姓  名: 宋默识
学  科: 生理学与病理生理学
电话/传真: +86-10-64809624 / 
电子邮件: songmoshi@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号 中国科学院动物研究所 膜生物学国家重点实验室 100101
更多信息: 线粒体与疾病研究组     

简历介绍:

  宋默识,中国科学院动物研究所膜生物国家重点实验室研究员。2011年于瑞典卡罗琳斯卡医学院获医学硕士学位,2015年于美国圣路易斯华盛顿大学获理学博士学位,后于美国斯坦福大学从事心血管方面的博士后研究。2018年初加入中国科学院动物研究所成立线粒体与疾病研究组。致力于线粒体调控心脏稳态和衰老的机制和干预研究,近五年发表SCI论文30余篇,Google Scholar引用次数>1200,其中以(共同)第一作者身份在Science、Cell、Cell Metabolism (3篇)、Circulation Research (3篇)、Nature Communications、Cell Reports、Science Signaling、Nucleic Acids Research等国际权威杂志发表SCI论文16篇 (平均IF>15),以通讯/共同通讯作者发表论文8篇。
  现有博士研究生2名、硕士研究生3名、联合培养研究生2名。

研究领域:

  线粒体与心脏疾病和衰老

社会任职:

  • 中国老年学和老年医学学会抗衰老分会副秘书长
  • 中国动物学会理事
  • 中国细胞生物学学会衰老细胞生物学分会委员
  • 中国生理学会老龄生理学专业委员会委员
  • 美国心脏协会(AHA)会员
  • 国际心脏病研究会北美分会(ISHR-NAS)会员
  • Circulation Research、Autophagy、FASEB Journal、Aging Cell、Stem Cell Reports等杂志独立审稿人

获奖及荣誉:

  • 2019年 中国科学院青年学习标兵
  • 2018年 中国干细胞第八届年会青年论坛最佳人气奖
  • 2018年 中国心脏大会基础研究青年学者奖
  • 2018年 美国心脏协会 (AHA) Postdoctoral Fellowship
  • 2017年 EMBO Workshop线粒体质量控制研讨会最佳海报奖
  • 2016年 圣路易斯华盛顿大学Olin Medical Science Fellow奖
  • 2015年 圣路易斯华盛顿大学Barbara Jakschik Award奖
  • 2015年 中国国家优秀留学生奖
  • 2015年 美国心脏协会心血管基础研究协会年会 (BCVS) 优秀青年研究学者奖
  • 2015年 国际心脏病研究会北美分会年会 (ISHR-NAS) 优秀青年研究学者奖
  • 2014年 美国心脏协会 (AHA) Predoctoral Fellowship
  • 2014年 《Circulation Research》杂志年度最佳论文奖
  • 2014年 Gordon Research Conference心脏调节机制研讨会最佳海报奖
  • 2013年 Keystone Symposium心脏重塑及功能会议优秀青年研究学者奖

承担科研项目情况:

  • 国家自然科学基金优秀青年科学基金项目,主持
  • 国家自然科学基金面上项目,主持
  • 中国科学院A类战略性先导科技专项子课题,主持
  • 国家自然科学基金创新研究群体,骨干
  • 国家重点研发计划“主动健康和老龄化科技应对”重点专项子课题,骨干
  • 中国科学院王宽诚率先人才计划 “卢嘉锡国家团队”,骨干
  • 美国心脏协会博士后奖学金,主持
  • 美国心脏协会博士生奖学金,主持

代表论著:

  1. Li H, Wu Z, Liu X, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W, Song M*, Song Eli*, Liu GH* (* corresponding authors). ALKBH1 deficiency leads to loss of homeostasis in human diploid cells. Protein Cell, 2020. In press.
  2. Hu H#, Ji Q#, Song M#, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J (# co-first authors). ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Research, 2020. doi: 10.1093/nar/gkaa425.
  3. Zhang J, Liu GH*, Qu J*, Song M* (* corresponding authors). Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Therapy, 2020. doi: 10.1038/s41434-020-0149-5.
  4. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J* (* corresponding authors). SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell, 2020. In press.
  5. Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Izpisua Belmonte JC , Zhang W, Qu J, Liu GH (# co-first authors). Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell, 180:984-1001, 2020.
  6. Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH, Tang F, Qu J. A single-cell transcriptomic landscape of primate arterial aging. Nature Communications, 11:2202, 2020.
  7. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M&, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, Esteban CR, Chan P &, Qiao J &, Zhou Q &, Izpisua Belmonte JC , Qu J, Tang F, Liu GH (& senior authors). Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell (cover article), 180:585-600, 2020.
  8. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J, Tang F, Liu GH. Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology, 17:e3000201, 2019.
  9. Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M*, Zhang W*, Liu GH*, Qu J* (* corresponding authors). Low-dose quercetin positively regulates mouse healthspan. Protein Cell, 10:770-5, 2019.
  10. Deng L#, Ren R#, Liu Z#, Song M#, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J, Liu GH (# co-first authors). Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nature Communications, 10:3329, 2019.
  11. He X#, Song M#, Qu J, Guo Y, Cao H, Sun R, Liu GH, Shen Y, Major Program Expert Group (# co-first authors). Basic and translational aging research in China: present and future. Protein Cell, 10:476-84, 2019.
  12. Song M, Belmonte JCI, Liu GH. Age-related cardiopathies gene editing. Aging (Albany NY), 11:1327-8, 2019.
  13. Ren X#, Hu B#, Song M#, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH (# co-first authors). Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports, 26:3643-56, 2019.
  14. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W*, Song M*, Qu J*, Liu GH* (* corresponding authors). Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell, 10:649-667, 2019.
  15. Ling C#, Liu Z#, Song M#, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Belmonte JCI, Wang Z, Qu J, Yuan Y, Liu GH (# co-first authors). Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. Protein Cell. 10:249-271, 2019.
  16. Wang Y, Li Y, He C, Gou B, Song M* (* corresponding author). Mitochondrial regulation of cardiac aging. Biochimica et Biophysica Acta - Molecular Basis of Disease, 865:1853-64, 2019.
  17. Geng L#, Liu L#, Zhang W#*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH* (* corresponding authors). Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell, 10:417-35, 2019.
  18. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S, Ding J, Chan P, Zhang W&, Song M&, Belmonte JCI&, Qu J, Tang F, Liu GH (& senior authors). FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell (cover article, accompanying editorial), 24:447-61, 2019.
  19. Wang P#, Liu Z#, Zhang X#, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J* (* corresponding authors). CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-kB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell, 9:945-65, 2018.
  20. Wu Z#, Zhang W#, Song M#, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J, Suzuki K, Belmonte JCI, Liu GH. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome (# co-first authors). Protein Cell, 9:333-350, 2018.
  21. Zhang W#, Song M#, Qu J, Liu GH (# co-first authors). Epigenetic modifications in cardiovascular aging and diseases. Circulation Research, 123:773-86, 2018.
  22. Song M, Franco A, Fleischer J, Zhang L, Dorn GW II. Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial aging. Cell Metabolism (cover article), 26:872-83, 2017.
  23. Song M, Mihara K, Chen Y, Scorrano L, Dorn GW II. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metabolism (featured article), 21:273-85, 2015.
  24. Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW II (# co-first authors). Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science (accompanying editorial), 350:aad2459, 2015.
  25. Song M#, Matkovich S#, Zhang Y, Hammer D, Dorn GW II (# co-first authors). Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth. Science Signaling (cover article, Podcast interview), 8:ra39, 2015.
  26. Song M, Gong G, Burelle Y, Gustafsson ?B, Kitsis RN, Matkovich SJ, Dorn GW II. Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts. Circulation Research (featured article, accompanying editorial), 117:346-51, 2015.
  27. Song M and Dorn GW II. Mitoconfusion: Non-canonical functioning of dynamism factors in static mitochondria of the heart. Cell Metabolism, 21:195-205, 2015.
  28. Shirihai OS, Song M, Dorn GW II. How mitochondrial dynamism orchestrates mitophagy. Circulation Research, 116:1835-49, 2015.
  29. Dorn GW II, Song M, Walsh K. Functional implications of mitofusin 2-mediated mitochondrial-SR tethering. Journal of Molecular and Cellular Cardiology, 78C:123-8, 2015.
  30. Song M, Chen Y, Gong G, Murphy E, Rabinovitch P, Dorn GW II. Super-suppression of mitochondrial ROS signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circulation Research (cover article, featured article, accompanying editorial), 115:348-53, 2014.
  31. Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW II. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circulation Research, 114:257-65, 2014.

写给考生的话: