| 论文题目： | Autophagy Regulates Spermatid Differentiation via Degradation of PDLIM1 |
| 论文题目英文： | |
| 作者： | 尚永亮，王红娜，#Peng-Fei Jia，赵海超，刘超，刘卫晓，宋振华，徐志良，#Lin Yang，#Yan-Fang Wang，李卫* |
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| 年： | 2016 |
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| 期： | DOI: 10.1080/15548627.2016.1192750 |
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| 联系作者： | 李卫 |
| 发表期刊： | Autophagy |
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| 论文连接 | http://www.tandfonline.com/doi/full/10.1080/15548627.2016.1192750 |
| 影响因子： | |
| 摘要: | Spermiogenesis is a complex and highly ordered spermatid differentiation process that requires reorganization of cellular structures. We have previously found that Atg7 is required for acrosome biogenesis. Here, we show that autophagy regulates the round and elongating spermatids. Specifically, we found that Atg7 is required for spermatozoa flagella biogenesis and cytoplasm removal during spermiogenesis. Spermatozoa motility of atg7-null mice dropped significantly with some extra-cytoplasm retained on the mature sperm head. These defects are associated with an impairment of the cytoskeleton organization. Functional screening revealed that the negative cytoskeleton organization regulator, PDLIM1 (PDZ and LIM domain 1 [elfin]), needs to be degraded by the autophagy-lysosome-dependent pathway to facilitate the proper organization of the cytoskeleton. Our results thus provide a novel mechanism showing that autophagy regulates cytoskeleton organization mainly via degradation of PDLIM1 to facilitate the differentiation of spermatids. |
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