姓  名: 韩春生
学  科: 发育生物学
电话/传真: +86-10-64807105 / 
电子邮件: hancs@ioz.ac.cn
通讯地址: 北京市朝阳区大屯路甲3号
中国科学院动物研究所西区 干细胞与生殖生物学国家重点实验室 100101
更多信息: 精原干细胞研究组     

简历介绍:

  韩春生,博士,研究员,博士生导师;中国科学院动物研究所精原干细胞研究组组长。科技部战略性国际科技创新合作重点专项负责人。长期在中国科学院研究生院主讲“生物信息学应用”课程,多次获得优秀课程奖,并获得“中国科学院朱李月华优秀教师奖”。

  1990年复旦大学生物工程系遗传工程专业本科毕业;1993年获生殖生物学国家重点实验室生理学硕士;2000年获美国密苏里大学生物化学系博士学位;2000年至2003年任美国Lexicon Genetics & Pharmaceuticals 公司高级生物信息科学家。归国前曾从事胚胎植入、干扰素信号通路、药物研发等领域的研究。目前主要从事不育治疗新技术的研发,包括两个方向:1. 生殖细胞形成、发育、减数分裂;2. 精原干细胞增殖、分化、重编程。曾承担国家自然科学基金、科技部重大研究计划、“973”等项目的研究课题。作为第一或通讯作者在 Science AdvancesNature Communications、Nucleic Acid Research、Cell Research、EMBO reports, Molecular and Cellular Proteomics、Development、RNA、Stem Cell Reports等期刊发表SCI论文70余篇。已培养博士毕业生19人、硕士生8人、博士后3人。目前在读博士生5人、硕士生3人、博士后2人。

研究领域:

社会任职:

获奖及荣誉:

承担科研项目情况:

  1. 科技部重点研发计划:“计划生命孕育关键环节的分子机制研究“,2019/08 ~ 2023/07;
  2. 科技部重点计划子课题:“多能干细胞向生殖细胞分化模型及调控机制”,2012/01 ~ 2016/12;
  3. 科技部重大计划子课题:“原始生殖细胞特化和定向迁移”,2013/01 ~ 2017/12;
  4. 自然科学基金面上项目:

  ---“BEND2在小鼠生精细胞减数分裂中的分子机制”,2020/01-2023/12;

  ---“利用miRNAs诱导小鼠iPS细胞形成精原干细胞样细胞”,2018/01-2021/12;

  ---“转录因子RFX2调控小鼠精子细胞发育基因转录及表观遗传状态的机理”,2015/01-2018/12;

  ---“小鼠中来源于mRNA的piRNA的生成机理研究”,2013/01 ~ 2016/12;

代表论著:

  1. Ma, L., Xie, D., Luo, M., Lin, X., Nie, H., Chen, J., Gao, C., Duo, S., and Han, C. (2022) Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis. Science Advances, 8(21):eabn1606.
  2. Chen, J., Gao, C., Luo, M., Zheng, C., Lin, X., Ning, Y., Ma, L., He, W., Xie, D., Liu, K., Hong, K., Han, C. (2022) MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage. EMBO Reports, 17;e54298.
  3. Chen, J., Gao, C., Lin, X., Ning, Y., He, W., Zheng, C., Zhang, D., Yan, L., Jiang, B., Zhao, Y., Hossen, MA., Han, C. (2021) The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis. Development, 148(24)
  4. Zheng, C., Ouyang, YC., Jiang, B., Lin, X., Chen, J., Dong, MZ., Zhuang, X., Yuan, S., Sun, QY., Han C. (2019) Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice. Biology of Reproduction, 100(6)
  5. Zhang, D., Xie, D., Lin, X., Ma, L., Chen, J., Wang, Y., Duo, S., Feng, Y., Zheng, C., Jiang, B., Ning, Y., Han, C.(2018) The transcription factor SOX30 is a key regulator of mouse spermiogenesis. Development,145. doi: 10.1242/dev.164723.
  6. Feng, Y., Ning, Y., Lin, X., Zhang, D., Liao, S., Zheng, C., Chen J., Wang Y., Ma L., Xie D., Han C.(2018) Reprogramming p53-Deficient Germline Stem Cells Into Pluripotent State by Nanog. Stem Cells Dev, 27:692-703.
  7. Hu, X., Shen, B., Liao, S., Ning, Y., Ma, L., Chen, J., Lin, X., Zhang, D., Li, Z., Zheng, C., Feng, Y., Huang, X., Han C.(2017) Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint. Cell Death Di, 8:e2910.
  8. Chen, J., Cai, T., Zheng, C., Lin, X., Wang, G., Liao, S., Wang, X., Gan, H., Zhang, D., Hu, X., Wang, S., Li, Z., Feng, Y., Yang, F., and Han, C. (2017) MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins, Nucleic Acids Res. 45(7):4142-4157.
  9. Tu, Z., Bayazit, M. B., Liu, H., Zhang, J., Busayavalasa, K., Risal, S., Shao, J., Satyanarayana, A., Coppola, V., Tessarollo, L., Singh, M., Zheng, C., Han, C., Chen, Z., Kaldis, P., Gustafsson, J. A., and Liu, K. (2017) Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation, Proc Natl Acad Sci U S A, 114:592-597.
  10. Chen, M., Zhang, L., Cui, X., Lin, X., Li, Y., Wang, Y., Wang, Y., Qin, Y., Chen, D., Han, C., Zhou, B., Huff, V., and Gao, F. (2017) Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Development 144, 44-53.
  11. Wang, S., Wang, X., Ma, L., Lin, X., Zhang, D., Li, Z., Wu, Y., Zheng, C., Feng, X., Liao, S., Feng, Y., Chen, J., Hu, X., Wang, M., and Han, C. (2016) Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes, Stem cell reports 7, 80-94.
  12. Lin, X., Han, M., Cheng, L., Chen, J., Zhang, Z., Shen, T., Wang, M., Wen, B., Ni, T., and Han, C. (2016) Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells, RNA biology 13, 1011-1024.
  13. Wu, Y., Hu, X., Li, Z., Wang, M., Li, S., Wang, X., Lin, X., Liao, S., Zhang, Z., Feng, X., Wang, S., Cui, X., Wang, Y., Gao, F., Hess, R. A., and Han, C. (2016) Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis, Scientific reports 6, 20435.
  14. Yang, Y., Feng, Y., Feng, X., Liao, S., Wang, X., Gan, H., Wang, L., Lin, X., and Han, C. (2016) BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia, Stem cells international 2016, 9536192.
  15. Xue, Y., Lameijer, E. W., Ye, K., Zhang, K., Chang, S., Wang, X., Wu, J., Gao, G., Zhao, F., Li, J., Han, C., Xu, S., Xiao, J., Yang, X., Ying, X., Zhang, X., Chen, W. H., Liu, Y., Zhang, Z., Huang, K., and Yu, J. (2016) Precision Medicine: What Challenges Are We Facing?, Genomics, proteomics & bioinformatics 14, 253-261.
  16. Gao, Y., Bai, X., Zhang, D., Han, C., Yuan, J., Liu, W., Cao, X., Chen, Z., Shangguan, F., Zhu, Z., Gao, F., and Qin, Y. (2016) Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis, Nature structural & molecular biology 23, 441-449.
  17. #Zhu, L., #Han, C. S., Cao, Z. L., Wang, Z. B., Han, R. G., Wang, B., and Sun, Q. Y. (2015) Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients, Gynecologic and obstetric investigation 80, 179-186.
  18. Wang S.,Wang Xx.,Wu Yj., and *Han, C. (2015) , IGF-1R Signaling Is Essential for the Proliferation of Cultured Mouse Spermatogonial Stem Cells by Promoting the G2/M Progression of the Cell Cycle,Stem Cells and Development 24,471-483
  19. *Han, C. (2014) , Which one is the real matchmaker for the pair?,Asian Journal of Andrology 16,667-668.
  20. Li, Y., Wang, X., Feng, X., Liao, S., Zhang, D., Cui, X., Gao, F., and *Han, C. (2014) Generation of male germ cells from mouse induced pluripotent stem cells in vitro, Stem Cell Res 12, 517-530.
  21. Gan, H., Wen, L., Liao, S., Lin, X., Ma, T., Liu, J., Song, C.-x., Wang, M., He, C., *Han, C., and *Tang, F. (2013) Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis,Nature Communications 4, 1995.
  22. Wang, F., Yang, Y., Lin, X., Wang, J. Q., Wu, Y. S., Xie, W., Wang, D., Zhu, S., Liao, Y. Q., Sun, Q., Yang, Y. G., *Guo, C., *Han, C., and *Tang, T. S. (2013) Genome-wide Loss of 5-hmC is a Novel Epigenetic Feature of Huntington's Disease, Human Molecular Genetics 22, 3641-3653.
  23. Wu, Y., Liao, S., Wang, X., Wang, S., Wang, M., and Han, C.* (2013) HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm, FEBS Letters (10.1016/j.febslet.2013.04.049).
  24. Shi, Y., Zhuang, X., Xu, B., Hua, J., Liao, S., Shi, Q., Cooke, H. J., Han, C.* (2013) SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60, Gene(10.1016/j.gene.2013.06.033)
  25. Gan, H., Cai, T., Lin, X., Wu, Y., Wang, X., Yang, F., and Han, C.* (2013) Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis, Mol Cell Proteomics 12, 1144-1157.
  26. Hou, X., Zhang, W., Xiao, Z., Gan, H., Lin, X., Liao, S., and Han, C.* (2012) Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis, BMC Genomics 13, 495.
  27. Zhang, Y., Wang, S., Wang, X., Liao, S., Wu, Y., and Han, C.* (2012) Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells, Cell Research 22, 773-776.
  28. Gan, H., Lin, X., Zhang, Z., Zhang, W., Liao, S., Wang, L., and Han, C.* (2011) piRNA profiling during specific stages of mouse spermatogenesis, RNA 17, 1191-1203.
  29. Zhuang, X. J., Hou, X. J., Liao, S. Y., Wang, X. X., Cooke, H. J., Zhang, M., and Han, C.* (2011) SLXL1, a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice, PLoS One 6, e20866.
  30. Shi, Y. Q., Liao, S. Y., Zhuang, X. J., and Han, C. S.* (2011) Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37, Gene 485, 153-159.
  31. Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas, The Journal of biological chemistry 286, 28520-28532.
  32. Liu, H., Wang, B., and Han, C.* (2011) Meta-analysis of genome-wide and replication association studies on prostate cancer, The Prostate 71, 209-224.
  33. Yang, Y., and Han, C.* (2010) GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway, BMC cell biology 11, 78.
  34. Shi, Y. Q., Li, Y. C., Hu, X. Q., Liu, T., Liao, S. Y., Guo, J., Huang, L., Hu, Z. Y., Tang, A. Y., Lee, K. F., Yeung, W. S., Han, C. S.*, and Liu, Y. X. (2009) Male germ cell-specific protein Trs4 binds to multiple proteins, BBRC 388, 583-588.
  35. Nian, H., Zhang, W., Shi, H., Zhao, Q., Xie, Q., Liao, S., Zhang, Y., Zhang, Z., Wang, C., and Han, C.* (2008) Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase, Cell research 18, 800-802.
  36. Zhang, K., Shang, Y., Liao, S., Zhang, W., Nian, H., Liu, Y., Chen, Q., and Han, C.* (2007) Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis, BBRC 360, 327-332.
  37. Nian, H., Fan, C., Liao, S., Shi, Y., Zhang, K., Liu, Y., and Han, C.* (2007) RNF151, a testis-specific RING finger protein, interacts with dysbindin, Archives of biochemistry and biophysics 465, 157-163.
  38. Shi, Y. Q., Wang, Q. Z., Liao, S. Y., Zhang, Y., Liu, Y. X., and Han, C. S.* (2006) In vitro propagation of spermatogonial stem cells from KM mice, Front Biosci 11, 2614-2622.
  39. Walke, D. W., Han, C., Shaw, J., Wann, E., Zambrowicz, B., and Sands, A. (2001) In vivo drug target discovery: identifying the best targets from the genome, Current opinion in biotechnology 12, 626-631.
  40. Han, C. S.*, Chen, Y., Ezashi, T., and Roberts, R. M. (2001) Antiviral activities of the soluble extracellular domains of type I interferon receptors, PNAS 98, 6138-6143.

写给考生的话:

  “Never discourage anyone who continually makes progress, no matter how slow.”---Plato (427-327 BC)