姓  名: 王 明
学  科: 基因组学/表观遗传学/植物保护学
电话/传真:  / 
电子邮件: wangming@ioz.ac.cn
通讯地址: 北京市朝阳区北辰西路1号院5号
中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室 100101
更多信息: 王明研究组     

简历介绍:

  王明,博士,研究员,博士生导师;中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室王明研究组组长。 2010年本科毕业于中国农业大学生物学院,2015年于加州大学河滨分校植物病理与微生物系获得博士学位,2015-2017期间在加州大学河滨分校进行博士后研究,并于2017年9月起在加州大学洛杉矶分校先后担任博士后与副项目科学家。2023年6月起任中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室研究组组长。

  主要从事小RNA等表观遗传信号在植物与病害间的跨界传递与调控,以及利用表观遗传编辑技术与CRISPR-dCAS9系统调控植物基因表达。研究成果以第一作者(含共同)身份在ScienceNature Plants (2016, 2023), Nature Communications (2022, 2023, 2023)等杂志发表,总引用超过3000次(Google Scholar),并取得美国专利1项。

研究领域:

  研究组主要从事植物保护和表观遗传学研究,通过基因组学,分子生物学,表观遗传学、生物信息学等方法,探究作物-病毒-虫媒三者互作过程中的信号传递与基因调控机理,揭示病害致病,虫媒传病以及植物抗病的机制,并通过表观遗传编辑技术提高作物的抗病虫害能力,为保障我国主要作物的产量与质量提供理论基础和技术支持。

社会任职:

获奖及荣誉:

承担科研项目情况:

代表论著:

(* 共同第一作者):

  1. Ming Wang*, Zhenhui Zhong*, Javier Gallego-Bartolomé, Zheng Li, Suhua Feng, Hsuan Yu Kuo, Ryan L Kan, Hoiyan Lam, John Curtis Richey, Linli Tang, Jessica Zhou, Mukun Liu, Yasaman Jami-Alahmadi, James Wohlschlegel, Steven E Jacobsen, A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis." Nature Plants (2023): 1-13.
  2. Ming Wang*, Zhenhui Zhong*, Javier Gallego-Bartolome, Suhua Feng, Yuan-Hsin Shih, Mukun Liu, Jessica Zhou, John Curtis Richey, Charmaine Ng, Yasaman Jami-Alahmadi, James Wohlschlegel, Keqiang Wu, Steven E Jacobsen. “Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14.” Nature Communications 14, 1736 (2023) 
  3. Arne Weiberg*, Ming Wang*, Feng-Mao Lin, Hongwei Zhao, Zhihong Zhang, Isgouhi Kaloshian, Hsien-Da Huang, Hailing Jin, Fungal small RNAs suppress plant immunity by hijacking host RNA interference pathways. Science 342, 118–123 (2013)
  4. Ming Wang, Arne Weiberg, Feng-Mao Lin, Bart P. H. J. Thomma, Hsien-Da Huang, Hailing Jin. Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection. Nature Plants 2, 16151 (2016).
  5. Zheng Li*, Ming Wang*, Zhenhui Zhong*, Javier Gallego-Bartolomé, Suhua Feng, Yasaman Jami-Alahmadi, Xinyi Wang, James Wohlschlegel, Sylvain Bischof, Jeffrey A. Long, Steven E. Jacobsen. “The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.” Nature Communications 14, 4135 (2023).
  6. Zhenhui Zhong*, Yafei Wang*, Ming Wang*, Fan Yang, Quentin Angelo Thomas, Yan Xue, Yaxin Zhang, Wanlu Liu, Yasaman Jami-Alahmadi, Linhao Xu, Suhua Feng, Sebastian Marquardt, James A Wohlschlegel, Israel Ausin, Steven E Jacobsen. "Histone chaperone ASF1 mediates H3. 3-H4 deposition in Arabidopsis." Nature Communications 13, no. 1 (2022): 6970.
  7. Ming Wang, Hailing Jin. Spray-Induced Gene Silencing: a Powerful Innovative Strategy for Crop Protection. Trends in microbiology 25: 4-6 (2017).
  8. Ming Wang*, Arne Weiberg*, Exequiel Dellota Jr, Daniel Yamane, Hailing Jin. Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi. RNA Biology, 2017, 14:421-428.
  9. Ming Wang, Nicholas Thomas and Hailing Jin. Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection. Current Opinion in Plant Biology, 38:133-141, 2017.
  10. Ming Wang*, Arne Weiberg*, Hailing Jin. Pathogen small RNAs: a new class of effectors for pathogen attacks. Molecular plant pathology 16.3 (2015): 219-223.
  11. Gardiner, Jason*, Basudev Ghoshal*, Ming Wang*, and Steven E. Jacobsen. "CRISPR-CAS mediated transcriptional control and epi-mutagenesis." Plant Physiology (2022)
  12. Cai, Qiang, Lulu Qiao, Ming Wang, Baoye He, Feng-Mao Lin, Jared Palmquist, Sienna-Da Huang, and Hailing Jin. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science 360, no. 6393 (2018): 1126-1129.
  13. Zhenhui Zhong, Yan Xue, C Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman Jami-Alahmadi, Suhua Feng, James A Wohlschlegel, Steven E Jacobsen. "MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions." Genome Biology 24, no. 1 (2023): 96.
  14. Liu, Wanlu, Javier Gallego-Bartolomé, Yuxing Zhou, Zhenhui Zhong, Ming Wang, Somsakul Pop Wongpalee, Jason Gardiner, Suhua Feng, Peggy Hsuanyu Kuo, and Steven E. Jacobsen. Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase. Nature communications 12, no. 1 (2021): 1-14.
  15. Xue, Yan, Zhenhui Zhong, C. Jake Harris, Javier Gallego-Bartolomé, Ming Wang, Colette Picard, Xueshi Cao et al. Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. Nature communications 12, no. 1 (2021): 1-13.
  16. Weiberg, Arne, Ming Wang, Marschal Bellinger, and Hailing Jin. Small RNAs: A New Paradigm in Plant-Microbe Interactions. Annual Review of Phytopathology 52, no. 1 (2014).
  17. Feng, Suhua, Zhenhui Zhong, Ming Wang, and Steven E. Jacobsen. Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing. Epigenetics & chromatin 13, no. 1 (2020): 1-17.
  18. Dong, Oliver X., Louis-Valentin Meteignier, Melodie B. Plourde, Bulbul Md Ahmed, Ming Wang, Cassandra Jensen, Hainling Jin, Peter Moffett, Xin Li, and Hugo Germain. Arabidopsis TAF15b localizes to RNA processing bodies and contributes to snc1-mediated autoimmunity. Molecular Plant-Microbe Interactions 29.4 (2016): 247-257.
  19. Hamby, Rachael, Ming Wang, Lulu Qiao, and Hailing Jin. Synthesizing Fluorescently Labeled dsRNAs and sRNAs to Visualize Fungal RNA Uptake. RNA Tagging, pp. 215-225. Humana, New York, NY, 2020.

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