科研成果
概况介绍
获奖
论文
专著
专利
成果转化
现在位置:首页 > 科研成果 > 论文

论文题目: Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain
论文题目英文:
作者: 乔慧敏①,李妍昕①,Chao Feng,多曙光,季芬*,焦建伟*
论文出处:
年: 2018
卷: 22
期: 9
页: 2279-2293
联系作者: 季芬,焦建伟
发表期刊: Cell Reports
ISSN:
第一作者所在部门:
收录类别:
论文链接: http://www.cell.com/cell-reports/fulltext/S2211-1247(18)30187-6
影响因子:
摘要: The precise function and role of nucleosome assembly protein 1-like 1 (Nap1l1) in brain development are unclear. Here, we find that Nap1l1 knockdown decreases neural progenitor cell (NPC) proliferation and induces premature neuronal differentiation during cortical development. A similar deficiency in embryonic neurogenesis was observed in Nap1l1 knockout (KO) mice, which were generated using the CRISPR-Cas9 system. RNA sequencing (RNA-seq) analysis indicates that Ras-associated domain family member 10 (RassF10) may be the downstream target of Nap1l1. Furthermore, we found that Nap1l1 regulates RassF10 expression by promoting SETD1A-mediated H3K4 trimethylation at the RassF10 promoter. Nap1l1KO defects may be rescued by RassF10 overexpression, suggesting that Nap1l1 controls NPC differentiation through RassF10. Our findings reveal an essential role for the Nap1l1 histone chaperone in cortical neurogenesis during early embryonic brain development.
英文摘要:
外单位作者单位:
   

关闭窗口

返回首页