姓  名: 张 莹
学  科: 发育生物学
电话/传真: +86-10-64807182 / +86-10-64807310
电子邮件: zhangying@ioz.ac.cn
通讯地址: 北京市朝阳区大屯路甲3号干细胞与再生医学创新研究院557 100101
更多信息: 胚胎生物学研究组     

简历介绍:

  2005年北京师范大学生命科学学院获学士学位后,在中国科学院动物研究所干细胞与生殖生物学国家重点实验室继续攻读。2011年博士毕业后留所担任助理研究员,2016年担任胚胎生物学研究组副研究员,主要从事妊娠建立和表观遗传相关研究。以第一作者/共同第一作者/通讯作者的身份在Nature Cell Biology, Nature Reviews Endocrinology, Cell Research, Trends in Molecular Medicine, Molecular Aspects of Medicine, Development, Journal of Molecular Cell Biology, Journal of Biological Chemistry, Biology of Reproduction等杂志发布论文18篇,参与工作发表在Science等重要杂志上;研究论文被Cell Press报道,入选F1000推送,并作为cover story受到Trends in Molecular MedicineJournal of Molecular Cell Biology的编辑推荐。主持国家自然科学基金面上项目一项、青年项目一项、科技部973子项目课题一项、重点研发计划三级课题一项,入选中国科学院青年促进会并获人才项目支撑,作为主要骨干参与两项重点研发专项。

研究领域:

  妊娠建立及小RNA研究。

社会任职:

  目前担任Journal of Biological Chemistry, Reproduction, scientific reports, Fertility & Sterility, PloS ONE, Biology of Reproduction等学术期刊的ad hoc审稿人。

获奖及荣誉:

  • 2015年入选中国科学院青年创新促进会
  • 2015年获中国生理学会生殖科学专业委员会2015年青年科技奖
  • 2015年获首届妇幼健康科学技术奖一等奖(第4完成人)
  • 2011年获全国人口和计划生育优秀科技成果一等奖(第8完成人)

承担科研项目情况:

  主持一项国家面上基金“胚胎植入期外泌体小RNA介导妊娠识别和建立的研究”(2017-2020)

代表论著:

  1. Zhang Y#, Chen Q#. Human ‘sperm RNA code’ senses dietary sugar. Nature Reviews Endocrinology. 2020 Apr;16(4):200-201. doi:10.1038/s41574-020-0331-2
  2. Qian J, Chen Q, Sean M. Ward, Duan E#., Zhang Y#. Impacts of caffeine during pregnancy. Trends in Endocrinology and Metabolism. 2019 Dec 6. pii: S1043-2760(19)30226-7. (封面故事)
  3. Zhang Y, Qian J, Oren Z, Mustafa B, Ariel J.J, Dan G, Duan E, David E. Analysis of in vivo uterine peristalsis in the non-pregnant female mouse. Interface Focus. 2019 Aug 6;9(4):20180082.
  4. Zhang Y, Chen Q. The expanding repertoire of hereditary information carriers. Development. 2019 Mar 15;146(6). pii: dev170902
  5. Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao z, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y#, Zhou Q#, Duan E#, Chen Q#. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology 2018; 20:535-540. (英国双院院士在Nature Review Endocrinology上专题点评)
  6. Zhang Y, Duan E. LncRNAs and paraspeckles predict cell fate in early mouse embryo. Biology of Reproduction. 2019 May 1;100(5):1129-1131.
  7. Qian J, Zhang Y, Qu Y, Zhang L, Shi J, Zhang X, Liu S, Kim BH, Hwang SJ, Zhou T, Chen Q, Ward SM, Duan E#, Zhang Y#. Caffeine consumption during early pregnancy impairs oviductal embryo transport, embryonic development and uterine receptivity in mice. Biology of Reproduction 2018; Dec 1;99(6):1266-1275
  8. Zhang Y*, Wang Q*, Wang H, Duan E. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends in Molecular Medicine. 2017 Jul;23(7):604-614. (封面故事 & Cell Press点评 &入选F1000)
  9. Zhang Y*, Chen Q*, Zhang H*, Wang Q*, Li R, Jin Y, Wang H, Ma T, Qiao J, Duan E. Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Research. 2015 Jan;25(1):139-42. (SMPC新闻采访/报道)
  10. Zhang Y*, Zhang Y*, Shi J*, Zhang H, Cao Z, Gao X, Ren W, Ning Y, Ning L, Cao Y, Chen Y, Ji W, Chen ZJ, Chen Q, Duan E. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection. Journal of Molecular Cell Biology, 2014, 6 (2): 172-174. (封面故事 & 编辑推荐)
  11. Chen Q*, Zhang Y*, Elad D, Jaffa AJ, Cao Y, Ye X, Duan E. Navigating the site for embryo implantation: biomechanical and molecular regulation of intrauterine embryo distribution. Molecular Aspects of Medicine, 2013, Oct;34(5):1024-42.
  12. Lu S, Peng H, Zhang H, Zhang L, Cao Q, Li R, Zhang Y#, Yan L#, Duan E, Qiao J. Excessive intrauterine fluid cause aberrant implantation and pregnancy outcome in mice. PLoS One, 2013 Oct 23;8(10):e78446.
  13. Zhang H*, Zhang Y*, Zho H, Zhang Y, Chen Q, Peng H, Lei L, Qiao J, Shi J, Cao Z, Duan E, Jin Y. Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins. PLoS One, 2013 May 22; 8(5): e63823.
  14. Chen Q*, Zhang Y*, Peng H, Lei L, Kuang H, Zhang L, Ning L, Cao Y, Duan E. Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation. Journal of Biology Chemistry 2011, 286: 4349-4356.
  15. Zhang Y*, Zhao H, Peng H, Hu Z, Ning L, Cao Y, Tan Y, Duan E. GPR39, a putative receptor of Zn2+, is region specifically localized in different lobes of mouse prostate. Urology, 2011, Apr;77(4):1010.e1-6.
  16. Peng H*, Zhang Y*, Lei L#, Chen Q, Yue J, Tan Y, Duan E. Aquaporin 7 expression in postimplantation mouse uteri: a potential role for glycerol transport in uterine decidualization. Fertility and Sterility 2011 95: 1514-1517.
  17. Zhang Y, Peng S, Kuang H, Chen Q, Liu S, Zhang L, Duan E. Expression and regulation of Dickkopf2 during periimplantation in mice. Journal of Reproductive and Development 2009 55: 17-22.
  18. Chen Q*, Zhang Y*, Lu J, Wang Q, Wang S, Cao Y, Wang H, Duan E. Embryo-uterine cross-talk during implantation: the role of Wnt signaling. Molecular Human Reproduction 2009 15: 215-221.

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