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论文题目: Dnmt2 Mediates Intergenerational Transmission of Paternally Acquired Metabolic Disorders Through Sperm Small Non-Coding RNAs
论文题目英文:
作者: 张云芳①,#张旭东①,#侍骏超①,#Francesca Tuorto①,李鑫①,刘玉胜,#Reinhard Liebers,张力文,曲永存,钱静静,#Maya Pahima,#Ying Liu,#Meng-Hong Yan,曹忠红,雷晓华,曹宇静,#彭洪英,#Shi-Chao Liu,#Yue Wang,#Hui-Li Zheng,#Rebekah Woolsey,#David Quilici,#翟琦巍,李磊,#Tong Zhou,#Wei Yan,#Frank Lyko,张莹*,周琪*,段恩奎*,#陈琦*
论文出处:
年: 2018
卷: 20
期: 5
页: 535-540
联系作者: 张莹,周琪,段恩奎,#陈琦
发表期刊: Nature Cell Biology
ISSN:
第一作者所在部门:
收录类别:
论文链接: https://www.nature.com/articles/s41556-018-0087-2
影响因子:
摘要: The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has opened the possibility that sperm may function by delivering additional paternal information aside from solely providing the DNA1. Increasing evidence now suggests that sperm small non-coding RNAs (sncRNAs) can mediate intergenerational transmission of paternally acquired phenotypes, including mental stress2,3 and metabolic disorders4,5,6. How sperm sncRNAs encode paternal information remains unclear, but the mechanism may involve RNA modifications. Here we show that deletion of a mouse tRNA methyltransferase, DNMT2, abolished sperm sncRNA-mediated transmission of high-fat-diet-induced metabolic disorders to offspring. Dnmt2 deletion prevented the elevation of RNA modifications (m5C, m2G) in sperm 30–40?nt RNA fractions that are induced by a high-fat diet. Also, Dnmt2 deletion altered the sperm small RNA expression profile, including levels of tRNA-derived small RNAs and rRNA-derived small RNAs, which might be essential in composing a sperm RNA ‘coding signature’ that is needed for paternal epigenetic memory. Finally, we show that Dnmt2-mediated m5C contributes to the secondary structure and biological properties of sncRNAs, implicating sperm RNA modifications as an additional layer of paternal hereditary information.
英文摘要:
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