论文
论文题目: Characterization of Somatic Mutations in Air Pollution-Related Lung Cancer
论文题目英文:
作者: 余贤军①,#Min-Jun Yang①,周博①,王桂珍①,#Yun-Chao Huang①,吴黎川①,程昕,#Zhe-Sheng Wen,#Jin-Yan Huang,#Yun-Dong Zhang,高晓红,#Gao-Feng Li,#Shui-Wang He,#Zhao-Hui Gu,马亮,#Chun-Ming Pan,#Ping Wang,#Hao-Bin Chen,#Zhi-Peng Hong,王晓璐,毛文静,#Xiao-Long Jin,#Hui Kang,#Shu-Ting Chen,#Yong-Qiang Zhu,#Wen-Yi Gu,刘姿,#Hui Dong,#Lin-Wei Tian,#陈赛娟*,#曹毅*,#王升跃*,周光飚*
论文出处:
年: 2015
卷: DOI: 10.1016/j.ebiom.2015.04.003
期:
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联系作者: #陈赛娟*,#曹毅*,#王升跃*,周光飚*
发表期刊: EBioMedicine
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论文连接 http://www.sciencedirect.com/science/article/pii/S2352396415000973
影响因子:
摘要: Air pollution has been classified as Group 1 carcinogenic to humans, but the underlying tumorigenesis remains unclear. In Xuanwei City of Yunnan Province, the lung cancer incidence is among the highest in China attributed to severe air pollution generated by combustion of smoky coal, providing a unique opportunity to dissect lung carcinogenesis of air pollution. Here we analyzed the somatic mutations of 164 non-small cell lung cancers (NSCLCs) from Xuanwei and control regions (CR) where smoky coal was not used. Whole genome sequencing revealed a mean of 289 somatic exonic mutations per tumor and the frequent C:G → A:T nucleotide substitutions in Xuanwei NSCLCs. Exome sequencing of 2010 genes showed that Xuanwei and CR NSCLCs had a mean of 68 and 22 mutated genes per tumor, respectively (p < 0.0001). We found 167 genes (including TP53, RYR2, KRAS, CACNA1E) which had significantly higher mutation frequencies in Xuanwei than CR patients, and mutations in most genes in Xuanwei NSCLCs differed from those in CR cases. The mutation rates of 70 genes (e.g., RYR2, MYH3, GPR144, CACNA1E) were associated with patients' lifetime benzo(a)pyrene exposure. This study uncovers the mutation spectrum of air pollution-related lung cancers, and provides evidence for pollution exposure–genomic mutation relationship at a large scale.
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