| 论文题目： | Targeting stemness of cancer stem cells to fight colorectal cancers |
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| 作者： | Du, Lei; Cheng, Qi; Zheng, Hao; Liu, Jinming; Liu, Lei; Chen, Quan |
| 论文出处： | |
| 年： | 2022 |
| 卷： | 82 |
| 期： | |
| 页： | 150-161 |
| 联系作者： | 杜蕾 |
| 发表期刊： | Seminars in Cancer Biology |
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| 论文连接 | https://www.sciencedirect.com/science/article/pii/S1044579X21000419?via%3Dihub |
| 影响因子： | 17.012 |
| 摘要: | Cancer initiating/ stem cells (CSCs) undergo self-renewal and differentiation that contributes to tumor initiation, recurrence and metastasis in colorectal cancer (CRC). Targeting of colorectal cancer stem cells (CCSCs) holds significant promise in eradicating cancer cells and ultimately curing patients with cancer. In this review, we will introduce the current progress of CCSC studies, including the specific surface markers of CCSCs, the intrinsic signaling pathways that regulate the stemness and differentiation characteristics of CCSCs, and the tumor organoid model for CCSC research. We will focus on how these studies will lead to the progress in targeting specific surface markers or signaling pathways on CCSCs by monoclonal antibodies, or by natural or synthetic compounds, or by immunotherapy. As CSCs are highly heterogeneous and plastic, we suggest that combinatory approaches that target the stemness network may represent an important strategy for eradicating cancers. |
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