姓  名: 周 琪
学  科: 发育生物学
电话/传真: +86-010-64807299 / +86-10-64807306
电子邮件: zhouqi@ioz.ac.cn
通讯地址: 北京市朝阳区大屯路甲3号院 中国科学院干细胞与再生医学创新研究院大楼
中国科学院动物研究所 干细胞与生殖生物学国家重点实验室 100101
更多信息: 生殖工程研究组     

简历介绍:

  周琪,博士,研究员,中国科学院院士,发展中国家科学院院士。现任中国科学院副院长、党组成员,兼任北京干细胞与再生医学研究院理事长。曾任国家973计划、863计划、国家重大科学研究计划项目首席科学家,中国科学院干细胞领域战略性科技先导专项首席科学家。在动物克隆、干细胞发育全能性及调控机制、新型干细胞系创建、哺乳动物同性生殖、细胞命运决定、干细胞资源库建立、干细胞临床应用研究等方面取得多项原创性成果。在 Cell, Nature, Science等刊物发表SCI论文200余篇,研究成果多次入选国内、国际年度科技进展。获得国家自然科学奖二等奖、中科院杰出科技成就奖、周光召基金会杰出青年基础科学奖、何梁何利基金科学与技术进步奖、第三届genOway国际转基因技术奖、发展中国家科学院(TWAS)生物学奖等科技奖励。

研究领域:

  生殖、发育、干细胞的基础研究与转化应用。

社会任职:

获奖及荣誉:

承担科研项目情况:

代表论著:

(#为共同第一作者,*为通讯作者)
  1. Wang LY#, Li ZK#, Wang LB#, Liu C#, Sun XH, Feng GH, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL*, Li W*, Zhou Q*. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. (2020) Cell Stem Cell 27(2):315-325.e5. doi: 10.1016/j.stem.2020.05.014.
  2. Peng YJ*, Huang X, Zhou Q*. Ethical and Policy Considerations for Human Embryo and Stem Cell Research in China. (2020) Cell Stem Cell 27(4):511-514. doi: 10.1016/j.stem.2020.09.010.
  3. Fu R#, Yu D#, Ren J#, Li C#, Wang J, Feng G, Wang X, Wan H, Li T, Wang L, Zhang Y, Hai T*, Li W*, Zhou Q*. Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs. (2020) Protein Cell. 11(2):97-107. doi: 10.1007/s13238-019-00676-8.
  4. Cui T#, Jiang L#, Li T#, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W*, Zhou Q*. Derivation of Mouse Haploid Trophoblast Stem Cells. (2019) Cell Rep. 26(2):407-414.e5. doi: 10.1016/j.celrep.2018.12.067.
  5. Li Y#, Wang L#, Zhang L#, He Z#, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y*, Zhou Q*, Li W*. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. (2019) J Cell Biol. 218(5):1553-1563. doi: 10.1083/jcb.201808088.
  6. Wang L#, Wu W#, Gu Q#, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q*, Yin Z*, Hao J*. The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. (2019) Protein Cell. 10(6):455-460. doi: 10.1007/s13238-018-0606-8.
  7. Wang J#, Wang L#, Feng G#, Wang Y#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W*, Zhou Q*. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. (2018) Cell 175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.
  8. Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. (2018) Cell Stem Cell 23(5):665-676.e4. doi: 10.1016/j.stem.2018.09.004.
  9. Li TD#, Feng GH#, Li YF#, Wang M#, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q*. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. (2017) Proc Natl Acad Sci U S A. 114(45):11974-11979. doi: 10.1073/pnas.1708710114.
  10. He ZQ#, Xia BL#, Wang YK#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q*. Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening. (2017) Cell Rep. 20(9):2227-2237. doi: 10.1016/j.celrep.2017.07.081.
  11. Gu Q#, Wang J#, Wang L#, Liu ZX, Zhu WW, Tan YQ, Han WF, Wu J, Feng CJ, Fang JH, Liu L, Wang L, Li W, Zhao XY, Hu BY, Hao J*, Zhou Q*. Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. (2017) Stem Cell Reports 9(1):366-380. doi: 10.1016/j.stemcr.2017.04.017.
  12. Li X#, Cui XL#, Wang JQ#, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and application of mouse-rat allodiploid embryonic stem cells. (2016) Cell 164(1-2):279-292. doi: 10.1016/j.cell.2015.11.035.
  13. Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W*, Zhou Q*, Hu B*. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. (2016) Cell Res. 26(1):135-138. doi: 10.1038/cr.2015.151.
  14. Zhou Q#, Wang M#, Yuan Y#, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY*, Sha J*, Zhou Q*. Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. (2016) Cell Stem Cell 18(3):330-340. doi: 10.1016/j.stem.2016.01.017.
  15. Chen Q#*, Yan M#, Cao Z#, Li X#, Zhang Y#, Shi J#, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E*, Zhai Q*, Zhou Q*. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. (2016) Science 351(6271):397-400. doi: 10.1126/science.aad7977.
  16. Wan H#, Feng C#, Teng F#, Yang S#, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W*, Zhao X*, Zhou Q*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. (2015) Cell Res. 25(2):258-261. doi: 10.1038/cr.2014.158.
  17. Chen Y#, Niu Y#, Li Y#, Ai Z, Kang Y, Shi H, Xiang Z, Yang Z, Tan T, Si W, Li W, Xia X, Zhou Q*, Ji W*, Li T*. Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells. (2015) Cell Stem Cell 17(1):116-124. doi: 10.1016/j.stem.2015.06.004.
  18. Chen T#, Hao YJ#, Zhang Y#, Li MM#, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ*, Yang YG*, Zhou Q*. m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. (2015) Cell Stem Cell 16(3):289-301. doi: 10.1016/j.stem.2015.01.016.
  19. Li X#, Wang JQ#, Wang LY#, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q*. Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. (2015) J Mol Cell Biol. 7(5):486-488. doi: 10.1093/jmcb/mjv055.
  20. Shuai L#, Wang Y#, Dong M#, Wang X#, Sang L, Wang M, Wan H, Luo G, Gu T, Yuan Y, Feng C, Teng F, Li W, Liu X, Li T, Wang L, Wang XJ, Zhao XY, Zhou Q*. Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro. (2015) J Mol Cell Biol. 7(4):326-337. doi: 10.1093/jmcb/mjv044.
  21. Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W,Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q. CRISPR germline engineering—the community speaks. (2015) Nat. Biotechnol. May;33(5):478-486. doi: 10.1038/nbt.3227.
  22. Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi Y-M, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha H-Y, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang S-M, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo S-K, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh S-K, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN*, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan B-Z, Zeng F, Zhou Q. Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI). (2015) Regen. Med.;10(2 Suppl):1-44. doi: 10.2217/rme.14.93.
  23. Wang J#, Hao J#, Bai D, Gu Q, Han W, Wang L, Tan Y, Li X, Xue K, Han P, Liu Z, Jia Y, Wu J, Liu L, Wang L, Li W, Liu Z*, Zhou Q*. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. (2015) Stem Cell Res Ther. 6(1):223. doi: 10.1186/s13287-015-0206-y.
  24. Li W#, Li X#, Li T#, Jiang MG#, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q*. Genetic modification and screening in rat using haploid embryonic stem cells. (2014) Cell Stem Cell 14(3):404-414. doi: 10.1016/j.stem.2013.11.016.
  25. Hai T#, Teng F#, Guo R, Li W, Zhou Q*. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. (2014) Cell Res. 24(3):372-375. doi: 10.1038/cr.2014.11.
  26. Zhou Q*. Balancing the welfare: the use of non-human primates in research. (2014) Trends Genet. 30(11):476-478. doi: 10.1016/j.tig.2014.09.005.
  27. Gu Q#, Hao J#, Hai T#, Wang J#, Jia Y, Kong Q, Wang J, Feng C, Xue B, Xie B, Liu S, Li J, He Y, Sun J, Liu L, Wang L, Liu Z*, Zhou Q*. Efficient generation of mouse ESCs-like pig induced pluripotent stem cells. (2014) Protein Cell. 5(5):338-342. doi: 10.1007/s13238-014-0043-2.
  28. Li W#, Teng F#, Li T, Zhou Q*. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. (2013) Nat. Biotechnol. 31(8):684-686. doi: 10.1038/nbt.2652.
  29. Wan H#, He Z#, Dong M, Gu T, Luo GZ, Teng F, Xia B, Li W, Feng C, Li X, Li T, Shuai L, Fu R, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Parthenogenetic haploid embryonic stem cells produce fertile mice. (2013) Cell Res. 23(11):1330-1333. doi: 10.1038/cr.2013.126.
  30. Zhang Y, Teng F, Luo GZ, Wang M, Tong M, Zhao X, Wang L, Wang XJ*, Zhou Q*. MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells. (2013) J Biol. Chem. 288(33):23659-23665. doi: 10.1074/jbc.M113.475608.
  31. Li W#, Shuai L#, Wan H#, Dong M#, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY*, Zhou Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. (2012) Nature 490(7420):407-411. doi: 10.1038/nature11435.
  32. Sheng C#, Zheng Q#, Wu J#, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z*, Zhou Q*. Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. (2012) Cell Res. 22(1):208-218. doi: 10.1038/cr.2011.175.
  33. Sheng C#, Zheng Q#, Wu J#, Xu Z, Sang L, Wang L, Guo C, Zhu W, Tong M, Liu L, Li W, Liu ZH, Zhao XY, Wang L, Chen Z*, Zhou Q*. Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors. (2012) Cell Res. 22(4):769-772. doi: 10.1038/cr.2012.32.
  34. Gu Q#, Hao J#, Zhao XY, Li W, Liu L, Wang L, Liu ZH, Zhou Q*. Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions. (2012) Protein Cell. 3(1):71-79. doi: 10.1007/s13238-012-2007-8.
  35. Tong M#, Lv Z#, Liu L#, Zhu H#, Zheng QY#, Zhao XY, Li W, Wu YB, Zhang HJ, Wu HJ, Li ZK, Zeng F, Wang L, Wang XJ, Sha JH*, Zhou Q*. Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis. (2011) Cell Res. 21(11):1634-1637. doi: 10.1038/cr.2011.143.
  36. Li W#, Zhao XY#, Wan HF, Zhang Y, Liu L, Lv Z, Wang XJ, Wang L*, Zhou Q*. iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. (2011) Cell Res. 21(3):550-553. doi: 10.1038/cr.2011.25.
  37. Riaz A#, Zhao X#, Dai X#, Li W, Liu L, Wan H, Yu Y, Wang L, Zhou Q*. Mouse cloning and somatic cell reprogramming using electrofused blastomeres. (2011) Cell Res. 21(5):770-778. doi: 10.1038/cr.2010.180.
  38. Niu Y#, Yu Y#, Bernat A#, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P*, Zhang K*, Zhou Q*, Ji W*. Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. (2010) Proc. Natl. Acad. Sci. U. S. A. 107(41):17663-17667. doi: 10.1073/pnas.1006563107.
  39. Zhao XY, Lv Z, Li W, Zeng F*, Zhou Q*. Production of mice using iPS cells and tetraploid complementation. (2010) Nat. Protoc. 5(5):963-971. doi: 10.1038/nprot.2010.61.
  40. Liu L#, Luo GZ#, Yang W#, Zhao X#, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ*, Zhou Q*. Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. (2010) J. Biol. Chem. 285(25):19483-19490. doi: 10.1074/jbc.M110.131995.
  41. Dai X#, Hao J#, Hou XJ#, Hai T, Fan Y, Yu Y, Jouneau A, Wang L, Zhou Q*. Somatic nucleus reprogramming is significantly improved by m-carboxycinnamic acid bishydroxamide (CBHA), a histone deacetylase inhibitor. (2010) J. Biol. Chem. 285(40):31002-31010. doi: 10.1074/jbc.M110.136085.
  42. Zhao XY#, Li W#, Lv Z#, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F*, Zhou Q*. iPS cells produce viable mice through tetraploid complementation. (2009) Nature 461(7260):86-90. doi: 10.1038/nature08267.
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  44. Ma M#, Guo X#, Wang F, Zhao C, Liu Z, Shi Z, Wang Y, Zhang P, Zhang K, Wang N, Lin M, Zhou Z, Liu J, Li Q, Wang L, Huo R*, Sha J, Zhou Q*. Protein expression profile of the mouse metaphase-II oocyte. (2008) J. Proteome Res. 7(11):4821-4830. doi: 10.1021/pr800392s.
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写给考生的话:

  学而不思则罔,思而不学则殆。—《论语》