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论文题目: Histone Deacetylase 1 Plays an Acetylation-Independent Role in Influenza A Virus Replication
论文题目英文:
作者: 陈林①,王承民①,罗静①,苏文,李萌,赵娜,吕文婷,Hamidreza Attaran,Ya-Peng He,#Hua Ding,何宏轩*
论文出处:
年: 2017
卷: 8
期:
页: Article No. 1757
联系作者: 何宏轩
发表期刊: Frontiers in Immunology
ISSN:
第一作者所在部门:
收录类别:
论文链接: https://www.frontiersin.org/articles/10.3389/fimmu.2017.01757/full
影响因子:
摘要: Influenza A viruses (IAVs) take advantage of the host acetylation system for their own benefit. Whether the nucleoprotein (NP) of IAVs undergoes acetylation and the interaction between the NP and the class I histone deacetylases (HDACs) were largely unknown. Here, we showed that the NP protein of IAV interacted with HDAC1, which downregulated the acetylation level of NP. Using mass spectrometry, we identified lysine 103 as an acetylation site of the NP. Compared with wild-type protein, two K103 NP mutants, K103A and K103R, enhanced replication efficiency of the recombinant viruses in vitro. We further demonstrated that HDAC1 facilitated viral replication viatwo paths: promoting the nuclear retention of NP and inhibiting TBK1-IRF3 pathway. Our results lead to a new mechanism for regulating NP acetylation, indicating that HDAC1 may be a possible target for antiviral drugs.
英文摘要:
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