| 论文题目： | Divergent and Parallel Routes of Biochemical Adaptation in High-Altitude Passerine Birds from the Qinghai-Tibet Plateau |
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| 作者： | 朱筱佳①，管玉艳①，#Anthony V. Signore，#Chandrasekhar Natarajan，#Shane G. DuBay，程亚林，韩乃坚，宋刚，屈延华，#Hideaki Moriyama，#Federico G. Hoffmann，#Angela Fago，雷富民*，#Jay F. Storz* |
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| 年： | 2018 |
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| 期： | DOI: 10.1073/pnas.1720487115 |
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| 联系作者： | 雷富民，#Jay F. Storz |
| 发表期刊： | Proceedings of the National Academy of Sciences of the United States of America |
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| 论文连接 | http://www.pnas.org/content/early/2018/02/02/1720487115 |
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| 摘要: | Mountain ranges and highland plateaus in different parts of the world provide an opportunity to investigate the extent to which native species have followed similar or different routes of adaptation to the challenges of life at high altitude. Here we demonstrate that high-altitude songbirds from the Qinghai-Tibet Plateau independently evolved derived increases in hemoglobin–O2 affinity in comparison with their closest lowland relatives in East Asia. In comparisons that also included more distantly related high-altitude avian taxa, site-directed mutagenesis experiments revealed two cases in which convergent increases in hemoglobin–O2 affinity were caused by identical amino acid substitutions at the same sites. However, most adaptive convergence in protein function was attributable to different amino acid substitutions in different species. |
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