论文
论文题目: N6-methyladenine functions as a potential epigenetic mark in eukaryotes
论文题目英文:
作者: 孙钦秒*,黄守均,王晓娜,朱元祥,陈振平,陈大华*
论文出处:
年: 2015
卷: DOI: 10.1002/bies.201500076
期:
页:
联系作者: 孙钦秒,陈大华
发表期刊: BioEssays
ISSN:
第一作者所在部门:
收录类别:
论文连接 http://onlinelibrary.wiley.com/doi/10.1002/bies.201500076/full
影响因子:
摘要: N6-methyladenine (6mA) is one of the most abundant types of DNA methylation, and plays an important role in bacteria; however, its roles in higher eukaryotes, such as plants, insects, and mammals, have been considered less important. Recent studies highlight that 6mA does indeed occur, and that it plays an important role in eukaryotes, such as worm, fly, and green algae, and thus the regulation of 6mA has emerged as a novel epigenetic mechanism in higher eukaryotes. Despite this intriguing development, a number of important issues regarding its biological roles are yet to be addressed. In this review, we focus on the 5mC and 6mA modifications in terms of their production, distribution, and the erasure of 6mA in higher eukaryotes including mammals. We perform an analysis of the potential functions of 6mA, hence widening understanding of this new epigenetic mark in higher eukaryotes, and suggesting future studies in this field.
英文摘要:
外单位作者单位: