研究队伍
院士专家
青年千人
百人计划
杰出青年
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副研究员
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姓  名:
李孟华
学  科:
基因组生物学
电话/传真:
+86-10-64806336 / +86-10-64806336
电子邮件:
menghua.li@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号
中国科学院动物研究所 动物生态与保护生物学院重点实验室 100101
更多信息:
基因组学与动物遗传育种研究组     
简历:
  李孟华,研究员,博士生导师,基因组学与动物(主要是绵羊)遗传育种研究组组长。
  2003年毕业于华中农业大学畜牧兽医学院动物遗传育种与繁殖专业,获得博士学位;2003年 -2008年任芬兰农业食品科学研究院生物技术和食品研究部博士后; 2008年-2010年于赫尔辛基大学生物和环境科学系从事博士后研究; 2010年至2011年任芬兰农业食品科学研究院生物技术和食品研究部Principal Research Scientist (PI);2011年9月入选中国科学院 “百人计划”引进海外杰出人才。2010年6月被授予赫尔辛基大学Docent,并担任国际动物遗传学会羊专业委员会执行委员、Journal of Animal Breeding and Genetics等SCI杂志编委(Editorial Board member)和爱沙尼亚国家研究委员会科学基金评审人。
  共发表40多篇SCI论文,其中第一作者或通讯作者30多篇(分别在Molecular Biology and Evolution、Scientific Reports、Molecular Ecology、DNA Research、Heredity、BMC Genomics、G3:Genes, Genomics, Genetics、BMC Evolutionary Biology、Genetics Selection and Evolution、Animal GeneticsPLOS ONE等专业刊物)。
研究领域:
社会任职:
获奖及荣誉:
承担科研项目情况:
  • 中国科学院“百人计划”,2011-2013
  • 国家科技支撑计划,2012-2014
  • 国家自然科学基金面上项目,2013-2016
  • 国家自然科学基金新疆联合基金重点项目,2014-2017
  • 中国科学院对外合作重点项目,2015-2018
  • 国家自然科学基金NSFC-CGIAR国际合作重点项目,2017-2021
代表论著:

(#为共同第一作者,*为通讯作者)

2017年度:

  1. Xu Song-Song#, Ren Xue#, Yang Guang-Li#, Xie Xing-Long, Zhao Yong-Xin, Zhang Min, Shen Zhi-Qiang, Ren Yan-Ling, Gao Lei, Shen Min, Juha Kantanen and Meng-Hua Li* (2017) Genome-wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (Ovis aries) Animal Genetics (Accepted)
  2. Xu Song-Song, Meng-Hua Li* (2017) Recent advances in understanding genetic variants associated with economically important traits in sheep (Ovis aries) revealed by high-throughput screening technologies. Frontiers of Agricultural Sciences and Engineering (Invited Review; accepted)

2016年度:

  1. Ji Yang#, Wen-Rong Li#, Feng-Hua Lv#, San-Gang He#, Shi-Lin Tian#, Wei-Feng Peng, Ya-Wei Sun, Yong-Xin Zhao, Xiao-Long Tu, Min Zhang, Xing-Long Xie, Yu-Tao Wang, Jin-Quan Li, Yong-Gang Liu, Zhi-Qiang Shen, Feng Wang, Guang-Jian Liu, Hong-Feng Lu, Juha Kantanen, Jian-Lin Han, Meng-Hua Li* and Ming-Jun Liu*(2016)Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments. Molecular Biology and Evolution 33(10): 2576–2592.
    • 封面文章
    • 受到“International Livestock Research Institute (ILRI)”点评和报道
  2. Ren X#. Yang GL#, Peng WF, Zhao YX, Zhang M, Chen ZH, Wu FA, Kantanen J, Shen M, Li M.-H.* (2016) A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries) Scientific Reports 6:201111.
  3. Xiaoju Hu, Kisun Pokharel,Jaana Peippo, Nasser Ghanem, Ismael Zhaboyev, Juha Kantanen and Meng-Hua Li*. (2016)Identification and characterization of miRNAs in the ovaries of a highly prolific sheep breed. Animal Genetics 47:234-239.
2015年度:
  1. Lv F-H, Peng W-F, Yang J, Zhao Y-X, Li W-R, Liu M-J, Ma Y-H, Zhao Q-J, Yang G-L, Wang F, Li J-Q, Liu Y-G, Shen Z-Q, Zhao S-G, Hehua E, Gorkhali NA, Farhad Vahidi SM, Muladno M, Naqvi AN, Tabell J, Iso-Touru T, Bruford MW, Kantanen J, Han J-L*, Li M-H* (2015). Mitogenomic Meta-Analysis Identifies Two Phases of Migration in the History of Eastern Eurasian Sheep. Molecular Biology and Evolution 32: 2515-2533.
    • 封面文章
    • 受到“Financial Times”,“Modern Farmer”和“ILRI”等媒体报道和点评
    • 受到《中国科学》的评述
    • 中国科学院科研进展英文评述
  2. Jun Liu, Cuimin Wang, Dongli Fu, Xiaoju Hu, Xiangmo Xie, Pengfei Liu, Qiong Zhang and Meng-Hua Li* (2015) Phylogeography of Nanorana parkeri (Anura: Ranidae) on the Tibetan Plateau: effects of Plateau uplift and Quaternary climatic changes. Scientific Reports  5:9857
    • 中国科学院科研进展英文评述
  3. Weimin Zhao, Yulian Mu, Lei Ma, Chen Wang, Zhonglin Tang, Shulin Yang, Rong Zhou, Xiaoju Hu, Meng-Hua Li* and Kui Li* (2015) Systematic identification and characterization of long intergenic non-coding RNAs in fetal porcine skeletal muscle development. Scientific Reports 5:8957.
  4. Kisun Pokharel, Jaana Peippo, Göran Andersson, Meng-Hua Li*, Juha Kantanen (2015) Transcriptome profiling of Finnsheep ovaries during out-of-season breeding period. Agricultural and Food Science 24: 1-9.
  5. Kantanen J, Løvendahl P, Strandberg E, Eythorsdottir E, Li M.-H., Kettunen-Præbel A, Berg P, Meuwissen T. (2015) Utilization of farm animal genetic resources in a changing agro-ecological environment in the Nordic countries. Frontiers in Genetics 6:52.

2014年度:

  1. Feng-Hua Lv, Saif Agha, Juha Kantanen, LiciaColli, Sylvie Stucki, James W. Kijas, Stéphane Joost, Meng-Hua Li*, Paolo Ajmone Marsan (2014) Adaptations to Climate-Mediated Selective Pressures in Sheep. Molecular Biology and Evolution 31: 3324-3343.
    • 封面文章
    • 受到Science daily等媒体报道和点评
  2. Ji Yang, Takahito Shikano, Meng-Hua Li*, Juha Merilä (2014) Genome-wide linkage disequilibrium in nine-spined stickleback. G3 – Genes Genomes Genetics4:1119-1129
  3. Yang J, Li M.-H.* (2014) A multi-omics integrated study deciphers biology of the rumen and lipid metabolism. Science China Life Science 57: 951-953
    • 特邀评述
  4. Liu J., T. Shikano, T. Leinonen, J. M. Cano, M.-H. Li*, J. Merilä (2014) Identification of major and minor QTL for ecologically important morphological traits in three-spined sticklebacks (Gasterosteus aculeatus). G3-Genes, Genomes, Genetics 4: 594-604
  5. Shan L., Wu Q., Li Y., Shang H., Guo K., Wu J., Wei H., Zhao J., Yu J., Li M.-H.*(2014) Transcriptome profiling identifies differentially expressed genes in postnatal developing pituitary gland of miniature pig. DNA Research 21:207-216
  6. Li M.-H.*, T. Tiirikka, J. Kantanen (2014) A genome-wide scan study identifies a single nucleotide substitution in ASIP associated with white versus non-white coat-colour variation in sheep (Ovisaries). Heredity 112: 122–131.
  7. Zhang Min, Wei-Feng Peng, Guang-Li Yang, Feng-Hua Lv, Ming-Jun Liu, Wen-Rong Li, Yong-Gang Liu, Jin-Quan Li, Feng Wang, Zhi-Qiang Shen, Sheng-Guo Zhao, EEr Hehua, Nurbiy Marzanov, Maziek Murawski, Juha Kantanen and Meng-Hua Li (2014) Y chromosome haplotype diversity of domestic sheep (Ovis aries) in northern Eurasia. Animal Genetics 45:903-907.

2011-2013年度:

  1. Wang C., Hu X., Xie X., Liu P., Merilä J., Zhang Q. *, Li M.-H.* (2013) Isolation and characterization of 113 polymorphic microsatellite loci for the Tibetan frog (Nanoranaparkeri) using next generation sequencing. Conservation Genetics Resources 5: 915-924.
  2. Li M.-H., A.Osva, J. Kantanen (2012) Integrating multidisciplinary data for the conservation of livestock biodiversity: a case study of the Yakutian cattle in Siberia, the far east of Russia. Animal Genetics Resources 50:97-104.
  3. Li M. H.* and J. Merilä (2011) Population differences in levels of linkage disequilibrium in the wild. Molecular Ecology 20: 2916-2928.
  4. Li M.-H., I. Strandén, T. Tiirikka, M.-L. Sevón-Aimonen, J. Kantanen (2011) A comparison of approaches to estimate the inbreeding coefficient and pairwise relatedness using genomic and pedigree data in a sheep population. PLoS ONE 6: e26256.
  5. Cano J.M., M.-H. Li, Laurila A, Vilkki J, Merilä J. (2011) First-generation linkage map for the common frog Ranatemporaria reveals sex linkage group.Heredity107: 530-536.
  6. Li M.-H.*, J. Kantanen, A. Michelson, U. Saarma (2011) Genetic components of grey cattle in Estonia as revealed by microsatellite analysis using two Bayesian clustering methods. BMC Research Notes 4: 37.
  7. Zerabruk M.#, Li M.-H. #, J. Kantanen, I. Olsaker, E. M. Ibeagha-Awemu, G. Erhardt, D. G. Bradley and O Vangen (2011) Genetic diversity and admixture of indigenous cattle breeds of North Ethiopia: implications to historical introgressions in the gateway region of cattle to Africa. Animal Genetics 43:257-266.
  8. Nair A., S. Kumar, S. George, S. Gopalan, M.-H. Li, E. Leder and J. Merilä (2011) Sixty two new microsatellite markers for an endemic frog Indiranabeddomii from the Western Ghats biodiversity hotspot. Conservation Genetics Resources 3: 167-171.

2001-2010年度:

  1. Tapio, I., Tapio, M., M.-H. Li, Popov, R., Ivanova, Z., Kantanen, J (2010) Estimation of relatedness among non-pedigreed Yakutiancryo-bank bulls using molecular data: implications for conservation and breed management. Genetics Selection Evolution 42: 9.
  2. Li M. H.* and J. Merilä (2010) Genetic evidence for male-biased dispersal in the Siberian jay (Perisoreus infaustus) based on autosomal and Z chromosomal markers. Molecular Ecology 19: 5281-5295.
  3. Li, M.H., Kantanen, J (2010) Genetic structure of Eurasian cattle (Bos taurus) based on microsatellites: clarification for their breed classification. Animal Genetics 41: 150-158.
  4. Li, M.H., Iso-Touru, T., Lauren, H., Kantanen, J (2010) A microsatellite-based analysis for the detection of selection on BTA1 and BTA20 in northern Eurasian cattle (Bos taurus) populations. Genetics Selection Evolution 42: 14.
  5. Li M. H.* and J. Merilä (2010) Avian Z-specific microsatellites map to pseudoautosomal or autosomal chromosomes in the Siberian jay (Perisoreus infaustus): insights into avian genome evolution from cross-species amplification tests. Journal of Genetics 89: 223-228.
  6. Li M.-H.* and J. Merilä(2010) Sex-specific population structure, natural selection, and linkage disequilibrium in a wild bird population as revealed by genome-wide microsatellite analyses. BMC Evolutionary Biology 10: 66.
    • 受到 Science (328:19)“编辑的选择”栏目评述
  7. Li M.-H.*, and J. Merilä (2010) Extensive linkage disequilibrium in a wild bird population. Heredity 104: 600-610.
  8. Iso-Touru, T., J. Kantanen, M. H. Li, Z. Gizejewski and J.Vilkki (2009) Divergent evolution in cattle and pigs in the cytoplasmic domains of GHR and PRLR. BMC Evolutionary Biology 9:172.
  9. Li M.-H.* K. Välimäki, M. Piha, T.Pakkala and J. Merilä (2009) Extrapair paternity and maternity in the three-toed woodpecker, Picoides tridactylus: insights from microsatellite-based parentage analysis. PLoS ONE 4: 1-6.
  10. Li M.-H., I. Strandén, and J. Kantanen (2009) Genetic diversity and pedigree analysis of the Finnsheep breed. Journal of Animal Science 87:1598-1605.
  11. Jarri S., M.-H. Li*, and J. Merilä (2009) A first-generation microsatellite-based genetic linkage map of the Siberian jay (Perisoreusinfaustus): insights into avian genome evolution. BMC Genomics 10: 1.
  12. Agha S. H., F. Pilla, S. Galal, I. Shaat, M. D’Andrea, S. Reale, A. Z. A. Abdelsalam, and M.-H. Li (2008) Genetic diversity in Egyptian and Italian goat breeds measured with microsatellite polymorphism. Journal of Animal Breeding and Genetics 125: 194-200.
  13. Li M.-H., I. Tapio, J. Vilkki, Z. Ivanova, T. Kiselyova, N. Marzanov, M. Cinkulov, S. Stojanovic, I. Ammosov, R. Popov, and J. Kantanen (2007) Genetic structure of cattle populations (Bostaurus) in northern Eurasia and the neighboring Near Eastern regions: implications for breeding strategies and conservation. Molecular Ecology 16:3839-3853.
    • 封面文章
  14. Li M.-H., M. Zerabruk, O. Vangen, I. Olsaker, and J. Kantanen (2007) Reduced genetic structure of north Ethiopian cattle revealed by Y-chromosome analysis. Heredity 98: 214-221.
  15. Li M.-H., T. Adamowicz, M. Switonski, I. Ammosov, Z. Ivanova, T. Kiselyova, R. Popov, and J. Kantanen (2006) Analysis of population differentiation in North Eurasian cattle (Bostaurus) using single nucleotide polymorphisms in three genes associated with production traits. Animal Genetics 37: 390-392.
  16. Bennewitz J., J. Kantanen, I. Tapio, M.-H. Li, E. Kalm, J. Vilkki, I. Ammosov, Z. Ivanova, T. Kiselyova, R. Popov, and T. H. Meuwissen (2006) Estimation of breed contributions to present and future genetic diversity of 44 North Eurasian cattle breeds using core set diversity measures. Genetics Selection Evolution 38: 201-220.
  17. Li M.-H., K. Li, J. Kantanen, Z. Feng, B. Fan, and S. H. Zhao (2006) Allelic variations in exon 2 of caprine MHC class II DRB3 gene in Chinese indigenous goats. Small Ruminant Research 66: 236-243.
  18. Li M.-H., E. Nogovitsina, Z. Ivanova, G. Erhardt, J. Vilkki , R. Popov, I. Ammosov, T. Kiselyova, and J. Kantanen (2005) Genetic contributions of indigenous Yakutian cattle to two hybrid populations as revealed by microsatellite variation. Asian-Australasian Journal of Animal Sciences 18: 613-1619.
  19. Li, M.-H., K. Sternbauer, P. T. Haahr, and J. Kantanen (2005) Genetic components in contemporary Faroe Islands Cattle as revealed as microsatellite analysis. Journal of Animal Breeding and Genetics 122: 309-317.
  20. Li S. J., S. H, Yang, S. H. Zhao, B. Fan, M. Yu, H. S. Wang, M.-H. Li, B. Liu, T. A. Xiong, and K. Li (2004) Genetic diversity analyses of 10 indigenous Chinese pig populations based on 20 microsatellites. Journal of Animal Science 82:368-374.
  21. Li M.-H., S, H. Zhao, and K. Li (2004) Diversity of Chinese indigenous goat breeds: a conservation perspective – a review. Asian-Australasian Journal of Animal Sciences 17: 726-732.
  22. Mo D. L., B. Liu, Z. G. Wang, S. H. Zhao, M. Yu, B. Fan, M.-H. Li, T. A. Xiong, M. Yu, and K. Li (2003) Genetic variation and genetic relationship of seventeen Chinese indigenous pig breeds using ten serum protein loci. Asian-Australasian Journal of Animal Sciences 16: 939-945.
  23. Yang S. L, Z. G Wang, B. Liu, G. X. Zhang, S. H. Zhao, M. Yu, B. Fan, M.-H. Li, and K. Li (2003) Genetic variation and relationships of eighteen Chinese indigenous pig breeds. Genetics Selection Evolution 35: 657-671.
  24. Fan B., Z. G. Wang, Y. J. Li, X. L. Zhao, B. Liu, S. H. Zhao, M Yu, M.-H. Li, S. L. Chen, T.A. Xiong, and K. Li (2002) Genetic variation analysis within and among Chinese indigenous swine populations using microsatellite markers. Animal Genetics 33: 422-427.
  25. Li M.-H., S. H. Zhao, C. Bian, H. S. Wang, H. Wei, B.Liu, M. Yu, B. Fan, S. L. Chen, M. J. Zhu, T. A. Xiong, and K. Li (2002) Genetic relationships among twelve indigenous Chinese goat populations based on microsatellite analysis. Genetics Selection Evolution 34: 729-744.
  26. Chen S. L., M.-H. Li, Y. J. Li, S.H. Zhao, C. Z. Yu, M. Yu, B. Fan, T. A. Xiong, and K. Li (2001) RAPD variation and genetic distances among Tibetan, Inner Mongolia and Liaoning Cashmere goats. Asian-Australasian Journal of Animal Sciences 14: 1520-1522.
  27. Sakha Ynaga. Cattle of the Yakuts (Granberg L., J. Kantanen& K. Soinieds). Finnish Academy of Science and Letters, Helsinki, Finland. 218 pp. (ISBN978-951-41-1032-0, Li M.-H.是该书的主要的编著者之一).
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