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姓  名:
邹 振
学  科:
基因组学
电话/传真:
+86-10-64807190 / +86-10-64807099
电子邮件:
zouzhen@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 农业虫害鼠害综合治理研究国家重点实验室 100101
更多信息:
昆虫免疫和发育研究组     
简历:

  邹振,男,博士,研究员,博士生导师;中国科学院动物研究所昆虫免疫和发育研究组课题组组长。
  1997年毕业于华东理工大学获得生物化学工程学士学位,2005年于美国俄克拉荷马州立大学获得昆虫学博士学位。其后分别在俄克拉荷马州立大学和加州大学河滨分校进行博士后研究,于2010.10起担任助理研究员(Assistant Researcher)。2012年7月,任中国科学院动物研究所昆虫免疫和发育学研究组组长,研究员,博士生导师,并入选青年千人计划、百人计划。现任中国昆虫学会昆虫发育与遗传专业委员会、昆虫基因组学专业委员会委员、北京市昆虫学会常务理事、昆虫学报编委、中国媒介生物学及控制杂志编委。
  主要从事分子生物学和媒介生物学的研究,聚焦于昆虫天然免疫和发育,首先以鳞翅目害虫和埃及伊蚊这两种模式昆虫为研究对象,整合生理、生化、细胞、分子、遗传和组学研究方法和手段,在细胞、器官和个体水平上,对昆虫免疫、生殖发育等方面进行研究。发表SCI论文34篇,以主要作者发表于Immunity, PNAS, EMBO Report, PLoS Genetics, PLoS Pathogens等SCI期刊上。为Developmental and Comparative Immunology,Insect Biochemistry and Molecular Biology,BMC Genomics,PLoS One等20种杂志审稿人。

研究领域:
  目前有三个相辅相成的研究重点:非脊椎动物免疫系统的比较进化:卫生和农业昆虫的抗真菌、抗病毒免疫反应,激素调控的蚊虫生殖生物学。 
社会任职:
获奖及荣誉:
  2005年度国家优秀留学生奖学金和2005年度美国昆虫学会的Student Recognition Award in Insect Physiology, Biochemistry, Toxicology, and Molecular Biology。
承担科研项目情况:
代表论著:
  1. Saha, T.T. , Shin, S.W., Dou, W., Roy, S., Zhao, B., Hou, Y., Wang, X.L., Zou, Z., Girke, T., Raikhel, A.S.#. (2016) Hairy and Groucho mediate the action of juvenile hormone receptor Methoprene-tolerant in gene repression. Proc Natl Acad Sci USA 2016, 113(6):E735-43.
  2. Roy, S., Saha, T. T., Johnson, L., Zhao, B., Ha, J., White, K. P., Girke, T., Zou, Z.# and Raikhel, A. S.#, (2015). Regulation of gene expression patterns in mosquito reproduction. PLoS Genet, 11, e1005450.
  3. Hou, Y., Wang X.L., Saha, T.T., Roy, S., Zhao, B., Raikhel, A.S.#, Zou Z.# 2015. Temporal Coordination of Carbohydrate Metabolism during Mosquito Reproduction. PLoS Genetics 11(7): e1005309.
  4. Meng, Q., Yu, H.Y.,  Zhang, H., Zhu, W., Wang, M.L., Zhang, J.H., Zhou, G.L., Li, X., Qin, Q.L.#, Hu, S.N.#, Zou, Z.#. 2015. Transcriptomic insight into the immune defenses in the ghost moth, Hepialus xiaojinensis, during an Ophiocordyceps sinensis fungal infection. Insect Biochemistry and Molecular Biology, 64:1-15.
  5. Wang, Y.H., Hu, Y., Xing, L.S., Jiang, H., Hu, S.N., Raikhel, A.S. #, Zou, Z.# A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes. (2015) PLoS Pathog 11(6):e1004931.
  6. Xiong, G.H., Xing, L.S., Lin, Z., Saha, T.T., Wang, C., Jiang, H., Zou, Z. # High throughput profiling of the cotton bollworm Helicoverpa armigera immunotranscriptome during the fungal and bacterial infections. (2015) BMC Genomics 16(1):321.
  7. Shin, S.W., Zou, Z., Saha, T.T. and Raikhel, A.S. bHLH-PAS heterodimer of methoprene-tolerant and Cycle mediates circadian expression of juvenile hormone-induced mosquito genes (2012) Proc Natl Acad Sci USA 109(41): 16576-16581.
  8. Zou, Z.*, Souza-Neto, J.A.*, Xi, Z., Shin, S.W., Alvarez, K.S., Kokoza, K., Dimopoulos, G., Raikhel, A.S. Genome-wide transcriptome analysis of immunity related genes in the mosquito, Aedes aegypti. (2011) PLoS Pathogens, 7, e1002394.
  9. Shin, S.W.*, Zou, Z.*, Kokoza, V., Raikhel, A.S. Serine protease lection-2 (SPL2) is a negative modulator of hemolymph melanization and involved in modulation of melanization response to malaria infection in Aedes aegypti. (2011) EMBO Report,12, 938-43.
  10. Bartholomay, L.C., Waterhouse, R.M., Mayhew, G.F., Campbell, C.L., Michel, K., Zou, Z. et al. Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens. (2010) Science, 330, 88-90.
  11. Zou, Z.*, Shin, S.W.*, Alvarez, K.S., Kokoza, K., Raikhel, A.S. Distinct melanization pathways in the mosquito Aedes aegypti (2010) Immunity, 32, 41-53.
  12. Zou, Z., Zhao, P., Weng, H., Mita, K., Jiang, H. A comparative analysis of serpin genes in the silkworm genome. (2009) Genomics, 93, 367-75.
  13. Zou, Z.*, Shin, S.W.*, Alvarez, K.S., Bian, G., Kokoza, K., Raikhel, A.S. Mosquito RUNX4 in the immune regulation of PPO gene expression and its effect on avian malaria parasite infection. (2008) Proc. Natl. Acad. Sci. USA, 105, 18454-9.
  14. Zou, Z., Najar, F., Wang, Y., Roe, B., Jiang, H. Pyrosequence analysis of expressed sequence tags for Manduca sexta hemolymph proteins involved in immune responses. (2008) Insect Biochem. Mol. Biol., 38, 677-82.
  15. Tribolium Genome Sequencing Consortium, The first genome sequence of a beetle, Tribolium castaneum, a model for insect development and pest biology. (2007) Nature, 452, 949-55. Immunity group: Zou, Z., Evans, J., Lu, Z., Zhao, P., Williams, M., Sumathipala, N., Hetru, C., Hultmark, D., and Jiang, H.
  16. Zou, Z., Evans, J., Lu, Z., Zhao, P., Williams, M., Sumathipala, N., Hetru, C., Hultmark D., Jiang H. (2007) Comparative genomic analysis of the Tribolium immune system. Genome Biology, 8, R177.
  17. Waterhouse, R.M., Kriventseva, E.V., Meister, S., Xi, Z., Alvarez, K.S., Bartholomay, L.C., Barillas-Mury, C., Bian, G., Blandin, S., Christensen, B.M., Dong, Y., Jiang, H., Kanost, M.R., Koutsos, A.C., Levashina, E.A., Li, J., Ligoxygakis, P., Maccallum, R.M., Mayhew, G.F., Mendes, A., Michel, K., Osta, M.A., Paskewitz, S., Shin, S.W., Vlachou, D., Wang, L., Wei, W., Zheng, L., Zou, Z., Severson, D.W., Raikhel, A.S., Kafatos, F.C., Dimopoulos, G., Zdobnov, E.M., Christophides, G.K. (2007) Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science, 316, 1738-43. 
  18. Honeybee Genome Sequencing Consortium. Insights into social insects from the genome of the honeybee Apis mellifera. (2006) Nature, 443, 931-49. Coauthor in Haobo Jiang’s laboratory: Jiang, H. and Zou, Z.
  19. Zou, Z., Lopez, D., Kanost, M.R., Evans, J.D., Jiang, H. Comparative analysis of serine protease-related genes in the honey bee genome: possible involvements in embryonic development and innate immunity. (2006) Insect Mol. Biol., 15, 603-14.
  20. Wang, Y.*, Zou, Z.*, Jiang, H. An expansion of the dual clip-domain serine proteinase family in Manduca sexta: gene organization, expression, and evolution of prophenoloxidase-activating proteinase-2, hemolymph proteinase 12, and other related proteinases. (2006) Genomics, 87, 399-409.
  21. Pelte, N.*, Robertson, S.A.*, Zou, Z.*, Belorgey, D., Dafforn, R.T., Jiang, H., Lomas, D., Reichhart, J-M., Gubb, D. (2006) Immune challenge induces N-terminal cleavage of the Drosophila Necrotic serpin. Insect Biochem. Mol. Biol., 36, 37-46.
  22. Zou, Z., Jiang, H. Manduca sexta serpin-6: a natural regulator of immune serine proteinases PAP-3 and HP8: cDNA cloning, protein expression, inhibition kinetics and function elucidation. (2005) J. Biol. Chem., 280, 14341-8.
  23. Zou, Z., Jiang, H. (2005) Gene structure and transcriptional regulation of Manduca sexta prophenoloxidase-activating proteinase-3 (PAP-3), an immune protein containing two clip domains. Insect Mol. Biol.,14, 433-42.
  24. Zou, Z., Wang, Y and Jiang, H. (2005) Manduca sexta prophenoloxidase activating proteinase-1 (PAP-1) gene: organization, expression, and regulation by immune and hormonal signals. (2005) Insect Biochem. Mol. Biol., 35, 627-36.
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