, 225-243.
- Luo, Y., Wang, X.H.*, Yu, D., Chen, B., Kang, L., 2013. Differential responses of migratory locusts to systemic RNA interference via double-stranded RNA injection and feeding. Insect Molecular Biology, 22：574-583. (*The first co-author)
- Jiang, F., Yang, M.L., Guo, W., Wang, X.H., Kang, L., 2012, Large-scale transcriptome analysis of retroelements in the migratory locust, Locusta migratoria. PLoS One, 7: e40532.
- Wu, R., Wu, Z.M., Wang, X.H.*, Yang, P.C., Yu, D., Zhao, C.X., Xu, G.W. and Kang L., 2012. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. Proceedings of the National Academy of Sciences of (USA), 109: 3259-3263. (*The first co-author)
- Luo, Y., Wang, X.H.*, Yu, D., Kang, L., 2012. The SID-1 double-stranded RNA transporter is not required for systemic RNAi in the migratory locust. RNA Biology, 9：1-6. (*The first co-author)
- Wang, H.S., Ma, Z.Y., Cui, F. Wang, X.H., Guo, W., Yang, P.C. and Kang L., 2012. Parental phase status affects the cold hardiness of progeny eggs in locusts. Functional Ecology, 26：379–389.
- Guo, W., Wang, X.H.*, Ma, Z.Y., Xue, L., Han, J.Y., Yu, D., and Kang L., 2011. CSP and takeout genes modulate the switch between attraction and repulsion during behavioral phase change in the migratory locust. PLoS Genetics,7: e1001291, 1-13. (*The first co-author)
- Ma, Z.Y., Guo, W., Guo, X.J., Wang, X.H., Kang L., 2011, Modulation of behavioral phase changes of the migratory locust by the catecholamine metabolic pathway. Proceedings of National Academy of Sciences (USA),108: 3882-3887.
- Zhang, Y., Wang, X.H., and Kang L., 2011. A k-mer scheme to predict piRNAs and characterize locust piRNAs. Bioinformatics, 27: 771–776.
- Guo, W., Wang, X.H.*, Zhao, D.J., Yang, P.C. and Kang L., 2010. Molecular cloning and temporal-spatial expression of I element in gregarious and solitary locusts. Journal of Insect Physiology, 56: 943-948. (*The first co-author)
- Wang, X.H., Qi, X.L., and Kang L., 2010. Geographic differences on accumulation of sugars and polyols in locust eggs in response to cold acclimation. Journal of Insect Physiology, 56: 966-970.
- Baker, R.H., Morgan, J., Wang, X.H., Boore, J.L. and Wilkinson, G.S., 2009. Genomic analysis of a sexually-selected character: EST sequencing and microarray analysis of eye-antennal imaginal discs in the stalk-eyed fly Teleopsis dalmanni (Diopsidae). BMC Genomics, 10: 361.
- Wang, H.S., Wang, X.H.*, Guo, W., Zhang, S.F. and Kang L., 2007. cDNA cloning of heat shock proteins and their expression in the two phases of the migratory locust. Insect Molecular Biology, 16: 207-219. (*The first co-author)
- Qi, X.L., Wang, X.H*. and Kang L., 2007. Influence of soil moisture on egg cold hardiness in the migratory locust Locusta migratoria (Orthoptera:Acridiidae). Physiol. Entomol., 32: 219-224. (*The first co-author)
- Jing, X.H., Wang, X.H. and Kang L., 2005. Chill injury in the eggs of the migratory locust, Locusta migratoria (Orthoptera: Acrididae): the time-temperature relationship with high-temperature interruption. Insect Science, 12: 171-178.
- Wang, X.H., Kang L., 2005. Differences in egg thermotolerance between tropical and temperate populations of the migratory locust Locusta migratoria (Orthoptera: Acridiidae). Journal of Insect Physiology, 51: 1277-1285.
- Wang, X. H. and Kang L., 2003. Rapid cold hardening in young hoppers of the migratory locust Locusta migratoria L. (Orthoptera:Acridiidae). CryoLetters,24: 331-340.
- Wang, X.H., QI X.L., Kang L. 2003. Rapid cold hardening process of insects and its ecological adaptive significance.Prog. Nat. Sci. 13: 641-647.
- 侯丽，詹帅，周欣，李飞，王宪辉* 2017 中国昆虫基因组学的研究进展，应用昆虫学报，54:693-704. （*通讯作者）
- 崔宁宁，宋希明，邹元平，郝树广，许永玉, 王宪辉* 2013 应用差示扫描量热法检测昆虫总蛋白的热滞活性，昆虫学报，56：131-135. （*通讯作者）
- 于芹，安国利，王宪辉*, 2011. 昆虫Takeout蛋白家族的研究进展。应用昆虫学报，48: 404-409. （ *通讯作者）
- 冯云甲，徐洪富，王宪辉*，2012 黄粉虫不同抗冻蛋白基因家族成员的低温应激表达，应用昆虫学报，49：681-685. （*通讯作者）
- 王宪辉, 陈兵, 康乐, 2003. 飞蝗热休克蛋白70cDNA片段的克隆和序列分析. 动物学研究，24：256-259.
- 魏佳宁，王宪辉，孙玉诚，鲁敏，张永军，王桂荣，徐卫华，康乐.2012 害虫的遗传与行为调控，应用昆虫学报，2：299-308.
- 王宪辉, 徐洪富, 许永玉, 刘勇, 周真, 20 甜菜夜蛾雌性生殖系统结构、发育分级及在测报上的应用. 植物保护学报， 30:261-266.
- 王宪辉, 徐洪富, 许永玉, 2001. 昆虫分子生物学的一些研究进展. 山东农业大学学报（自然版）, 1:95-98.
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