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姓  名:
邱星辉
学  科:
生物化学与分子生物学
电话/传真:
+86-10-64807231 / +86-10-64807099
电子邮件:
qiuxh@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 100101
更多信息:
昆虫毒理学与生物技术研究组     
简历:

  邱星辉,男,理学博士,研究员,昆虫毒理学与生物技术研究组组长。
  分别于1991年、1998年在中国科学院获生态学硕士和动物学 (昆虫毒理学方向)博士学位。现为农业虫害鼠害综合治理研究国家重点实验室研究员,昆虫毒理学与生物技术研究组组长,兼任卫生部病媒生物控制专业委员会委 员、北京市爱卫会专家委员会委员、中国昆虫学会常务理事。2001年2月-2002年5月澳大利亚联邦科学与工业研究组织(CSIRO)生物技术项目访问 学者, 2007年1月-2008年1月美国Purdue University基因组学实验室访问学者。至今在国内外发表论文篇近百篇(其中SCI论文35篇),专著1部,授权国家发明专利4项。曾于1997年获 中国科学院自然科学奖一等奖,1999年获国家自然科学奖三等奖。

研究领域:

  该实验室的目标是运用基因组学、生物化学、毒理学和分子生物学技术,解决重要农业、环境与食品安全领域的基础科学问题和实际问题。近年来的研究工作主要集中在以下几个方面:(1)细胞色素P450酶系的功能与调控;(2)有毒物质的生物转化,重点在外源有害物质的生物降解途径分析和降解酶基因的分离、表达与调控研究;(3)昆虫毒理基因组学,在基因组尺度上研究杀虫剂毒性和昆虫抗药性的分子机制。

社会任职:
获奖及荣誉:
承担科研项目情况:

  研究工作得到国家重点基础研究计划(973)、国家自然科学基金面上项目和中国科学院创新方向项目的资助。

代表论著:
  1. Feng X, Yang C, Yang Y, Jun Li, Lin K, Li M, Qiu X*, 2015. Distribution and frequency of G119S mutation in ace-1 gene within Anopheles sinensis populations from Guangxi, China. Malaria Journal,14:470
  2. Liu D, Yuan Y, Li M, Qiu X*, 2015 Effects of dietary quercetin on performance and cytochrome P450 expression of the cotton bollworm, Helicoverpa armigera. Bulletin of Entomological Research, 105 (06): 771-777
  3. Sun W, Valero MC, Seong KM, Steele LD, Huang IT, Lee CH, Clark JM, Qiu X and Pittendrigh BR, 2015. A glycine insertion in the estrogen-related receptor (ERR) is associated with enhanced expression of three cytochrome P450 genes in transgenic Drosophila melanogaster. PLoS ONE, 10(3): e0118779
  4. Liu D, Zhou X, Li M, Zhu S, Qiu X*, 2014. Characterization of NADPH-cytochrome P450 reductase gene from the cotton bollworm, Helicoverpa armigera. Gene, 545: 262-270.
  5. Wan H, Liu Y, Li M, Zhu S, Li X, Pittendrigh BR, Qiu X*, 2014. Nrf2/Maf binding site-containing functional Cyp6a2 allele is associated with DDT resistance in Drosophila melanogaster. Pest Management Science, 70: 1048-1058.
  6. Zhou X, Qian K,Tong Y, Zhu JJ, Qiu X*, Zeng X*, 2014, De novo transcriptome of the hemimetabolous German cockroach (Blattella germanica). PLoS ONE, 9(9): e106932
  7. Yan Y, Zhou X, Yang J. Li M. Qiu X*, 2013. T-2 toxin is hydroxylated by chicken CYP3A37. Food and Chemical Toxicology,62: 622-627.
  8. Yang J, An J, Li M, Hou X, Qiu X*, 2013. Characterization of chicken cytochrome P450 1A4 and 1A5: Inter-paralog comparisons of substrate preference and inhibitor selectivity. Comparative Biochemistry and Physiology, Part C 157: 337–343.
  9. Yang J, Liu Z, Li M, Qiu X*, 2013. Hydroxylation of quinocetone and carbadox is mediated by CYP1As in the chicken (Gallus gallus). Comparative Biochemistry and Physiology, Part C 158:84-90.
  10. Qiu X, Sun W, McDonnell C, Li H, Steele LD, Wu J, Xie J, Muir W, Pittendrigh. BR. 2013. Genome-wide analysis of genes associated with moderate and high DDT resistance in Drosophila melanogaster. Pest Management Science, 69:930-937.
  11. Rinkevich FD, Hedtke SH, Leichter CA, Harris SA, Su C, Brady SG, Taskin V, Qiu X, Scott JG, 2012. Multiple Origins of kdr-type Resistance in the House Fly, Musca domestica. Plos One, 7(12): e52761.
  12. Gao Q, Li M, Sheng C, Scott JG, Qiu X*, 2012. Multiple cytochrome P450s overexpressed in pyrethroid resistant house flies (Musca domestica). Pesticide Biochemistry and Physiology, 104: 252-260.
  13. Qiu X*, Pan J, Li M, Li Y, 2012. PCR-RFLP methods for detection of insecticide resistance-associated mutations in the house fly (Musca domestica). Pesticide Biochemistry and Physiology, 104 : 201–205.
  14. Wang Q, Li M, Pan J, Di M, Liu Q,Meng F,Scott JG, Qiu X*, 2012. Diversity and frequencies of genetic mutations involved in insecticide resistance in field populations of the house fly (Musca domestica L.) from China. Pesticide Biochemistry and Physiology, 102:153-159.
  15. Zhou X, Li M , Sheng C, Qiu X*, 2011. NADPH-cytochrome P450 oxidoreductase from the chicken (Gallus gallus): sequence characterization, functional expression and kinetic study.  Comparative Biochemistry and Physiology, Part C, 153: 53-59.
  16. Wang D, Qiu X, Wang H, Qiao K, Wang K, 2010. Reduced fitness associated with spinosad resistance in Helicoverpa armigera. Phytoparasitica, 38:103–110.
  17. Zhou X, Sheng C, Li M, Wan H, Liu D, Qiu X*, 2010. Expression responses of nine cytochrome P450 genes to xenobiotics in the cotton bollworm Helicoverpa armigera, Pesticide Biochemistry and Physiology, 97:209-213.
  18. Zhou X, Ma C, Sheng C, Liu H, Gong P, Qiu X*, 2010. CYP9A12 and CYP9A17 in the cotton bollworm, Helicoverpa armigera: sequence similarity, expression profile and xenobiotic response. Pest Management Science, 66: 65-73.
  19. Qiu X *, Wu P, Zhang H, Li M, Yan Z, 2009. Isolation and characterization of Arthrobacter sp. HY2 capable of degrading a high concentration of p-nitrophenol. Bioresource Technology, 100: 5243-5248.
  20. Wang D, Qiu X*, Ren X, Zhang W, Wang K*,2009. Effects of spinosad on Helicoverpa armigera (Lepidoptera: Noctuidae) from China: tolerance status, synergism and enzymatic responses. Pest Management Science, 65:1040-1046.
  21. Wang D. Qiu X. Ren X, Niu F, Wang K*, 2009. Resistance selection and biochemical characterization of spinosad resistance in Helicoverpa armigera (Hubner) (Lepidoptera:Noctuidae).  Pesticide Biochemistry and Physiology, 95:90-94.
  22. Wang D, Gong P, Li M, Qiu X*, Wang K*, 2009,Sublethal effects of spinosad on survival, growth and reproduction of Helicoverpa armigera (Lepidoptera: Noctuidae). Pest Management Science, 65(2):223-227.
  23. Xu J, Yang M, Dai J, Cao H, Pan C, Qiu X*, Xu M, 2008. Degradation of acetochlor by four microbial communities.  Bioresource Technology, 99: 7797–7802.
  24. Qiu X*, Li M, Luo H, Fu T., 2007. Molecular analysis of resistance in a deltamethrin-resistant strain of Musca domestica from China. Pesticide Biochemistry and Physiology, 89(2):146-150.
  25. Zhong Q, Zhang H, Bai W, Li M, Li B, Qiu X*, 2007. Degradation of aromatic compounds and degradation pathway of 4-nitrocatechol by Ochrobactrum sp. B2. Journal of Environmental Science and Health, Part A 42: 2111-2116. 
  26. Qiu X*, Zhong Q, Li M, Bai W, Li B, 2007. Biodegradation of p-nitrophenol by methyl parathion-degrading Ochrobactrum sp. B2.  International Biodeterioration & Biodegradation, 59 (4): 297-301.
  27. Qiu X*, Bai W, Zhong Q, Li M, He F, Li B, 2006. Isolation and characterization of a bacterial strain of the genus Ochrobactrum with methyl parathion mineralizing activity. Journal of Applied Microbiology, 101: 986-994.
  28. Horne I, Qiu X, Ollis DL, Russell RJ, Oakeshott JG, 2006. Functional effects of amino acid substitutions within the large binding pocket of the phosphotriesterase OpdA from Agrobacterium sp. P230. FEMS Microbiology Letters, 259: 187-194. 
  29. Xu J, Qiu X, Dai J, Cao H, Yang M, Zhang J, Xu M.,2006, Isolation and characterization of a Pseudomonas oleovorans degrading the choloracetamide herbicide acetochlor. Biodegradation, 17: 219-225.
  30. Qiu X, Li W, Tian Y, Leng X, 2003. Cytochrome P450 monooxygenase in the cotton bollworn(Lepidoptera: Noctuidae): tissue difference and induction. Journal of Econonic Entomology, 96(4): 1283-128.
  31. 邱星辉 2014 细胞色素P450介导的昆虫抗药性的分子机制 昆虫学报 57:477-482
  32. 邱星辉, 2005. 杀虫剂抗性:遗传学、基因组学及应用启示  昆虫学报 48(6):960-967
  33. 冷欣夫 邱星辉 2001 细胞色素P450的结构、功能与应用前景 科学出版社
写给考生的话:

  在科学上没有平坦的大道,只有不畏劳苦,沿着陡峭山路攀登的人,才有希望达到光辉的顶点。