姓  名: 王关红
学  科: 基因组学/动物学
电话/传真: +86-10-64807185 / 
电子邮件: ghwang@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号中国科学院动物研究所 100101
更多信息: 昆虫微生物组学与应用研究组     

简历介绍:

  王关红,男,博士,博士生导师,昆虫微生物组学与应用研究组组长。

  2021.2 至今 研究组长,中国科学院动物研究所

  2019 - 2021 博士后,加州大学圣地亚哥分校

  2016 - 2019 博士后,哈佛大学

  2015 - 2016 联合培养博士,耶鲁大学

  2011 - 2015 博士,中国科学院动物研究所

研究领域:

  昆虫学,微生物学,基因工程,基因组学。

  研究方向

  全球半数的人群都面临着因蚊虫叮咬而导致的疾病传播风险,近年来城镇化、全球贸易、气候变暖和土地使用变更等问题诱发的蚊虫跨区域传播,也加剧了虫媒传染病的再次发生和扩张。例如登革热在过去50年感染人群数量增长超过30倍,每年全球约有4亿人感染登革热,造成400亿的经济损失。防控蚊虫等媒介生物是减少人类感染虫媒病原菌最高效、成本最低的方法之一。本研究组以基因组学为主要手段,基于多组学,基因编辑,微生物分离筛选,无菌体系等方法,探索微生物与宿主互作以及微生物和基因编辑技术对蚊虫进行防控。

  1. 基于微生物和基因编辑/驱动防控蚊虫新技术

  围绕微生物和基因编辑开发新型的经济,可持续,环境友好的蚊虫防控新技术。

  2. 微生物功能挖掘

  以模式生物寄生蜂和蚊虫为研究对象,深度挖掘微生物在宿主适应性进化,抗药性演化等方面起的作用,开发有益菌或者工程菌。

  3. 微生物群落结构调控

  利用宏基因组、代谢组、基因编辑和寄生蜂无菌体系等手段,重点研究宿主调控微生物群落结构的分子和生理机制,为利用微生物手段来对病害和害虫进行绿色防控提供理论依据。

社会任职:

获奖及荣誉:

承担科研项目情况:

代表论著:

  (#共同第一作者,*通讯作者)

  12.Wang, G.-H.#, Stephanie Gamez#, Robyn Raban, John Marshall, Luke Alphey, Ming Li, Jason Rasgon, Omar S. Akbari*. 2021. Combating mosquito-borne pathogens using genetic control technologies. Nature Communications12 , 4388.

  11. Wang G-H, Dittmer J, Douglas B, Huang L, Brucker RM*. 2021. Coadaptation between host genome and microbiome under long-term xenobiotic-induced selection. Science Advances 7, eabd4473.

  10. Wang, G.-H., B. M. Berdy, O. Velasquez, N. Jovanovic, S. Alkhalifa, K. P. C. Minbiole, and R. M. Brucker. 2020. Changes in Microbiome Confer Multigenerational Host Resistance after Sub-toxic Pesticide Exposure.Cell Host & Microbe 27:213-224.e217.

  9. Robert M. Brucker and Guan-Hong Wang (2019) “Bacterial Probiotic to Detoxify Herbicides and Insecticides” (U.S. Provisional Application No.: US 2019/0321417 A1). Equal inventorship.

  8. Wang, G.-H., and R. M. Brucker*. 2019a. Genome sequence of Enterococcus faecalis NVIT04, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01156-01118.

  7. Wang, G.-H., and R. M. Brucker*. 2019b. Genome sequence of Providencia rettgeri NVIT03, isolated from Nasonia vitripennis. Microbiology Resource Announcements 8:e01157-01118.

  6. Huan Li, Tongtong Li, Xiangzhen Li*, Guanhong Wang, Qiang Lin and Jiapeng Qu*. 2018. Gut microbiota in Tibetan herdsmen reflects the degree of urbanization. Frontiers in Microbiology 9:1745.

  5. Guan-Hong Wang*, Bao-Fa Sun, Tuan-Lin Xiong, Yan-Kun Wang, Jin-Hua Xiao*, Da-Wei Huang*. 2016. Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes. Frontiers in Microbiology 7:1867. (*co-corresponding)

  4. Guan-Hong Wang, Ling-Yi Jia, Jin-Hua Xiao*, Da-Wei Huang*. 2016. Discovery of a novel Wolbachia supergroup in cave spider species and the lateral transfer of phage WO among distant hosts. Infection, Genetics and Evolution 41 (2016) 1–7.

  3. Guan-Hong Wang, Jin-Hua Xiao*, Li-Ming Niu, Guang-Chang Ma, and Da-Wei Huang*. 2014. Large proportion of genes in a cryptic WO prophage genome are actively transcribing in an insect species with sex-specific patterns: involvement in Wolbachia biology and reproductive manipulation? BMC Genomics 15:893.

  2. G.-H. Wang, J.-H. Xiao*, T.-L. Xiong, Z. Li, R. W. Murphy, and D.-W. Huang*. 2013. High-Efficiency Thermal Asymmetric Interlaced PCR (hiTAIL-PCR) for determination of a highly degenerated prophage WO genome in a Wolbachia strain infecting a fig wasp species. Applied and Environmental Microbiology 79:7476-7481.

  1. Xiao, Jin-Hua#; Yue, Zhen#; Jia, Ling-Yi#; Yang, Xin-Hua#; Niu, Li-Hua#; Wang, Zhuo#; Zhang, Peng#; Sun, Bao-Fa; He, Shun-Min; …; Wang, Guan-Hong; Yu, Hui; Wu, Wen-Shan; Cook, James M.*; Wang, Jun*; Huang, Da-Wei*. 2013. Obligate mutualism within a host drives the extreme specialization of a fig wasp genome. Genome Biology 14:R141.

写给考生的话:

  越努力,越幸运。