姓  名: 王昱凯
学  科: 干细胞与神经生物学
电话/传真: +86-10-62559405 / 
电子邮件: wangyukai@ioz.ac.cn
通讯地址: 北京市海淀区北四环西路25-2,中国科学院动物研究所 国家干细胞资源库 100101
更多信息: 生殖工程研究组     

简历介绍:

  王昱凯,男,博士,副研究员,硕士生导师。

  2011年博士毕业于山东大学,随后加入中国科学院动物研究所从事博士后研究,先后担任助理研究员、副研究员。主要方向为干细胞命运调控与神经再生,重点关注帕金森病、脑血管病、阿尔兹海默病的神经修复和治疗,相关研究成果发表在Cell,Cell reports,Stem cell reports,Cell research等刊物共20余篇,授权专利2项。担任npj Regenerative Medicine,Neural Regeneration Research和Stroke & Vascular Neurology等期刊独立审稿人。

  成果包括:发现长非编码RNA调控小鼠胚胎第一次命运选择并揭示机制;建立临床级人多巴胺神经细胞制备技术;在帕金森病猴模型中证明神经替代疗法的长期安全性和有效性;合作开展细胞治疗帕金森病的临床研究;建立阿尔茨海默病和脑小血管病的细胞治疗策略等。其中1项成果入选2019年度“中国生命科学十大进展”,1项研究受Nature杂志和中央台报道,并受诺奖得主关注和引用。

研究领域:

  研究多能干细胞向特定亚型神经细胞的命运调控和定向分化技术;建立人神经类器官并将其用于疾病建模、药物筛选;开发神经细胞药物,用于重大神经系统疾病的替代治疗。

社会任职:

获奖及荣誉:

承担科研项目情况:

  国家自然基金委联合基金项目(U21A20396),2022-2025,科研骨干

  国家自然基金委面上基金项目(31970821),2020-2023,主持

  国家重点研发计划(2019YFA0903800),2020-2024,科研骨干

  国家重点研发计划(2019YFA0110800),2019-2023,科研骨干

  中国科学院战略性先导科技专项,2017-2022,科研骨干

  国家自然基金委青年科学基金项目(31601173),2017-2019,主持

代表论著:

  1. Zhao YL#, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR*, Wang YK*, Wang YL*. Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion. Cell Proliferation. 2022, Apr 19;e13223.
  2. Sun Y#, Feng L#, Liang LM#, Stacey GN, Wang CQ, Wang YK*, Hu BY*. Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment. STEM CELLS Translational Medicine. 2021; Nov;10 Suppl 2(Suppl 2):S31-S40.
  3. Liu J#, Hou ZR#, Wu J#, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK*, Hao J*, Hu BY*. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation. 2021; Aug;54(8):e13085.
  4. Wang YK#, Zhu WW#, Wu MH#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports, 2018, 11(1): 171-182
  5. Wang JQ#, Wang LY#, Feng GH#, Wang YK#, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Cell, 2018, 175(7): 1887-1901
  6. He ZQ#, Xia BL#, Wang YK#, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K, Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q, Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening, Cell Reports, 2017, 20(9): 2227-2237
  7. Lu XY#Wang YK#, Yan L, Wang LB, Li W, Wang HM, Variations in mesenchymal-epithelial transition-related transcription factors during reprogramming of somatic cells from different germ layers into iPSCs, Journal of Genetics and Genomics, 2016, 43(10): 609-612
  8. Li X#, Cu XLi#, Wang JQ#Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q, Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells, Cell, 2016, 164(1-2): 279-292
  9. Li ZK#, Wang LB#, Wang YK#, Liu L, Wang L, Li W, Zhou Q, Generation of an LncRNA Gtl2-GFP Reporter for Rapid Assessment of Pluripotency in Mouse Induced Pluripotent Stem Cells, Journal of Genetics and Genomics, 2015, 42(3): 125-128
  10. Shuai L#, Wang YK#, Dong MZ#, Wang XP#, Sang LS, Wang M, Wan HF, Luo GZ, Gu TT, Yuan Y, Feng CJ, Teng F, Li W, Liu XY, Li TD, Wang L, Wang XJ, Zhao XY, Zhou Q, Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro, J Mol Cell Biol, 2015, 7(4): 326-337
  11. Wang LB#, Cao JN#Wang YK#, Lan TS#, Liu L, Wang WX, Jin N, Gong JQ, Zhang C, Teng F, Yan GL, Li C, Li JL, Wan HF, Hu BY, Li W, Zhao XY, Qi ZQ, Zhao TB, Zhou Q, Immunogenicity and functional evaluation of iPSC-derived organs for transplantation, Cell Discovery, 2015, 7;1:15015
  12. Wang YK#, Zhao GY#, Li Y, Chen XL, Xie BB, Su HN, Lv YH, He HL, Liu H, Hu J, Zhou BC, Zhang YZ, Mechanistic insight into the function of the C-terminal PKD domain of the collagenolytic serine protease deseasin MCP-01 from deep sea Pseudoalteromonas sp. SM9913: binding of the PKD domain to collagen results in collagen swelling but does not unwind the collagen triple helix, J Biol Chem, 2010, 285(19): 14285-14291
  13. Wang YK#, He HL, Wang GF, Wu H, Zhou BC, Chen XL, Zhang YZ, Oyster (Crassostrea gigas) hydrolysates produced on a plant scale have antitumor activity and immunostimulating effects in BALB/c mice, Marine Drugs, 2010, 8(2): 255-268  
  14. Wang YK#, He HL, Chen XL, Sun CY, Zhang YZ, Zhou BC, Production of novel angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM 605, Appl Microbiol Biotechnol, 2008, 79(5): 785-791

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