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姓  名:
戴家银
学  科:
生物化学与分子生物学
电话/传真:
+86-10-64807185 / 
电子邮件:
daijy@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 中国科学院动物生态与保护生物学重点实验室 100101
更多信息:
生态毒理学研究组     
简历:

  戴家银,男,1965年10月生,安徽怀宁人,博士,研究员,博士生导师;中国科学院动物研究所动物生态与保护生物学院重点实验室主任,生态毒理学研究组组长。
  1999年在南京大学获博士学位,2000-2005年先后在同济大学,美国德克萨斯州立大学和美国康乃尔大学从事博士后研究工作。2005年入选中国科学院“百人计划”,2010年国家杰出青年基金获得者。主要从事分子生态毒理学和生物化学研究。近5年来,作为通讯作者在Aquat Toxicol, Arch Toxicol, Environ Sci & Technol等国际学术刊物上发表SCI文章36篇,26篇发表在相关领域的JCR前15%刊物上,被国际同行引用近200次。
  已毕业博士研究生11人(均获得博士学位),硕士研究生9人(均获得硕士学位)。其中,五人获“中国科学院优秀毕业生”称号。已毕业博士生中有4人在美国从事博士后研究工作,2人留所从事研究工作。毕业硕士研究生中,1人在美国伊利诺伊大学-香槟分校攻读博士学位。目前在读博士研究生和硕士研究生共10人。15人次获得国家奖学金、中国科学院“地奥奖学金”、“朱李月华”奖学金和保洁优秀研究生奖学金等。

研究领域:

  本课题组着眼于生态毒理学的国际前沿领域开展工作,研究新型持久性污染物在野生动物体内的分布特征,以及这些污染物对动物的毒性效应及机制,评估新型持久性污染物对野生动物的健康及繁衍的潜在威胁。

  首次摸清了我国圈养野生动物体内全氟烷酸(PFAAs)的分布特征,揭示PFAAs在野生动物体内具有富集及生物放大效应。另外,在大、小熊猫体内发现十溴二苯乙烷(DBDPE)的累积,该结果改变了“十溴二苯乙烷不能被陆生生物利用”的观点,使科学界开始重新审视其生物可利用性和生物效应。

  发现全氟烷酸主要抑制脂肪酸和胆固醇的合成和转运。在哺乳动物肝脏,PFAAs主要通过激活过氧化物酶体增殖剂受体(PPARs)及其下游基因的表达发挥毒性作用。

  发现稀有鮈鲫暴露PFAAs后,雄性个体出现雌雄同体现象,雄鱼肝脏卵黄蛋白酶原mRNA、蛋白,以及雌激素受体表达均升高,提示PFAAs具有潜在的生殖内分泌干扰作用。观察到PFAA能够干扰哺乳动物睾丸类固醇(睾酮和孕酮)的合成,导致血清睾酮水平明显降低。进一步研究揭示了PFAAs生殖内分泌毒性作用的机理-主要通过抑制类固醇激素合成急性调节蛋白(StAR)对胆固醇的转运干扰性激素的合成。

社会任职:
获奖及荣誉:
承担科研项目情况:
  在研项目包括国家杰出青年基金和重点项目,中科院知识创新工程重要方向项目和973项目的课题等。 
代表论著:
  1. Lina Ding, Fuhua Hao, Zhimin Shi, Yulan Wang, Hongxia Zhang, Huiru Tang, and Jiayin Dai*. (2009) Systemic responses to chronic perfluorododecanoic acid exposure studied by integrated metabonomics and transcriptomics. Journal of Proteome Research, 9, 2882-2991.
  2. Xuemei Fang, Yixing Feng, Zhimin Shi and Jiayin Dai*. (2009) Alterations of Cytokines and MAPK Signaling Pathways Are Related to the Immunotoxic Effect of Perfluorononanoic Acid. Toxicological Sciences, 108, 367-376.
  3. Zhimin Shi, Lina Ding, Hongxia Zhang, Yixing Feng, Muqi Xu, Jiayin Dai*. (2009) Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and related genes expressions in male rat. Toxicology Letters, 188, 192-200.
  4. Zhimin Shi, Hongxia Zhang, Lina Ding, Yixing Feng, Muqi Xu, Jiayin Dai*. (2009) The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats. Reproductive Toxicology, 27, 352-359.
  5. Yang Liu, Jianshe Wang, Yong Liu, Hongxia Zhang, Muqi Xu Jiayin Dai*. (2009) Expression of a novel cytochrome P450 4T gene in rare minnow (Gobiocypris rarus) following perfluorooctanoic acid exposure. Comparative Biochemistry and Physiology, Part C, 150, 57-64.
  6. Yixing Feng, Zhimin Shi, Xuemei Fang, Muqi Xu, Jiayin Dai*. (2009) Perfluorononanoic Acid Induces Apoptosis Involving the Fas Death Receptor Signaling Pathway in Rat Testis. Toxicology Letters, DOI: 10.1016/j.toxlet.2009.07.020.
  7. Yanhong Wei, Leo. L. Chan, Dazhi Wang, Hongxia Zhang, Jianshe Wang, Jiayin Dai*. (2008) Proteomic Analysis of Hepatic Protein Profiles in Rare Minnow (Gobiocypris rarus) Exposed to Perfluorooctanoic Acid. Journal of Proteome Research, 7, 1729-1739.
  8. Guocheng Hu, Xiaojun Luo, Jiayin Dai*, Xiulan Zhang, Hua Wu, Chenglin Zhang, Wei Guo, Muqi Xu, Bixian Mai, Fuwen Wei.(2008) Brominated Flame Retardants, Polychlorinated Biphenyls, and Organochlorine Pesticides in Giant Panda (Ailuropoda melanoleuca) and Red Panda (Ailurus fulgens) from China. Environmental Science & Technology, 42, 4697-4703.
  9. Xuemei Li, Leo W.Y. Yeung, Sachi Taniyasu, Ming Li, Hongxia Zhang, Dan Liu, Paul K.S. Lam, and Jiayin Dai*. (2008) Perfluorooctanesulfonate and Related Fluorochemicals in the Amur Tiger (Panthera tigris altaica) from China. Environmental Science & Technology, 42, 7078-7083.
  10. Guocheng Hu, Jiayin Dai*, Muqi Xu, Xiaojun Luo, and Bixian Mai. (2008) Response to Comment on “Brominated Flame Retardants, Polychlorinated Biphenyls, and Organochlorine Pesticides in Captive Giant Panda (Ailuropoda melanoleuca) and Red Panda (Ailurus fulgens) from China. Environmental Science & Technology, 42, 8173-8174.
  11. Yanhong Wei, Yang Liu, Jianshe Wang, Yi Tao, Jiayin Dai*. (2008) Toxicogenomic Analysis of the Hepatic Effects of Perfluorooctanoic Acid on Male and Female Rare Minnows(Gobiocypris rarus). Toxicology and Applied Pharmacology, 226, 285-297.
  12. Hongxia Zhang, Zhimin Shi, Yang Liu, Yanhong Wei, Jiayin Dai*. (2008) Response of Lipid Homeostasis and Oxidative Stress in the Liver of Male Rats Exposed to Perfluorododecanoic acid. Toxicology and Applied Pharmacology, 227, 16-25.
  13. Xuemei Fang, Lianjun Zhang, Yixing Feng, Yong Zhao, Jiayin Dai*. (2008) Immunotoxic Effects of Perfluorononanoic Acid on BALB/c Mice. Toxicological Sciences, 105, 312-21.
  14. Xuemei Li, Leo Wai Yin Yeung, Muqi Xu, Sachi Taniyasu, Paul K.S. Lam, Nobuyoshi Yamashita, Jiayin Dai*. (2008). Perfluorooctane sulfonate (PFOS) and other fluorochemicals in zooplankton and fish collected near the outfall of wastewater treatment plant (WWTP) in Beijing. Environmental Pollution, 156, 1298-1303.
  15. Yong Liu, Jianshe Wang, Yanhong Wei, Hongxia Zhang, and Jiayin Dai*. (2008) Molecular characterization of cytochrome P450 3A and 1A and the effects of perfluorooctanoic acid on their expression in rare minnow (Gobiocypris rarus) gills. Aquatic toxicology, 88, 183-190.
  16. Yang Liu, Jianshe Wang, Yanhong Wei, Hongxia Zhang, Muqi Xu, and Jiayin Dai*. (2008) Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquatic toxicology, 89, 242-250.
  17. Xuemei Li, Leo Wai Yin Yeung, Sachi Taniyasu, Paul K. S. Lam, Nobuyoshi Yamashita, Muqi Xu, Jiayin Dai*. (2008) Perfluorinated compounds in Bengal tiger (Panthera tigris tigris) and African lion (Panthera leo Linnaeus) in China. Chemosphere, 73, 1649-1653.
  18. Jianshe Wang, Yanhong Wei, Dazhi Wang, Leo. L. Chan, and Jiayin Dai*. (2008) Proteomic study of the effects of complex environmental stresses in the livers of goldfish (Carassius auratus) that inhabit Gaobeidian Lake in Beijing, China. Ecotoxicology, 17, 213-220.
  19. Jianshe Wang, Zhiyong Feng, Dandan Yao, Jingjing Sui, Wenqing Zhong, Jiayin Dai*. (2008) Warfarin Resistance in Rattus losea in Guangdong Province, China. Pesticide Biochemistry and Physiology, 91, 90-95.
  20. Lingling Deng, Muqi Xu, Hong Cao, and Jiayin Dai*. (2008) Ecotoxicological effects of buprofezin on fecundity, growth, development and predation of the wolf spider, PIRATA PIRATOIDES (Schenkel), Archives of Environmental Contamination and Toxicology, 55, 652-658.
  21. Xuemei Li, Yiping Gan, Xiangping Yang, Jun Zhou, Jiayin Dai, Muqi Xu. (2008) Human health risk of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in edible fish from Huairou Reservoir and Gaobeidian Lake in Beijing, China. Food Chemistry, 109, 348-354.
  22. Xuemei Li, Qinghua Zhang, Jiayin Dai, Yiping Gan, Jun Zhou, Xiangping Yang, Hong Cao, Guibin Jiang, Muqi Xu. (2008) Pesticide contamination profiles of water, sediment and aquatic organisms in the effluent of Gaobeidian Wastewater Treatment Plant. Chemosphere, 72, 1145-1151.
  23. Jun Xu, Min Yang,Jiayin Dai, Hong Cao , Canping Pan, Xinghui Qiu, Muqi Xu. (2008) Degradation of acetochlor by four microbial communities, Bioresource Technology, 99, 7797-7802.
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