姓  名: 黄仕强
学  科: 再生医学
电话/传真: +86-10-64807768 / 
电子邮件: huangsq@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 干细胞与生殖生物学国家重点实验室 100101
更多信息: 干细胞再生与代谢研究组     

简历介绍:

  黄仕强,男,博士学位,中国科学院动物研究所的研究员,博士生导师,中国科学院大学岗位教授,干细胞再生与代谢研究组组长。
  2008年于普林斯顿大学 Princeton University 获得分子生物学理学学位(最优等荣誉)。2013年于哈佛医学院 Harvard Medical School 获得生物医学博士学位。2013年至2017年担任新加坡基因组研究所 Genome Institute of Singapore 研究组组长。他是开创干细胞代谢领域的青年研究者之一,研究重点涉及干细胞分化与再生过程中所需的代谢变化。他发现,成年哺乳类动物,包括人类体内有一种处于沉睡状态的“青春”基因 Lin28,能通过代谢调控促使多种受创细胞组织重新修复。该成果发表在 Cell(2013),被国际多家主流媒体所报道。2016年,黄仕强研究组在肌肉干细胞代谢与临床肌肉衰减症的研究中取得了突破,成果发表于 Nature Medicine,成为该期刊的封面文章,备受国际媒体关注。其他研究成果也发表在 Science、Cell、Cell Stem Cell、Cell Metabolism、Cell Reports、Genes Dev、Development等杂志上。

研究领域:

  我们的实验室正在以肌肉组织和多种动物为模型,研究肌肉再生和老化过程中的干细胞代谢。我们的愿景是将肌肉干细胞生物学的最新进展、代谢组学与深度测序的最新技术相结合,以探索如何通过调节代谢系统来调节干细胞的自我更新。这些新发现对于治疗老龄化人口中的退行性代谢性疾病,如2型糖尿病和肌肉衰减综合症,将具有重要的意义。为此,我们正在利用代谢组学技术指导我们构建肌肉干细胞模型,并诱导它们在体外分化为成熟肌原纤维。

社会任职:

获奖及荣誉:

  中国科学院杰出科技成就奖(集体主要完成者)(2020),中国科学院年度创新人物(2019),中源协和生命医学创新突破奖(2018),霍华德休斯医学院国际学者HHMI International Scholar(2017),戈登国际会议奖学金(2013),国际干细胞研究学会(ISSCR)奖学金(2012),ISSCR最佳海报奖(2011)。

承担科研项目情况:

代表论著:

  1. Le, M. T., Teh, C.*, Shyh-Chang, N.*, Xie, H., Zhou, B., Korzh, V., Lodish, H. F., and Lim, B. (2009). MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 23, 862–76.
  2. Zhu, H., Shah, S., Shyh-Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., Hirschhorn, J. N., Palmert, M. R., and Daley, G. Q. (2010). Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nature Genetics 42, 626-30.
  3. Zhu, H.*, Shyh-Chang, N.*, Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., DIAGRAM Consortium, MAGIC Investigators, Altshuler, D., and Daley GQ. (2011). The Lin28/let-7 axis regulates glucose metabolism. Cell 147, 81-94.
  4. Le, M. T.*, Shyh-Chang, N.*, Khaw, S. L., Chin, L., Teh, C., Tay, J., O'Day, E., Korzh, V., Yang, H., Lal, A., Lieberman, J., Lodish, H. F., and Lim, B. (2011). Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genetics 7, e1002242.
  5. Shyh-Chang, N., Zheng, Y., Locasale, J. W. and Cantley, L. C. (2011). Human pluripotent stem cells decouple respiration from energy production. EMBO Journal 30, 4851-4852.
  6. Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., Bhakoo, K. K., Jayapal, S. R., Nichane, M., Yu, Q., Ahmed, D. A., Tan, C., Sing, W. P., Tam, J., Thirugananam, A., Noghabi, M. S., Pang, Y. H., Ang, H. S., Mitchell, W., Robson, P., Kaldis, P., Soo, R. A., Swarup, S., Lim, E. H., and Lim, B. (2012). Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-72.
  7. Shinoda, G., Shyh-Chang, N., de Soysa, T. Y., Zhu, H., Seligson, M. T., Shah, S. P., Abo-Sido, N., Yabuuchi, A., Hagan, J. P., Gregory, R. I., Asara, J. M., Cantley, L. C., Moss, E. G., and Daley, G. Q. (2013). Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. doi: 10.1002/stem.1423.
  8. Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., Asara, J. M., Daley, G. Q., and Cantley, L. C. (2013). Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 339, 222-226.
  9. Shyh-Chang, N., Daley, G. Q., and Cantley, L. C. (2013). Stem cell metabolism during tissue development and aging. Development 12, 2535-47.
  10. Shyh-Chang, N. and Daley, G. Q. (2013). Lin28: Primal regulator of growth and metabolism in stem cells. Cell Stem Cell 12, 395-406.
  11. Shyh-Chang, N., Zhu, H., de Soysa, T. Y., Shinoda, G., Seligson, M. T., Tsanov, K. T., Nguyen L., Asara, J. M., Cantley, L. C., and Daley, G. Q. (2013). Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 155, 778-92.
  12. Shyh-Chang, N. and Daley, G. Q. (2015). Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metabolism 21, 349-50
  13. Khaw, S. L., Min-Wen, C., Koh, C. G., Lim, B., and Shyh-Chang, N. (2015). Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Reports 12(7), 1080-8.
  14. Wu, L.*, Nguyen L. H.*, Zhou, K., de Soysa, T. Y., Li, L., Miller, J. B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M. T.,  Zeitels, L. R., Acharya, A., Wang, S. C., Mendell, J. T., He, X., Nishino, J., Morrison, S. J., Siegwart, D. J., Daley, G. Q., Shyh-Chang, N., Zhu, H. (2015).  Precise let-7 expression levels balance organ regeneration against tumor suppression. eLife 10.7554
  15. Liu TM, Lee EH, Lim B, Shyh-Chang, N. (2015). Balancing Stem Cell Self-renewal and Differentiation with PLZF. Stem Cells doi: 10.1002/stem.2270.
  16. Jun-Hao ET, Gupta RR, Shyh-Chang, N. (2016). Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol. Metab. S1043-2760(15)00251-9. doi: 10.1016/j.tem.2015.12.006.
  17. Min-Wen JC, Jun-Hao ET, Shyh-Chang, N. (2016). Stem cell mitochondria during aging. Seminars in Cell and Developmental Biology. doi:10.1016/j.semcdb.2016.02.005.
  18. Tan, J.L., Fogley, R.D., Flynn, R.A., Ablain, J., Yang, S., Saint-André, V., Fan, Z.P., Do, B.T., Laga, A.C., Fujinaga, K., Santoriello, C., Greer, C.B., Kim, Y.J., Clohessy, J.G., Bothmer, A., Pandell, N., Avagyan, S., Brogie, J.E., van Rooijen, E., Hagedorn, E.J., Shyh-Chang, N., White, R.M., Price, D.H., Pandolfi, P.P., Peterlin, B.M., Zhou, Y., Kim, T.H., Asara, J.M., Chang, H.Y., Young, R.A., Zon, L.I. (2016). Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular Cell. 62(1), 34-46.
  19. Fukawa, T., Yan-Jiang, B.C., Min-Wen, J.C., Jun-Hao, E.T., Huang, D., Qian, C.N., Ong, P., Li, Z., Mohan, R.E., Wang, R.R., Kanayama, H., Lai, J.H., Chua, C., Ong, H.S., Tan, K.K., Ho, Y.S., Tan, I.B., Teh, B.T., Shyh-Chang, N. (2016). Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature Medicine. 22(6), 666-71.
  20. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. (2016). Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166, 451-467.
  21. Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. (2017). Proteomic and metabolomic characterization of a mammalian cellular transition from quiescence to proliferation. Cell Rep. 20(3), 721-736.
  22. Liu TM, Shyh-Chang N. (2017). SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 19(5), 412-414.
  23. Andriani Y#, Chua JM#, Chua BY, Phang IY, Shyh-Chang N*, Tan WS*. (2017). Polyurethane acrylates as effective substrates for sustained in vitro culture of human myotubes. Acta Biomater. 57, 115-126.
  24. Shyh-Chang N and Huck-Hui Ng. (2017). The Metabolic Programming of Stem Cells. Genes Dev. 31(4), 336-346.
  25. Min-Wen JC, Yan-Jiang BC, Mishra S, Dai X, Magae J, Shyh-Chang N, Kumar AP, Sethi G. (2017). Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Adv Protein Chem Struct Biol. 108, 199-225.
  26. Shyh-Chang N. (2017). Metabolic Changes During Cancer Cachexia Pathogenesis. Adv Exp Med Biol. 1026, 233-249.
  27. Usman WM, Pham TC, Kwok YY, Vu LT, Ma V, Peng B, Chan YS, Wei L, Chin SM, Azad A, He AB, Leung AYH, Yang M, Shyh-Chang N, Cho WC, Shi J, Le MTN. (2018). Efficient RNA drug delivery using red blood cell extracellular vesicles. Nat Commun. 9, 2359.
  28. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J. (2019). Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell. doi: 10.1007/s13238-019-0610-7
  29. Chua MJ, Yildirim ED, Tan JE, Chua YB, Low SC, Ding SLS, Li CW, Jiang Z, Teh BT, Yu K, Shyh-Chang N. (2019). Assessment of different strategies for scalable production and proliferation of human myoblasts. Cell Prolif. e12602. doi: 10.1111/cpr.12602.
  30. Li CW*, Yu K#, Shyh-Chang N#, Li GX, Jiang LJ, Yu SL, Xu LY, Liu RJ, Guo ZJ, Xie HY, Li RR, Ying J, Li K, Li DJ. (2019). Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle. doi: 10.1002/jcsm.12417.
  31. Jiang Z, Guang L, Li L, Shyh-Chang N#. (2019). Putting stem cells on a low-fat diet switches their pluripotent state. Cell Stem Cell, doi: 10.1016/j.stem.2019.06.002.
  32. Xu YJ, Liu PP, Ng SC, Teng ZQ, Liu CM. (2019). Regulatory Networks between Polycomb Complexes and Non-coding RNAs in Central Nervous System. J Mol Cell Biol, doi: 10.1093/jmcb/mjz058.
  33. Liu T, Shyh-Chang N#. (2019). Oncofetal SALL4-driven tumorigenesis is highly dependent on oxidative phosphorylation, revealing therapeutic opportunities. Gastroenterology, doi: 10.1053/j.gastro.2019.09.044.
  34. Xu C, Ooi WF, Qamra A, Tan J, Chua BY, Ho SWT, Das K, Adam Isa ZF, Li Z, Yao X, Yan T, Xing M, Huang KK, Lin JS, Nandi T, Tay ST, Lee MH, Tan ALK, Ong X, Ashktorab H, Smoot D, Li S, Ng SC, Teh BT, Tan P. (2020). HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer. Gut, doi: 10.1136/gutjnl-2018-318025.
  35. Liu TM, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N#. (2020). Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells. Stem Cell Reports, doi: 10.1016/j.stemcr.2020.01.002.
  36. Wu J, Song D, Li Z, Guo B, Xiao Y, Liu W, Liang L, Feng C, Gao T, Chen Y, Li Y, Wang Z, Wen J, Yang S, Liu P, Wang L, Wang Y, Peng L, Stacey GN, Hu Z, Feng G, Li W, Huo Y, Jin R, Shyh-Chang N, Zhou Q, Wang L, Hu B, Dai H, Hao J. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Res. 2020 Sep;30(9):794-809.
  37. Yao Z, Chen Y, Cao W, Shyh-Chang N#. Chromatin-modifying drugs and metabolites in cell fate control. Cell Prolif. 2020 Nov;53(11):e12898.
  38. Xiaoxiao Wang, Yunlong Xiang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang , Xiaoqing Wang, Xukun Lu, Dandan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh-Chang, Hongmei Wang, Naihe Jing, Wei Xie, Lei Li. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Res. 2021 Feb 19. DOI: 10.1038/s41422-021-00477-x.
  39. Chun-Wei Li*, Kang Yu*, Ng Shyh-Chang*, Guo-Xun Li, Song-Lin Yu , Hui-Jun Liu, Bo Yang, Zi-Yao Li, Yong-Jie Zhao, Long-Yu Xu, Jing Xu, Ling-Juan Jiang, Rong-Ji Liu, Xin-Yuan Zhang, Shao-Fei Li, Xiao-Wei Zhang, Hai-Yan Xie, Kang Li, Yi-Xiang Zhan, Min Cui, Hang-Bo Tao, Yao Li, Gao-Shan Liu, Ke-Min Ni, Dong-Jing Li. Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian Chinese men and women. Cell Prolif. 2021 Feb 20;e12989. DOI: 10.1111/cpr.12989
  40. Ng Shyh-Chang# and Lei Li#. Stabilizing Formative Pluripotent States with Germ Cell Competency. Cell Stem Cell. 2021 Mar; DOI: 10.1016/j.stem.2021.02.021.

写给考生的话:

  宝剑锋从磨砺出,梅花香自苦寒来。——陆游