姓  名: 赵同标
学  科: 再生医学
电话/传真: +86-10-64806307 / 
电子邮件: tbzhao@ioz.ac.cn or tongbiaozhao@gmail.com
通讯地址: 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100101
更多信息: 干细胞与免疫学研究组     

简历介绍:

  赵同标,男,博士,研究员,博士生导师;干细胞与生殖生物学国家重点实验室干细胞与免疫学研究组组长;中国科学院大学岗位教授;国家重点研发计划“干细胞制剂及应用标准化”项目首席科学家。
  2004年毕业于中科院西高所获博士学位,进入中科院生物物理所博士后流动站从事免疫学研究,2006年获该所副研究员任职资格;2007年至2010年在加州大学圣地亚哥分校做博士后,从事多能干细胞研究,2010年任该校Assistant Specialist III;2012年入选中组部“青年千人计划”,加入中科院动物研究所,组建干细胞与免疫学实验室。承担国家重点研发计划、中国科学院战略先导专项、国家自然科学基金重点国际合作研究等项目。任国际标准化组织/生物技术委员会(ISO/TC276)委员、中国细胞生物学会干细胞生物学分会委员、标准工作组组长和中华医学会组织修复与再生分会青年委员。是《Animal Models and Experimental Medicine》、《科学通报》和《发育医学电子杂志》等期刊编委。
  主要从事干细胞移植免疫和干细胞转化相关工作,在诱导多能干细胞(iPS)免疫原性、干细胞代谢及干细胞标准化领域做了系统的工作。率先应用完全非整合iPS纯系四倍体补偿小鼠评估了“最理想条件下”iPS分化的组织器官的功能与免疫原性;率先应用人源化小鼠发现人iPS分化过程中免疫原性呈差异性呈递;首次发现小鼠iPS细胞分化的自体同源组织具有免疫原性;系统阐明了自噬在多能干细胞线粒体动态平衡调控及干性维持中的关键作用等;组织撰写多项国际、国内干细胞标准草案,发布了首个干细胞通用标准《干细胞通用要求》和干细胞专用标准《人胚胎干细胞》。在Autophagy、Nature Communications、Cell Stem Cell、Nature 等国际主流杂志发表多篇论文。iPS免疫原性的发现对于干细胞研究的发展方向具有指导意义;干细胞标准工作对于干细胞转化应用的规范化发展具有重要意义。

研究领域:

  研究组围绕干细胞基础与临床转化研究中的免疫学问题,重点聚焦于以下研究方向:(1)干细胞临床转化的免疫学基础;(2)干细胞命运决定的物质能量代谢基础;(3)多能干细胞的定向分化。

社会任职:

获奖及荣誉:

承担科研项目情况:

代表论著:

  1. Gu H#, Shi X#, Liu C#, Wang W#, Shi N, Zhao Y, Gong J, Wang F, Zhang H, Li W*, Zhao T*. USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nature Communications, 2019, 10: 1465. DOI: 10.1038/s41467-019-09430-4
  2. Gong J#, Gu H#, Zhao L#, Wang L, Liu P, Wang F, Xu H, Zhao T*. Phosphorylation of ulk1 by ampk is essential for mouse embryonic stem cell self-renewal and pluripotency. Cell Death & Disease, 2018, 9(2): 38.  DOI: 10.1038/s41419-017-0054-z
  3. Liu P#, Liu K#, Gu H, Wang W, Gong J, Zhu Y, Zhao Q, Cao J, Han C, Gao F, Chen Q, Li W, Jiao J, Hu B, Zhou Q, Zhao T*. High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death and Differentiation, 2017, 24(10): 1672-1680. DOI: 10.1038/cdd.2017.90
  4. Sun H#, Cao J#, Zhao L#, Zhu S, Chen S, Li Y, Zhao B, Zhao T*. PIM2 regulates stemness through phosphorylation of 4E-BP1. Science Bulletin, 2017, 62(10): 679-685. (Cover story)  DOI:org/10.1016/j.scib.2017.04.018
  5. Liu K#, Zhao Q#, Liu P#, Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S, Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou Q*, Zhao T*. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 2016, 12(11): 2000-2008. DOI: 10.1080/15548627.2016.1212786
  6. Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T*. p18 inhibits reprogramming through inactivation of Cdk4/6. Scientific Reports, 2016, 6: 31085. DOI: 10.1038/srep31085
  7. Zhang C, Cao J, Li X, Xu H, Wang W, Wang L, Zhao X, Li W, Jiao J, Hu B, Zhou Q*, Zhao T*. Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Science China Life Sciences, 2016, 59(9): 950-957. DOI: 10.1007/s11427-016-0114-9
  8. Zhao T#, Zhang Z#, Westenskow P#, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg D, Yang Y, Zhang K, Friedlander M, Xu Y*. Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell, 2015, 17(3): 353-359. DOI: 10.1016/j.stem.2015.07.021
  9. Wang L#, Cao J#, Wang Y#, Lan T#, Liu L, Wang W, Jin N, Gong J, Zhang C, Teng F, Yan G, Li C, Li J, Wan H, Hu B, Li W, Zhao X, Qi Z*, Zhao T*, Zhou Q*. Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discovery, 2015, 1: 15015. DOI: 10.1038/celldisc.2015.15
  10. Zhao T, Zhang Z, Rong Z, Xu Y*. Immunogenicity of induced pluripotent stem cells. Nature, 2011, 474(7350): 212-216. DOI: 10.1038/nature10135
    • Highlighted by Nature (Nature 474:165); Nature Medicine (Nature Medicine 17: 670)
    • Recommended by Faculty of 1000 (F1000.com/11136956)
    • Reported by Nature, Science, New York Time, New Scientist, ScienceDaily, UK Guardian, USA today et al.
  11. Hou Q#, Zhao T#, Zhang H, Lu H, Zhang Q, Sun L, Fan Z*. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Molecular Immunology, 2008, 45(4): 1044-1055. DOI: 10.1016/j.molimm.2007.07.032
  12. Zhao T#, Zhang H#, Guo Y, Fan Z*. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. Journal of Biological Chemistry, 2007, 282(16): 12104-12111. DOI: 10.1074/jbc.M611006200
  13. Zhao T#, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z*. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death and Differentiation, 2007, 14(3): 489-499. DOI: 10.1038/sj.cdd.4402040

综述论文

  1. Wang L#, Ye X#, Zhao T*. The physiological roles of autophagy in the mammalian life cycle. Biological Reviews, 2019, 94: 503-516. DOI: 10.1111/brv.12464
  2. Cao J, Zhao T*. Single-cell sequencing delivers hematopoietic stem cell specification. Science Bulletin, 2016, 61(18): 1419-1421. DOI: 10.1007/s11434-016-1163-2
  3. Liu K#, Song Y#, Yu H#, Zhao T*. Understanding the roadmaps to induced pluripotency. Cell Death and Disease, 2014, 5: e1232. DOI: 10.1038/cddis.2014.205
  4. Cao J#, Li X#, Lu X, Zhang C, Yu H, Zhao T*. Cells derived from iPSC can be immunogenic – Yes or No? Protein Cell, 2014, 5(1): 1-3. DOI: 10.1007/s13238-013-0003-2
  5. Lu X, Zhao T*. Clinical therapy using iPSCs: hopes and challenges. Genomics Proteomics Bioinformatics, 2013, 11(5): 294-298. DOI: 10.1016/j.gpb.2013.09.002
  6. Zhao T, Xu Y*. p53 and stem cells: new developments and new concerns. Trends in Cell Biology, 2010, 20(3): 170-175. DOI: 10.1016/j.tcb.2009.12.004

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