金坚石，博士，研究员，博士生导师；中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室金坚石研究组组长。

　　2009年获得南京大学学士学位，2014年获得北京大学博士学位。2010-2011前往哈佛大学访问学习。2014-2016年在北京大学生命科学学院从事博士后研究。2016-2023年在日本理化学研究所先后担任JSPS访问研究员、Research Scientist、Senior Scientist。

　　主要从事单细胞测序、显微成像和智能化系统等的研发工作，同时也研究肠道菌群和转录调控等复杂系统相关的生物学问题。研究成果发表于Science，Nature Communications, Science Immunology，PNAS，The Journal of Immunology等杂志。

　　近年来，动物肠道菌群研究提示菌群可影响宿主的行为、繁殖、代谢、疾病或衰老等。这些研究充分预示了肠道菌群对动物表型的调控潜能，这为利用菌群预测或控制有害动物爆发提供了新思路。本课题组将通过研发和应用单细胞分析技术，研究重要的农业和卫生有害哺乳动物（如害鼠）的肠道菌群功能以及菌群-宿主的互作机制，探索通过菌群调控动物表型的新策略。

　　日本学术振兴会启动专项基金，主持，2016-2017

　　日本学术振兴会外国人特别研究员奖励基金，主持，2017-2019

　　日本理化学研究所奖励研究基金，主持，2020-2022

　　日本理化学研究所-大阪大学技术合作研究基金，主持，2021-2022

　　（* 共同第一作者）：

　　14. Jianshi Jin*, Taisaku Ogawa*, Nozomi Hojo, Kirill Kryukov, Kenji Shimizu, Tomokatsu Ikawa, Tadashi Imanishi, Taku Okazaki, Katsuyuki Shiroguchi, Robotic data acquisition with deep learning enables cell image-based prediction of transcriptomic states. Proceedings of the National Academy of Sciences USA, 120 (1), e2210283120, 2023.

　　13. Jianshi Jin, Reiko Yamamoto, Tadashi Takeuchi, Guangwei Cui, Eiji Miyauchi, Nozomi Hojo, Koichi Ikuta, Hiroshi Ohno, Katsuyuki Shiroguchi, High-throughput identification and quantification of single bacterial cells in the microbiota. Nature communications, 13:863, 2022.

　　12. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, et al. A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Science Immunology, 7, eabj8760, 2022.

　　11. Yanmeng Li, Jianshi Jin, Fan Bai, Cancer biology deciphered by single-cell transcriptomic sequencing, Protein Cell, 13(3):167–179, 2022.

　　10. Katsuyuki Shiroguchi *, Jianshi Jin*, and Reiko Yamamoto, Method for treating cell population and method for analyzing genes included in cell population. Application No.: PCT/JP2021/020338.

　　9. Jianli Tao*, Xiao-Wei Zhang*, Jianshi Jin*, Xiao-Xia Du, Tengfei Lian, Jing Yang, Xiang Zhou, Zhengfan Jiang and Xiao-Dong Su, Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation. The Journal of Immunology, 198(9):3627-3636, 2017.

　　8. Jianshi Jin*, Tengfei, Lian*, Chan Gu*, Kai Yu, Yi Qin Gao & Xiao-Dong Su, The effects of cytosine methylation on general transcriptional factors. Scientific Reports, 6:29119, 2016.

　　7. Rong Gao, Kai Yu, Jukui Nie, Tengfei Lian, Jianshi Jin, Anders Liljas & Xiao-Dong Su, Deep sequencing reveals global patterns of mRNA recruitment during translation initiation, Scientific Reports, 6:30170, 2016.

　　6. Jianshi Jin, Tengfei, Lian, X. Sunney Xie, Xiao-Dong Su, High-accuracy mapping protein binding stability on nucleosomal DNA using single-molecule method. Journal of Molecular Cell Biology, 6(5):438-40, 2014.

　　5. Sangjin Kim,* Erik Brostromer,* Dong Xing,* Jianshi Jin,* Shasha Chong, Hao Ge, Siyuan Wang, Chan Gu, Lijiang Yang, Yi Qin Gao, Xiao-dong Su, Yujie Sun, X. Sunney Xie, “Probing Allostery Through DNA.” Science, 339:816-819, 2013.

　　4. Fan Bai, Zhanghan Wu, Jianshi Jin, Philip Hochendoner, Jianhua Xing, Slow protein conformational change, allostery and network dynamics, Protein-Protein Interactions-Computational and Experimental Tools, Dr. Weibo Cai (Ed.), ISBN: 978-953-51-0397-4, In Tech. 2012.

　　3. 苏晓东, 金坚石, 谢晓亮. 单分子水平的酶催化与基因表达研究. 物理化学学报, 26(7): 1976-87, 2010.

　　2. Juan Zhao, Jianshi Jin, Chunhui Wu, Hui Jiang, Yanyan Zhou, Jinglin Zuo, Xuemei Wang, “Highly sensitive identification of cancer cells by combining the new tetrathiafulvalene derivative with a β-cyclodextrin/multi-walled carbon nanotubes modified GCE.” Analyst, 135(11):2965-2969, 2010.

　　1. Ya Chen, Wei Liu, Jian-Shi Jin, Bin Liu, Zhi-Gang Zou, Jing-Lin Zuo, Xiao-Zeng You, “Rhenium(I) tricarbonyl complexes with bispyridine ligands attached to sulfur-rich core: Syntheses, structures and properties.” Journal of Organometallic Chemistry, 694(5):763-770, 2009.

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