研究队伍
院士专家
青年千人
百人计划
杰出青年
研究员
副研究员
人才招聘
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姓  名:
王海滨
学  科:
发育生物学
电话/传真:
+86-10-64807868 / 
电子邮件:
hbwang@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100101
更多信息:
胚胎着床生理学研究组     
简历:

  王海滨,男,1974年9月出生于浙江省义乌市,博士,研究员,博士生导师;中国科学院动物研究所胚胎着床生理学研究组组长。
  “百人计划”引进海外杰出人才,国家杰出青年基金获得者,国家重大研究计划首席科学家。2000-2001年作为短期交换留学生在日本东京农工大农学部田谷一善先生研究室从事合作研究。2001年毕业于中国农业大学,获生理学理学博士学位。2001-2004年在美国堪萨斯大学医学中心和范德堡大学医学中心SK Dey 先生研究室进行博士后训练,曾获 Lalor Foundation 博士后基金资助。2004-2007年在范德堡大学医学中心儿科系先后担任研究助理教授和助理教授。目前主要从事早期胚胎发育、着床和胎盘发生的分子机制研究,相关研究工作以第一作者或通讯作者分别发表在 Nat Med, J Clin Invest, PLoS Biology, Cell Death Differ, Cell Res, PNAS、Development, JBC 等杂志上,已发表SCI论文80多篇,2013年SCI论文他引率2000多次,并于2006年、2010年、2012年分别受邀为 Nat Rev Genet, Endocrine Rev, J Clin Invest, Mol Aspect Med 等杂志撰写特邀综述。王海滨博士多次受邀参加生殖生物学Keystone Symposia并做大会报告,目前担任担任剑桥大学CTR的 Scientific Advisory Board, Biol Reprod, PLoS ONE 等杂志编委会委员。

研究领域:
社会任职:
  • 美国生殖生物学学会(Society for the Study of Reproduction)会员(2001-)
  • 美国内分泌学会(Endocrine Society)会员(2004-)
  • 美国生殖免疫学会(American Society of Reproductive Immunology)会员(2010-)
  • Am J Reprod Immunol杂志编委会委员(2010-)
  • PLoS ONE杂志编委会委员(2010-)
  • Reprod Med Biol杂志编委会委员(2011-)
  • Development & Reproduction杂志编委会委员(2011-)
  • Biol Reprod杂志编委会委员(2012-)
  • 剑桥大学CTR的Scientific Advisory Board(2014-)
  • 中国生理学会常务理事(2014-)
  • 中国动物学会副秘书长(2014-)
  • Invited Guess Editor, Molecular Aspects of Medicine. 2013年特刊:Regulation of Early Pregnancy
  • Invited Guess Editor, International Journal of Endocrinology. 2013年特刊:Endocannabinoids and Reproductio、
  此外,是领域内许多国际刊物,如Nat Med、JCI, JAMA、JBC, Mol Endocrinol, Endocrinology, Biol Reprod, Reproduction, Hum Reprod, Mol Hum Reprod, Fertil Steril, PLoS ONE, BMC Genomics, Placenta等的ad hoc审稿。
获奖及荣誉:
  • Lalor博士后基金
  • Solvay/Joseph Mortola研究奖,由美国妇科研究学会(the Society for Gynecologic Investigation, SGI)颁发,2005年度唯一获奖人
  • “百人计划”引进国外人才(2008-2012年)
  • 国家杰出青年基金获得者(2008年)
  • 973首席科学家(2011年)
  • 中国科学院青年科学家奖(2011年)
  • 第十三届中国青年科技奖(2013年)
  • 中国科学院“优秀百人”(2013年)
  • 中国科学院朱李月华教师奖(2013年)
承担科研项目情况:
  • 基金委重点项目-母-胎互作微环境决定妊娠结局的分子基础(81130009),2012-2016
  • 基金委重点项目-胚胎着床的表观遗传调控机制(81330017),2014-2018
  • 基金委重大项目-母-胎界面微环境训导母-胎免疫耐受的分子机制及其异常调控的致病机制(81490744),2015-2019
  • 基金委面上项目-Notch信号通路在胚胎植入和蜕膜发育过程中的作用机制研究(31471106),2014-2018
国际学术会议主席和特邀大会报告:
  • Invited speaker, Keystone Symposia (Reproduction: Advances and Challenges), Santa Fe, New Mexico, USA, February 20-25, 2007.
  • Invited speaker, Keystone Symposia (Reproduction: Frontiers in Reproductive Biology and Regulation of Fertility), Santa Fe, New Mexico, USA, February 1-6, 2009.
  • Co-chair (Enkui Duan, Haibin Wang, Sudhansu K. Dey and Bruce Murphy), SKLRB Symposia on Frontiers in Periimplantation Biology, Beijing, China May 8-12, 2010.
  • Nature Conference: The Herrenhausen Symposium on Reproductive Biology, Germany, , October 4-7, 2011.
  • Plenary speaker, the 2nd World Congress on Reproductive Biology (WCRB), Cairns, Queensland, Australia, October 9-12, 2011.
  • Co-chair (Enkui Duan, Haibin Wang, Susan J. Fisher and Sudhansu K. Dey), SKLRB Symposia on Frontiers in Reproductive Biology, Beijing, China, May 6-11, 2012.
  • Invited speaker, The 61st NIBB Conference "Cellular Community in Mammalian Embryogenesis", Okazaki,Japan, July 10-12, 2013.
  • Invited speaker,The 47th Japanese Society of Developmental Biologists (JSDB), Nagoya Japan,May 27 – 30, 2014.
  • Invited speaker,2015 CTR Annual Trophoblast meeting and the CTR’s Scientific Advisory Board (SAB), July 11- 16,2015.
代表论著:
  1. Tu Z, Wang Q, Cui T, Wang J , Ran H , Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S, Wu X and Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 23(1):169-81,2016.
  2. Wu W, Kong S, Wang B, Chen Y, Wang H*. Spatiotemporal expression of endogenous opioid processing enzymes in mouse uterus at periimplantation. Cell Tissue Res.  363(2):555-65,2016.
  3. Jiang Y, Liao Y, He H, Xin Q, Tu Z, Kong S, Cui T, Wang B, Quan S, Li B, Zhang S, Wang H*. FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization. Sci Rep. 5: 13735, 2015.
  4. Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H*, Lu Z. Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 5:12982, 2015
  5. He H, Kong S, Liu F, Zhang S, Jiang Y, Liao Y, Jiang Y, Li Q, Wang B, Zhou Z, Wang H*, Huo R. Rbbp7 Is Required for Uterine Stromal Decidualization in Mice. Biol Reprod.  93 (1) 13, 1-11, 2015.
  6. Liao Y, Jiang Y, He H, Ni H, Tu Z, Zhang S, Wang B, Lou J, Quan S, Wang H*. NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization. Hum Reprod. 30(7):1665-76, 2015.
  7. Tang X, Chen Y, Ran H, Jiang Y, He B, Wang B, Kong S, Wang H*. Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice. Biol Reprod. 92(5):0,1-9, 2015.
  8. Chen Y, Kong S, Tang X, Fu Y, Wang B, Zhang S, Wang H*.Preimplantation mouse embryo is a target for opioid ligand-receptor signaling. Biol Reprod. 91(1):4, 1–9,2014.
  9. Tu Z,  Ran H, Zhang S, Xia G, Wang B , Wang H*. Molecular Determinants of Uterine Receptivity.Int. J. Dev. Biol. 58: 147-154 ,2014.
  10. Fu Z, Wang B, Wang S, Wu W, Wang Q,  Jin W, Duan E, Wang H, Wang Y, Li, L, Wang F, Gao S, Wang H*. Integral  Proteomic Analysis of Blastocysts Reveals Key Molecular Machinery Governing Embryonic Diapause and Reactivation for Implantation. Biol Reprod. 90(3):52, 1–11,2014.
  11. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J,John P Lydon, Francesco DeMayo, Warren S. Pear, Hua H, Lin H, Li L, Wang H, Wang Y, Li B, Chen Q, Duan E, Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res.24(8):925-942,2014.
  12. Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A, Wang H*. Wnt6 is essential for stromal cell proliferation during decidualization in mice. Biol Reprod. 88 (1):1-9,2013.
  13. Fu Z, Chen Y, Wu W, Wang S, Wang W, Wang B, Wang H*. Molecular and cellular aspects of blastocyst dormancy and reactivation for implantation. J Stem Cells. 2013;8(2):59-77.
  14. Lu J, Zhang S, Nakano N, Simmons DG, Wang S, Wang Q, Kong S, Shen L, Wang W, Wang B, Wang HM, Wang YL, van Es JH, Clevers H, Leone G, Cross JC, Wang H*. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biology. 11(4), e1001536,2013.
  15. Zhang S, Lin H, Kong S, Wang S, Wang H, Wang H*, Armant DR* (Co-correspondence)..Physiological and molecular determinants of embryo implantation. Mol Aspects Med. 34,939-980,2013.
  16. Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A, Wang H*. Wnt6 is essential for stromal cell proliferation during decidualization in mice. Biol Reprod. 88(1):5, 2013
  17. Zhang S, Kong S, Lu J, Wang Q, Chen Y, Wang W, Wang B, Wang H*. Deciphering the molecular basis of uterine receptivity. Mol Reprod Dev. 80(1):8-21, 2013
  18. Kong S, Zhang S, Chen Y, Wang W, Wang B, Chen Q, Duan E*, Wang H*. Determinants of uterine aging: lessons from rodent models. Sci China Life Sci. 55(8): 687-93, 2012
  19. Lim H & Wang H* (Co-correspondence). Uterine disorders and pregnancy complications: insights from mouse models. J CIin Invest. 120(4), 1004-15, 2010
  20. Chen Q, Zhang Y, Lu J, Wang Q, Wang S, Cao Y, Wang H*, Duan E* (Co-correspondence). Embryo-uterine cross-talk during implantation: The role of Wnt signaling. Mol Hum Reprod. 15(4):215-21, 2009
  21. Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK,Kuo CJ, and Wang H* (*Correspondence). Inactivation of Nuclear Wnt-β-Catenin Signaling Limits Blastocyst Competency for Implantation. Development. 135(4): 717-727, 2008
  22. Xie H*, Wang H* (equal contribution), Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK and Dey SK. Heparin-binding EGF-like growth factor serves as a molecular link between the blastocyst and uterus during implantation. PNAS. 104(46): 18315-20, 2007
  23. Wang H*, Xie H* (equal contribution), Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN and Dey SK. Stage-specific integration of maternal and embryonic PPARδ signaling is critical to pregnancy success. J Biol Chem. 282(52): 37770-37782, 2007
  24. Wang H*, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF and Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events. J CIin Invest. 116 (8): 2122-2131, 2006
  25. Wang H*, Dey SK and Maccarrone M. Jekyll and Hyde: Two faces of cannabinoid signaling in male and female fertility. Endocr Rev. 27 (5): 427-448, 2006
  26. Wang H* and Dey SK. Roadmap to embryo implantation: Clues from mouse models. Nat Rev Genet. 7 (3): 185-199, 2006
  27. Wang H*, Tranguch S* (equal author), Xie H, Hanley G, Das SK, Dey SK. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus. PNAS. 102 (28): 9960-9965, 2005
  28. Guo Y*, Wang H* (equal author), Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HH, Das SK, Dey SK. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem. 280 (25): 23429-23432, 2004
  29. Wang H*, Ma W, Tejada L, Zhang H, Morrow JD, Das SK, and Dey SK. Rescue of female infertility from the loss of Cyclooxygenase-2 by compensatory upregulation of Cyclooxygenase-1 is a function of genetic make-up. J Biol Chem. 279(11): 10649-10658, 2004
  30. Wang H*, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN and Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med.10(10): 1074-1080, 2004
  31. Wang H*, Matsumoto H, Guo Y, Paria BC, Roberts RL, and Dey SK. Differential G-Protein coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. PNAS. 100(25): 14914-14919, 2003
写给考生的话:
  “A career in science is a journey of wonder and discovery. To succeed in science requires curiosity, perseverance, a good dose of luck, and wise guidance from those who have taken the journey ahead of you—— Janet Rossant