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论文题目: Genome-Wide Identification of Transcription Factors That Are Critical to Non-Small Cell Lung Cancer
论文题目英文:
作者: 张大林①,曲丽威①,马亮①,#Yong-Chun Zhou,王桂珍,赵新春,张晨,张燕飞,王敏,#Mei-Ying Zhang,Hong Yu,孙贝贝,高三慧,程昕,#Ming-Zhou Guo,#Yun-Chao Huang,周光飚*
论文出处:
年: 2018
卷: 434
期:
页: 132-143
联系作者: 周光飚
发表期刊: Cancer Letters
ISSN:
第一作者所在部门:
收录类别:
论文链接: https://www.sciencedirect.com/science/article/pii/S0304383518304786?via%3Dihub
影响因子:
摘要: To systematically unveil transcription factors (TFs) that are critical to lung carcinogenesis, here we conducted a genome-wide lethality screening in non-small cell lung cancer(NSCLC) cells and reported that among the 1530?TFs tested, 21 genes were required for NSCLC cell proliferation and were negatively or positively associated with overall survival (OS) of patients with NSCLC. These included 11 potential tumor suppressing genes (AFF3AhRARCBFA2T3CHD4KANK2NR3C2PTENPRDM16RB1, and STK11) and 10 potential oncogenic TFs (BARX1DLX6ELF3EN1ETV1FOXE1HOXB7IRX4IRX5, and SALL1). The expression levels of IRX5 were positively associated with OS of smoker and inversely associated with OS of non-smoker patients with lung adenocarcinoma. We showed that tobacco carcinogen benzo(a)pyrene (BaP) induced upregulation of IRX5 in lung epithelial cells, and Cyclin D1 was a downstream target of IRX5. Furthermore, silencing of IRX5 by lentivirus mediated transfection of short hairpin RNA significantly inhibited tumor growth in nude mice. These results indicate that tobacco smoke can modulate TFs to facilitate lung carcinogenesis, and inhibition of IRX5 may have therapeutic potentials in NSCLCs.
英文摘要:
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