科研成果
概况介绍
获奖
论文
专著
专利
成果转化
现在位置:首页 > 科研成果 > 论文

论文题目: Essential Role for SUN5 in Anchoring Sperm Head to the Tail
论文题目英文:
作者: 尚永亮①,#朱复希①,王丽娜,欧阳迎春,Ming-Zhe Dong,刘超,赵海超,崔秀宏,马东媛,#Zhi-Guo Zhang,#Xiao-Yu Yang,#Yue-Shuai Guo,刘峰,#Li Yuan,高飞*,#郭雪江*,孙青原*,#曹云霞*,李卫*
论文出处:
年: 2017
卷: 6
期:
页: Article No. e28199
联系作者: 高飞,#郭雪江,孙青原,#曹云霞,李卫
发表期刊: Elife
ISSN:
第一作者所在部门:
收录类别:
论文链接: https://elifesciences.org/articles/28199#downloads
影响因子:
摘要: SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in nuclear dynamics. SUN5 is a new member of the SUN family, with little knowledge regarding its function. Here, we generated Sun5−/− mice and found that male mice were infertile. Most Sun5-null spermatozoa displayed a globozoospermia-like phenotype but they were actually acephalic spermatozoa. Additional studies revealed that SUN5 was located in the neck of the spermatozoa, anchoring sperm head to the tail, and without functional SUN5 the sperm head to tail coupling apparatus was detached from nucleus during spermatid elongation. Finally, we found that healthy heterozygous offspring could be obtained via intracytoplasmic injection of Sun5-mutated sperm heads for both male mice and patients. Our studies reveal the essential role of SUN5 in anchoring sperm head to the tail and provide a promising way to treat this kind of acephalic spermatozoa-associated male infertility.
英文摘要:
外单位作者单位:
   

关闭窗口

返回首页