2002年毕业于兰州大学生物基地班获学士学位，2007年毕业于中国科学院生物物理研究所获博士学位，2007-2012年间分别在美国圣迭戈Sanford-Burnham医学研究所以及Salk生物学研究所进行博士后研究，2014年加入中科院动物研究所成立干细胞与衰老研究课题组。

　　承担国家杰出青年基金项目“衰老与再生”（项目负责人），承担国家重点研发计划“灵长类增龄相关健康状态减损的生物学基础”项目（首席科学家）、国家自然科学基金重大研究计划“器官衰老与器官退行性变化的机制”重点支持项目（项目负责人）、中科院“王宽诚率先人才计划卢嘉锡国际团队衰老与再生调控团队”项目（项目负责人），作为项目骨干加入国家自然科学基金“衰老机制及调控”创新群体。

　　作为主要贡献人获中国科学院杰出科技成就奖，及中华医学科学技术奖等奖项。担任中国科学院大学存济医学院医学发育生物学首席教授，中国生物物理学会衰老生物学分会副会长、以及PLoS Biology, Cell Proliferation, Frontiers in Cell and Developmental Biology, Zoological Research, The Innovation等杂志编委会成员。研究工作以通讯和第一（包括共同）作者共发表Cell（2篇），Nature（2篇），Science等在内SCI论文84篇；获授权发明专利29项，包括PCT 2项；部分工作入选“国家十三五科技创新成就展”基础研究重大成果，中国科学十大进展, 中国生命科学十大进展（2次）。

　　关注人类衰老及退行性疾病发生发展过程中，组织乃至细胞特异的生理或病理变化，发现器官退行或病变的标志物，系统解析驱动因素，发现延缓器官失稳，促进原位再生的关键基因或候选小分子，发展干预人类器官退变的有效手段。

• 2022-2026 国家自然基金杰青项目，主持，在研
• 2018-2022 国家重点研发计划，主持，在研
• 2020-2023 国家自然科学基金重大研究计划重点支持项目，主持，在研
• 2015-2017 国家自然科学基金委优青项目，主持，结题

1. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Jiang X, Wang C, Wang Q, Li L, Yan K, Ji Q, Li W, Ji Z, Cai Y, Wang S, Zheng A, Song M, Lu F, Zhang Y, Ji W, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence. bioRxiv. 2021.02.22.432260; doi: https://doi.org/10.1101/2021.02.22.432260.
2. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces systemic rejuvenation and stem cell revitalization across aged tissues. Cell Stem Cell. 2022. 29(6):990-1005.
3. Liu GH*, Qu J*. Longevity secret - a pluripotent superpower. Cell Metabolism. 2022. 34(6):803-804.
4. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes that Drive Cellular Aging. Developmental Cell. 2022. 57(11):1347-1368.
5. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging. 2022. DOI: 10.1038/s43587-022-00186-z.
6. Liu ZP, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JD, Hernandez-Benitez R, Shyh-Chang Ng, Izpisua Belmonte JC, Zhang WQ*, Qu J*, Liu GH*. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discovery. 2022. 1;8(1):6.
7. He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Zhang W, Liu GH*, Wang S*, Song M*, Qu J*. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. Protein Cell. 2022. DOI: 10.1093/procel/pwac037.
8. Zhang Y, Zheng Y, Wang S, Fan Y, Ye Y, Jing Y, Liu Z, Yang S, Xiong M, Yang K, Hu J, Che S, Chu Q, Song M, Liu GH*, Zhang W*, Ma S*, Qu J*. Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging. Protein Cell. 2022. DOI: 10.1093/procel/pwac038.
9. Yan H, Wang R, Ma S, Huang D, Wang S, Ren J, Lu C, Chen X, Zhang W*, Qu J*, Zhou Y*, Liu GH*. Lineage Landscape: A comprehensive database that records lineage commitment across species. Nucleic Acids Research. 2022. In press.
10. Ji Z, Liu GH*, Qu J*. Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics. 2022. 49(4):287-298.
11. Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang CL, Ying Y, Dou X, Chen Y, Xiao FH, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S*, Wang S*, Song X*, Ren J*, Zhang L*, Wang J*, Zhang W*, Xie Z*, Qu J*, Wang J*, Xiao Y*, Tian Y*, Wang G*, Hu P*, Ye J*, Sun Y*, Mao Z*, Kong QP*, Liu Q*, Zou W*, Tian XL*, Xiao ZX*, Liu Y*, Liu JP*, Song M*, Han JJ*, Liu GH*. The landscape of aging. Science China Life Science. 2022 2:1-101.
12. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Tang F*, Liu GH*. A Genome-wide CRISPR-Based Screen Identifies KAT7 as a Senescence Driver. Science Translational Medicine. 2021.13, Jan 6;13(575):eabd2655.
13. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021. 31(2):187-205.
14. Li J, Zheng Y, Yan P, Song M, Wang S, Sun L, Liu Z, Ma S, Chan P, Zhou Q, Belmonte JC, Zhang W*, Liu GH*, Tang F*, Qu J*. A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging. National Science Review. 2021.Feb; 8(2):nwaa127.
15. Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH*, Wang S*, Song M*, Qu J*. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Research. 2021 (Breakthrough) Mar 12;gkab161.
16. Aging Atlas Consortium, Zhang W*, Qu J *, Bao Y*, Liu GH*. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021. 49(D1):D825-D830.
17. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Wang S, He Y, Esteban CR, Huang J, Yu N, Chan P, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of human skin aging. Developmental Cell. 2021. 56(3):383-397 (Cover story)
18. Lei J; Wang S; Kang W; Chu Q; Liu Z; Sun L; Ji Y; Esteban CR; Yao Y; Belmonte JC; Chan P; Liu GH*; Zhang W*; Song M*; Qu J*. FOXO3-Engineered Human Mesenchymal Progenitor Cells Efficiently Promote Cardiac Repair after Myocardial Infarction. Protein Cell. 2021. 12(2):145-151.
19. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020 Mar 5;180(5):984-1001.e22
20. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC*, Qu J*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020 Feb 6;180(3):585-600.e19. (Cover Story)
21. Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH*, Tang F*, Qu J*. A Single-Cell Transcriptomic landscape of Primate Arterial Aging. Nature Communications. 2020 May 5;11(1):2202.
22. Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang Y, Liu GH*, Zhang W*, Ci W*, Qu J*. METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA. Nucleic Acids Research. 2020 Nov 4;48(19):11083-11096
23. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Wang S*, Zhang W*, Liu GH*, Qu J*. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Research. 2020 Jun 19;48(11):6001-6018.
24. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Zhang W*, Song M*, Liu GH*, Qu J*. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020. 11(7):483-504.
25. He X, Memczak S, Qu J*, Belmonte JC*, Liu GH*. Single-cell “OMICS” in aging: a young growing field. Nature Metabolism. 2020. 2: 293–302.
26. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870.
27. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J*, Tang F*, Liu GH*. FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell. 2019. 24(3):447-461 (Cover story)
28. Wang S*, Zheng Y, Li Q, He X, Ren R, Zhang W, Song M, Hu H, Liu F, Sun G, Sun S, Liu Z, Yu Y, Chan P, Zhao GG, Zhou Q, Liu GH*, Tang F* Qu J*. Deciphering primate retinal aging at single-cell resolution. Protein Cell. 2019. 10(10):770-775.
29. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W*, Song M*, Liu GH*, Qu J*. Telomere-Dependent and Telomere-Independent Roles of RAP1 in Regulating Human Stem Cell Homeostasis. Protein Cell. 2019. 10(9):649-667.
30. Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M*, Zhang W*, Liu GH*, Qu J*. Low-dose quercetin positively regulates mouse healthspan. Protein Cell. 2019. 10(10):770-775.