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论文题目: Membrane Targeting of Inhibitory Smads Through Palmitoylation Controls TGF-β/BMP Signaling
论文题目英文:
作者: 李文卿①,李玮妮①,#邹丽辉①,计山明,李超逸,Ke-Hui Liu,张国强,孙钦秒*,#肖飞*,陈大华*
论文出处:
年: 2017
卷: 114
期: 50
页: 13206-13211
联系作者: 孙钦秒,#肖飞,陈大华
发表期刊: PNAS
ISSN:
第一作者所在部门:
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论文链接: http://www.pnas.org/content/114/50/13206.full
影响因子:
摘要: TGF-β/BMP (bone morphogenetic protein) signaling pathways play conserved roles in controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily targeting the type I receptors for ubiquitination and turnover. However, little is known about how I-Smads access the membrane to execute their functions. Here we show that Dad, the Drosophila I-Smad, associates with the cellular membrane via palmitoylation, thereby targeting the BMP type I receptor for ubiquitination. By performing systematic biochemistry assays, we characterized the specific cysteine (Cys556) essential for Dad palmitoylation and membrane association. Moreover, we demonstrate that dHIP14, a Drosophila palmitoyl acyl-transferase, catalyzes Dad palmitoylation, thereby inhibiting efficient BMP signaling. Thus, our findings uncover a modification of the inhibitory Smads that controls TGF-β/BMP signaling activity.
英文摘要:
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