研究队伍
院士专家
青年千人
百人计划
杰出青年
研究员
副研究员
人才招聘
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姓  名:
翟巍巍
学  科:
进化遗传学
电话/传真:
+86-10-64801720 / 
电子邮件:
weiweizhai@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 中国科学院动物进化与系统学重点实验室 100101
更多信息:
进化与群体基因组学研究组     
简历:
  翟巍巍,男,出生于江苏南通,博士,研究员,博士生导师, 中国科学院动物所进化与群体基因组学研究组组长。中组部第14批青年千人入选者。2002年毕业于中国科学技术大学生物系,先后在2004和2008年从美国康奈尔大学和加州大学伯克利分校取得生物统计的硕士和群体遗传学博士。2009年6月回到中国科学院北京基因组研究所工作(任副研究员)。2013年9月到2018年6月,在新加坡基因组研究所工作(PI)。主要从事群体遗传学,分子进化,细胞的种群遗传学等研究方向上的研究。在人类的演化(例如尼安德特人的起源进化),家犬和水稻的起源进化,以及东亚的肝癌和肺癌的肿瘤异质性和进化上等研究上做出了原创的科学发现。
研究领域:
  群体遗传学,分子进化,基因组学,肿瘤基因组学,计算生物学。
社会任职:
获奖及荣誉:
  • 2010年,AAAS Newcomb Cleveland Prize (Joint work on the Neaderthal project)
  • 2012年,中国科学院青年创新促进会
  • 2017年,Sanofi-Cell Research outstanding paper award of 2016 (joint work on dog evolution)
承担科研项目情况:
  中组部青年千人计划 2018-2020。
代表论著:
  1. Nahar R*, Zhai W*, Zhang T*, Takano A, Khng AJ, Lee YY, Liu X, Lim CH, Koh TPT, Aung ZW, Lim TKH, Veer avalli L, Yuan J, Teo ASM, Chan CX, Poh HM, Chua IML, Liew AA, Lau DPX, Kwang XL, Toh CK, Lim WT, Lim B, Tam WL, Tan EH, Hillmer AM#, Tan DSW# "Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing." Nat Commun 2018 Jan 15 ; 9(1) : 216 (* Equal contribution)
  2. Zhao Y, Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y, Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE, Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q "Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy." Gut 2018 Mar 30
  3. Yang H, Wang G, Wang M, Ma Y, Yin T, Fan R, Wu H, Zhong L, Irwin DM, Zhai W#, Zhang Y# "The origin of chow chows in the light of the East Asian breeds." BMC Genomics 2017 Feb 16 ; 18(1) : 174 (# Co-corresponding)
  4. Zhai W*,#, Lim TK*, Zhang T*, Phang ST, Tiang Z, Guan P, Ng MH, Lim JQ, Yao F, Li Z, Ng PY, Yan J, Goh BK, Chung AY, Choo SP, Khor CC, Soon WW, Sung KW, Foo RS#, Chow PK# "The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma." Nat Commun 2017 Feb 27 ; 8 : 4565 (* Joint first, # Corresponding authors)
  5. Liu YH, Wang L, Xu T, Guo X, Li Y, Yin TT, Yang HC, Yang H, Adeola AC, J Sanke O, O Otecko N, Wang M, Ma Y, S Charles O, S Sinding MH, Gopalakrishnan S, Samaniego JA, Hansen AJ, Fernandes C, Gaubert P, Budd J, M Dawuda P, Rueness EK, Jiang L, Zhai W, Gilbert MTP, Peng MS, Qi X, Wang GD, Zhang YP "Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites." Mol Biol Evol 2017 Oct 10
  6. Tan WL, Jain A, Takano A, Newell EW, Iyer NG, Lim WT, Tan EH, Zhai W, Hillmer AM, Tam WL, Tan DS "Novel therapeutic targets on the horizon for lung cancer." Lancet Oncol 2016 Aug ; 17(8) : e347-62
  7. Wu Z, Periaswamy B, Sahin O, Yaeger M, Plummer P, Zhai W, Shen Z, Dai L, Chen SL, Zhang Q "Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni." Proc Natl Acad Sci U S A 2016 Sep 20 ; 113(38) : 10690-5 Epub 2016 Sep 6
  8. Chen H, Deng Q, Ng SH, Lee RT, Maurer-Stroh S, Zhai W "Dynamic Convergent Evolution Drives the Passage Adaptation across 48 Years' History of H3N2 Influenza Evolution." Mol Biol Evol 2016 Sep 7 Epub 2016 Sep 7
  9. Wang GD*, Zhai W*, Yang HC*, Wang L*, Zhong L, Liu YH, Fan RX, Yin TT, Zhu CL, Poyarko v AD, Irwin DM, Hyt?nen MK, Lohi H, Wu CI, Savolainen P#, Zhang YP# "Out of southern East Asia: the natural history of domestic dogs across the world." Cell Res 2015 Dec 15 (* Equal contribution, Cover story)
  10. Wang GD, Fan RX, Zhai W, Liu F, Wang L, Zhong L, Wu H, Yang HC, Wu SF, Zhu CL, Li Y, Gao Y, Ge RL, Wu CI, Zhang YP "Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau." Genome Biol Evol 2014 Aug ; 6(8) : 2122-8
  11. Hu Z, Fu YX, Greenberg AJ, Wu CI#, Zhai W# "Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis." PLoS Genet 2013 ; 9(2) : e1003326 Epub 2013 Feb 28 (# co-corresponding author)
  12. Wang GD*, Zhai W*, Yang HC, Fan RX, Cao X, Zhong L, Wang L, Liu F, Wu H, Cheng LG, Poyarkov AD, Poyarkov NA, Tang SS, Zhao WM, Gao Y, Lv XM, Irwin DM, Savolainen P, Wu CI#, Zhang YP# "The genomics of selection in dogs and the parallel evolution between dogs and humans." Nat Commun 2013 ; 4 : 1860 (* joint first author)
  13. Chong Z*, Zhai W*, Li C, Gao M, Gong Q, Ruan J, Li J, Jiang L, Lv X, Hungate E, Wu CI# "The evolution of small insertions and deletions in the coding genes of Drosophila melanogaster." Mol Biol Evol 2013 Dec ; 30(12) : 2699-708 Epub 2013 Sep 26 (* joint first author)
  14. Ruan J, Jiang L, Chong Z, Gong Q, Li H, Li C, Tao Y, Zheng C, Zhai W, Turissini D, Cannon CH, Lu X, Wu CI "Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology." BMC Genomics 2013 ; 14 : 711 Epub 2013 Oct 17
  15. Zhai W, Nielsen R, Goldman N, Yang Z "Looking for Darwin in genomic sequences--validity and success of statistical methods." Mol Biol Evol 2012 Oct ; 29(10) : 2889-93 Epub 2012 Apr 3
  16. Sun M, Gao L, Liu Y, Zhao Y, Wang X, Pan Y, Ning T, Cai H, Yang H, Zhai W#, Ke Y #"Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China." PLoS One 2012 ; 7(5) : e36577 Epub 2012 May 4 (# co-corresponding author)
  17. He Z*, Zhai W*, Wen H*, Tang T, Wang Y, Lu X, Greenberg AJ, Hudson RR, Wu CI#, Shi S# "Two evolutionary histories in the genome of rice: the roles of domestication genes." PLoS Genet 2011 Jun ; 7(6) : e1002100 Epub 2011 Jun 9 (* joint first author)
  18. Tao Y*, Ruan J*, Yeh SH*, Lu X*, Wang Y*, Zhai W*, Cai J*, Ling S, Gong Q, Chong Z, Qu Z, Li Q, Liu J, Yang J, Zheng C, Zeng C, Wang HY, Zhang J, Wang SH, Hao L, Dong L, Li W, Sun M, Zou W, Yu C, Li C, Liu G, Jiang L, Xu J, Huang H, Li C, Mi S, Zhang B, Chen B, Zhao W, Hu S, Zhuang SM, Shen Y, Shi S, Brown C, White KP, Chen DS#, Chen PJ#, Wu CI# "Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data." Proc Natl Acad Sci U S A 2011 Jul 19 ; 108(29) : 12042-7 Epub 2011 Jul 5 (* joint first author)
  19. Rasmussen M, Guo X, Wang Y, Lohmueller KE, Rasmussen S, Albrechtsen A, Skotte L, Lindgreen S, Metspalu M, Jombart T, Kivisild T, Zhai W, Eriksson A, Manica A, Orlando L, De La Vega FM, Tridico S, Metspalu E, Nielsen K, ávila-Arcos MC, Moreno-Mayar JV, Muller C, Dortch J, Gilbert MT, Lund O, Wesolowska A, Karmin M, Weinert LA, Wang B, Li J, Tai S, Xiao F, Hanihara T, van Driem G, Jha AR, Ricaut FX, de Knijff P, Migliano AB, Gallego Romero I, Kristiansen K, Lambert DM, Brunak S, Forster P, Brinkmann B, Nehlich O, Bunce M, Richards M, Gupta R, Bustamante CD, Krogh A, Foley RA, Lahr MM, Balloux F, Sicheritz-Pontén T, Villems R, Nielsen R, Wang J, Willerslev E "An Aboriginal Australian genome reveals separate human dispersals into Asia." Science 2011 Oct 7 ; 334(6052) : 94-8 Epub 2011 Sep 22
  20. Green RE*, Krause J*, Briggs AW*, Maricic T*, Stenzel U*, Kircher M*, Patterson N*, Li H, Zhai W, Fritz MH, Hansen NF, Durand EY, Malaspinas AS, Jensen JD, Marques-Bonet T, Alkan C, Prüfer K, Meyer M, Burbano HA, Good JM, Schultz R, Aximu-Petri A, Butthof A, H?ber B, H?ffner B, Siegemund M, Weihmann A, Nusbaum C, Lander ES, Russ C, Novod N, Affourtit J, Egholm M, Verna C, Rudan P, Brajkovic D, Kucan Z, Gusic I, Doronichev VB, Golovanova LV, Lalueza-Fox C, de la Rasilla M, Fortea J, Rosas A, Schmitz RW, Johnson PL, Eichler EE, Falush D, Birney E, Mullikin JC, Slatkin M, Nielsen R, Kelso J, Lachmann M, Reich D, P??bo S "A draft sequence of the Neandertal genome." Science 2010 May 7 ; 328(5979) : 710-22
  21. Zhai W, Nielsen R, Slatkin M "An investigation of the statistical power of neutrality tests based on comparative and population genetic data." Mol Biol Evol 2009 Feb ; 26(2) : 273-83 Epub 2008 Oct 14
  22. Zhai W, Slatkin M, Nielsen R "Exploring variation in the d(N)/d(S) ratio among sites and lineages using mutational mappings: applications to the influenza virus." J Mol Evol 2007 Sep ; 65(3) : 340-8 Epub 2007 Sep 11
  23. Zhai W, Todd MJ, Nielsen R "Is haplotype block identification useful for association mapping studies?" Genet Epidemiol 2004 Jul ; 27(1) : 80-3 
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