| 论文题目： | Controllable assembly of skeletal muscle-like bundles through 3D bioprinting |
| 论文题目英文： | |
| 作者： | Tingting Fan, Shuo Wang, Zongmin Jiang, Shen Ji, Wenhua Cao, Wenli Liu, Yun Ji, Yujing Li，Ng Shyh-Chang, and Qi Gu |
| 论文出处： | |
| 年： | 2021 |
| 卷： | 14 |
| 期： | 1 |
| 页： | |
| 联系作者： | 顾奇 |
| 发表期刊： | Biofabrication |
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| 论文连接 | http://iopscience-iop-org-s.webvpn.ioz.ac.cn/article/10.1088/1758-5090/ac3aca |
| 影响因子： | 11.061 |
| 摘要: | 3D printing is an effective technology for recreating skeletal muscle tissue in vitro. To achieve clinical skeletal muscle injury repair, relatively large volumes of highly aligned skeletal muscle cells are required; obtaining these is still a challenge. It is currently unclear how individual skeletal muscle cells and their neighbouring components co-ordinate to establish anisotropic architectures in highly homogeneous orientations. Here, we demonstrated a 3D printing strategy followed by sequential culture processes to engineer skeletal muscle tissue. The effects of confined printing on the skeletal muscle during maturation, which impacted the myotube alignment, myogenic gene expression, and mechanical forces, were observed. Our findings demonstrate the dynamic changes of skeletal muscle tissue during in vitro 3D construction and reveal the role of physical factors in the orientation and maturity of muscle fibres. |
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