姓  名: 于乐谦
学  科: 再生医学
电话/传真: +86-10-64807235 / 
电子邮件: leqianyu@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 干细胞与生殖生物学国家重点实验室 100101
更多信息: 干细胞与发育体外模拟研究组     

简历介绍:

  于乐谦,研究员,博士生导师。2017年博士毕业于日本国立京都大学(日本国费留学生),随后于美国得克萨斯大学西南医学中心从事博士后研究工作。2022年8月全职加入中国科学院动物研究所。主要从事多能干细胞(包括胚胎干细胞和诱导多能性干细胞)的基础研究和转化应用。建立、鉴定、研究及利用不同物种,不同多能态(原始态、形成态、始发态),以及胚胎干细胞与胚胎外干细胞(包括滋养层细胞和胚外内胚层细胞)细胞系;结合微流控等技术研究多能干细胞与细胞外微环境的关系;利用多能性干细胞构建体外早期胚胎发育模型等。近五年以第一作者身份在Nature,Cell Stem Cell,Cell Discovery,Stem Cell Reports等杂志发表论文共6篇。以共同作者身份在Nature,Cell,Nature Genetics,Communications biology,Reproduction,Stem Cell Reports,Stem Cell Research & Therapy等杂志发表论文若干,并取得2项国际专利。2021年入选MIT科技评论中国“35岁以下科技创新35人”。代表性工作包括体外构建首个人类胚胎完整模型“类囊胚”,为研究人类早期胚胎发育打开了一扇新的大门。该工作以封面文章形式发表于Nature杂志,全世界600多家科技及大众媒体包括Nature News、Science News,我国新华网,美国NPR News、US News、New York Times、NBC News,日本NHK新闻、朝日新闻等皆对该项工作进行了报道。该工作同时入选Science杂志“2021年度科技十大突破进展”以及我国两院院士评选“2021年中国/世界十大科技进展新闻”

研究领域:

  1. 基于人类多能干细胞构建人类早期胚胎发育、器官形成及疾病模型

  2. 结合多能干细胞与微流控芯片技术研究人类早期胚胎发育关键事件

  3. 不同物种诱导多能性干细胞的构建与应用

社会任职:

获奖及荣誉:

承担科研项目情况:

代表论著:

  1. Yu, L. #; Wei, Y. #; Duan, J. #; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.*; Wu, J.*, Blastocyst-like structures generated from human pluripotent stem cells, Nature, 2021 (# Co-frist authors)
  • 该工作入选Science杂志评选“Sicence 2021年科学10大突破进展”
  • 该工作入选我国两院院士评选“2021年中国/世界十大科技进展新闻”
  • 该工作被Natrue杂志(Vol 591, Issue 7851)选为当期封面故事
  • 当期Nature杂志评论该工作“First complete model of the human embryo”
  • Nature新闻评论该工作“Lab-grown structures mimic human embryo's earliest stage yet”
  • Science新闻评论该工作 “Researchers re-create key human embryo stage in lab”
  • 该工作同时被世界范围600多家媒体机构报道,包括 Xinhua News, NPR News, US News, New York Times, NHK News, Asahi News, NBC News
  1. Liu, T. #; Li, J. #; Yu, L. #; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.*; Gu, Y.*, Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Cell discovery, 2021 (# Co-frist authors)
  2. Zheng, C. #; Hu, Y. #; Sakurai, M. #; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J.*, Cell competition constitutes a barrier for interspecies chimerism, Nature, 2021
  3. Yu, L. #; Wei, Y. #; Sun, H. #; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J.*, Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Cell Stem Cell, 2020 (# Co-frist authors)
  • Cell Stem Cell杂志评论该工作“Stabilizing Formative Pluripotent States with Germ Cell Competency
  • ScienceDaily New评论该工作 “Development of new stem cell type may lead to advances in regenerative medicine”
  • GEN News评论该工作“New Stem Cell Derived from Mice, Horses, and Humans”
  1. Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J.*, Derivation of sheep embryonic stem cells under optimized conditions. Reproduction, 2020
  2. Li, J. #; Zhang, L. #; Yu, L.; Minami, I.; Miyagawa, S.; Horning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.*; Tang, C.*; Liu, L.*, Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Communications biology, 2020
  3. Yu, L. #; Li, J. #; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L.*, Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation. Advanced Healthcare Materials, 2019 (# Co-frist authors)
  • 该工作被Advanced Healthcare Materials杂志选为当期封面故事
  1. Li, R. #; Zhong, C. #; Yu, Y. #; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nunez-Delicado, E.; Rodriguez Esteban, C.; Wu, J. *; Izpisua Belmonte, J. C.*; Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell, 2019
  2. Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.*; Ren B*. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nature Genetics, 2019
  3. Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.*; Wei, H. *; Han, J*. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Research & Therapy, 2019
  4. Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.*; Kotera, H.*; Liu, L.*, Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells. Stem Cell Reports, 2018
  5. Li, J. #; Minami, I. #; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium. Stem Cell Reports, 2017
  6. Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.* and Chen, Y. * , Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, J. Mater. Chem. B, 2017
  7. Li, X.#; Yu, L.#; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.*; Chen, Y.*, On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Biofabrication, 2016. (# Co-frist authors)
  8. Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y.*, Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers. Nanoscale, 2016
  9. Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.*; Chen, Y.*, Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem cells international, 2016
  10. Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y.*, Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers. Journal of Materials Chemistry B, 2016

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