研究队伍
院士专家
青年千人
百人计划
杰出青年
研究员
副研究员
人才招聘
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姓  名:
林海燕
学  科:
发育生物学
电话/传真:
+86-10-64807196 / 
电子邮件:
linhy@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 计划生育生殖生物学国家重点实验室 100101
更多信息:
生殖免疫研究组     
简历:

  林海燕,女,博士,副研究员。1997和2000年分别获北京师范大学学士和硕士学位。2005年获中国科学院动物研究所博士学位。2006年至2008年在加拿大不列颠哥伦比亚大学做博士后研究。主要从事胚胎着床和妊娠机制的研究工作,研究兴趣集中在母胎界面分子免疫调控机理,探索母胎免疫豁免的分子基础和复发流产的发病机制。先后主持国家优秀青年基金项目(2014)、国家自然科学基金青年科学基金和面上项目、中加国际合作与交流项目、中国科学院知识创新工程领域前沿项目等,国家重大科学研究计划研究骨干。迄今在Mol Aspects Med、J Clin Endocrinol Metab、J Biol Chem等期刊发表论文50余篇,其中第一作者或通讯作者论文20篇。

研究领域:
社会任职:
获奖及荣誉:
承担科研项目情况:
代表论著:
  1. Zheng R, Li Y, Sun H, Lu X, Sun BF, Wang R, Cui L, Zhu C, Lin HY*, Wang H. Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion. Reproduction, 2016, Oct 14. pii: REP-16-0343. [Epub ahead of print]
  2. Lu X, He Y, Zhu C, Wang H, Chen S*, Lin HY*. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta, 2016, 39, 45-54.
  3. Cui L, Wang H, Lu X, Wang R, Zheng R, Li Y, Yang X, Jia WT, Zhao Y, Wang Y, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. Effects of individually silenced N-glycosylation sites and non-synonymous single-nucleotide polymorphisms on the fusogenic function of human syncytin-2. Cell Adhesion & Migration, 2016, 10(1-2), 39-55.
  4. Lei JH, Yang XK, Peng S, Li Y, Underhill C, Zhu C, Lin HY*, Wang H*, Hammond GL*. Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex. J Clin Endocrinol Metab, 2015, 100, 1819-1827.
  5. Zhang Q, Yu S, Huang X, Tan Y, Zhu C, Wang Y, Wang H, Lin HY, Fu J*, Wang H*. New insights into the function of Cullin 3 in trophoblast invasion and migration. Reproduction, 2015, 150, 139-149.
  6. Li Y, Zheng R, Wang R, Lu X, Zhu C, Lin HY, Wang H, Yu X*, Fu J*. Involvement of nephrin in human placental trophoblast syncytialization. Reproduction, 2015, 149, 339-346.
  7. Zhou Z, Wang R, Yang X, Lu XY, Zhang Q, Wang YL, Wang H, Zhu C, Lin HY*, Wang H*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta, 2014, 35, 907-918.
  8. Wang R, Dang YL, Zheng R, Li Y, Li W, Lu X, Wang LJ, Zhu C, Lin HY*, Wang H*. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod, 2014, 90, 117.
  9. Chang W, Yang Q, Zhang H, Lin HY, Zhou Z, Lu X, Zhu C, Xue LQ*, Wang H*. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction, 2014, 148, 343-352.
  10. Li W, Liu D, Chang W, Lu XY, Wang YL, Wang H, Zhu C, Lin HY, Zhang Y, Zhou J*, Wang H*. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell Death Dis, 2014, 5, e1025.
  11. Zhou Z, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis, 2013, 4, e593.
  12. Zhang S#, Lin HY#, Kong S#, Wang S, Wang Hongmei, Wang Haibin*, Armant DR*. Physiological and molecular determinants of embryo implantation. Mol Aspects Med, 2013, 34, 939-980.
  13. Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis, 2013, 4, e502.
  14. Yang X, Wang Q, Gao Z, Zhou Z, Peng S, Chang WL, Lin HY, Zhang W*, Wang H*. Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. PLoS ONE, 2013, 8, e50479.
  15. Lin HY*, Underhill C, Lei JH, Helander-Claesson A, Lee HY, Gardill BR, Muller YA, Wang H*, Hammond GL*. High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects. J Clin Endocrinol Metab, 2012, 97, E678-E686.
  16. Zhao KQ, Lin HY*, Zhu C, Yang X, Wang H*. Maternal Smad3 deficiency compromises decidualization in mice. J Cell Biochem, 2012, 113, 3266-3275.
  17. Li Y, Wu L, Lei JH, Zhu C, Wang H, Yu XG*, Lin HY*. Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity. Sci China Life Sci, 2012, 55, 699-708.
  18. Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA*. Corticosteroid-binding globulin: structure-function implications from species differences. PLoS ONE, 2012, 7, e52759.
  19. Wu L, Zhou HH, Lin HY, Qi JG, Zhu C, Gao ZY*, Wang H*. Circulating microRNAs are elevated in plasma from severe pre-eclamptic pregnancies. Reproduction, 2012, 143, 389-397.
  20. Yang XK, Zhou Y, Peng S, Wu L, Lin HY, Wang SY*, Wang H*. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction, 2012, 144, 235-244.
  21. Lin HY*, Muller YA, Hammond GL*. Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol, 2010, 316, 3-12
  22. Fu J, Lv X, Lin HY, Wu L, Wang R, Zhou Z, Zhang B, Wang YL, Tsang BK, Zhu C, Wang H*. Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells. J Biol Chem, 2010, 285, 10870-10879.
  23. Lin HY, Underhill C, Gardill BR, Muller YA, Hammond GL*. Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J Biol Chem, 2009, 284, 884-896.
  24. Yang Q, Chen SP, Zhang XP, Wang H, Zhu C, Lin HY*. Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J Histochem Cytochem, 2009, 57, 605-612.
  25. Zhang B, Zhou Z, Lin HY, Lv X, Fu J, Lin P, Zhu C, Wang H*. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol, 2009, 132, 169-179.
  26. Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ*, Wang H*. The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion. Placenta, 2009, 30, 929-938.
  27. Zhang H, Lin HY, Yang Q, Wang HX, Chai KX, Chen LM, Zhu C*. Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy. J Histochem Cytochem, 2007, 55, 1237-1244.
  28. Yang Q, Lin HY, Wang HX, Zhang H, Zhang XP, Wang H, Zhu C*. Expression of smad ubiquitin regulatory factor 2 (Smurf2) in rhesus monkey endometrium and placenta during early pregnancy. J Histochem Cytochem, 2007, 55, 453-460.
  29. Zhang X, Zhu C, Lin HY, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S*, Wang H*. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod, 2007, 77, 358-364.
  30. Zhang H, Li Q, Lin HY, Yang Q, Wang H, Zhu C*. Role of PPARgamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro. Neuroendocrinol Lett, 2007, 28, 289-294.
  31. Lin HY, Yang Q, Wang H, Qi JG, Zhang H, Wang HX, Tsang BK, Zhu C*. Involvement of SMAD4, but not of SMAD2, in transforming growth factor-β1-induced trophoblast expression of matrix metalloproteinase-2. Front Biosci, 2006, 11, 637-646.
  32. Lin HY, Zhang H, Yang Q, Wang HX, Wang H, Chai KX, Chen LM*, Zhu C*. Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. J Histochem Cytochem, 2006, 54, 1139-1147.
  33. Lin HY, Qian D, Zhang X, Liu GY, Wang H, Zhu C*. Gene expression of transforming growth factor-β receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. Life Sci, 2006, 78, 2669-2675.
  34. Wang HX, Wang H, Lin HY, Yang Q, Zhang H, Tsang BK, Zhu C*. Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. J Cell Physiol, 2006, 206, 616-623.
  35. Liu GY, Zhang X, Lin HY, Wang H, Li QL, Ni J, Zhu C*. Effects of E-cadherin on mouse embryo implantation and expression of matrix metalloproteinase-2 and -9. Biochem Biophys Res Commun, 2006, 343, 832-838.
  36. Yang Q, Wang HX, Zhao YG, Lin HY, Zhang H, Wang H, Sang QA, Zhu C*. Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Life Sci, 2006, 78, 2804-2811.
  37. Zhang X, Lin HY, Liu GY, Wang H, Li QL, Zhu C*. Expressions and regulation of endothelial and inducible nitric oxide synthases in mouse uterus during the estrous cycle and early pregnancy. Front Biosci, 2005, 10, 3172-3182.
  38. Wang HX, Zhao YG, Wang H, Yang Q, Lin HY, Sang QA, Zhu C*. Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Mol Hum Reprod, 2005, 11, 429-435.
  39. Lin HY, Wang H, Li QL, Liu DL, Zhang X, Liu GY, Qian D, Zhu C*. Expression of Smad2 and Smad4, transforming growth factor-β signal transducers, in rat endometrium during the estrous cycle, pre-, and peri-implantation. Anim Reprod Sci, 2004, 80, 303-316.
  40. Qian D, Lin HY, Wang H, Zhang X, Liu DL, Li QL, Zhu C*. Normoxic induction of the hypoxic-inducible factor-1α by interleukin-1β involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells. Biol Reprod, 2004, 70, 1822-1827.
  41. Liu G, Lin HY, Zhang X, Li Q, Wang H, Qian D, Ni J, Zhu C*. Expression of Smad2 and Smad4 in mouse uterus during the estrous cycle and early pregnancy. Placenta, 2004, 25, 530-537.
  42. Qian D, Lin HY, Wang H, Zhang X, Li QL, Liu DL, Zhu C*. Involvement of ERK1/2 pathway in TGF-β1-induced VEGF secretion in normal human cytotrophoblast cells. Mol Reprod Dev, 2004, 68, 198-204.
  43. Zhang X, Wang H, Lin HY, Liu GY, Li QL, Zhu C*. Regulation of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) during mouse peri-implantation: role of nitric oxide. Placenta, 2004, 25, 243-252.
  44. Wang H, Zhang X, Qian D, Lin HY, Li QL, Liu DL, Liu GY, Yu XD, Zhu C*. Effect of ubiquitin-proteasome pathway on mouse blastocyst implantation and expression of matrix metalloproteinases-2 and -9. Biol Reprod, 2004, 70, 481-487.
  45. Wang HX, Wang H, Li QL, Lin HY, Qian D, Zhu C*. Expression of proteasome subunits LMP2 and LMP7 in the endometrium and placenta of rhesus monkey (Macaca mulatta)during early pregnancy. Biol Reprod, 2004, 71, 1317-1324.
  46. Lin HY, Wang H, Zhu C*. The Smad pathway in transforming growth factor-beta signaling. Sci China C Life Sci, 2003, 46, 449-463.
  47. Wang H, Li QL, Lin HY, Yu XD, Qian D, Dai JJ, Duan EK, Zhu C*. Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Mol Reprod Dev, 2003, 65, 123-131.
  48. Qian D, Wang H, Lin HY, Zhang X, Li QL, Liu DL, Liu GY, Zhu C*. Effect of UPP on the expression of VEGF and its receptors in mouse uterus during peri-implantation. Chin Sci Bull, 2003, 48, 338-342.
  49. Li QL, Wang H, Lin HY, Zhu C*. Expression of gelatinases and their tissue inhibitors in rat corpus luteum during pregnancy and postpartum. Mol Reprod Dev, 2002, 63, 273-281.
  50. Liu DL, Li QL, Lin HY, Liu WZ, Wang H, Zhang X, Zhu C*. Expression and localization of RAP250 mRNA in the rat ovary: Possible implications in follicular development and ovulation. Endocrine, 2002, 18, 173-178.
  51. Li QL, Wang H, Lin HY, Shao LJ, Ni J, Duan EK, Zhu C*. Expression of VEGF in the pregnant and postpartrum rat ovaries. Sci China C Life Sci, 2002, 45, 379-387.
  52. Zhang X, Wang H, Lin HY, Li QL, Liu DL, Qian D, Liu GY, Zhu C*. Regulation of blastocyst implantation by nitric oxide in mouse. Chin Sci Bul, 2002, 47, 1461-1465.
  53. Li QL, Wang H, Zhao YG, Lin HY, Sang QA, Zhu C*. Identification and specific expression of endometase/matrilysin-2 (MMP-26) in endometrium of rhesus monkey during early pregnancy. Mol Hum Reprod, 2002, 8, 934-940.
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