研究队伍
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青年千人
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姓  名:
王震波
学  科:
发育生物学
电话/传真:
+86-10-64807126 / 
电子邮件:
wangzb@ioz.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院五号
中国科学院动物研究所干细胞与生殖生物学国家重点实验室 100101
更多信息:
受精生物学研究组     
简历:

  王震波,男,1981年2月出生于山东省淄博市,理学博士,研究员,干细胞与生殖生物学国家重点实验室受精生物学研究组成员。主要从事哺乳动物卵泡发育及卵母细胞成熟机理研究,相关研究成果已发表SCI收录论文50余篇。

教育背景及工作经历:

  • 2017年1月 – 至今, 中国科学院动物研究所,研究员。
  • 2013年1月 - 2016年12月,中国科学院动物研究所,副研究员。
  • 2012年7月 - 2012年12月,中国科学院动物研究所,助理研究员。
  • 2010年7月 - 2012年6月,中国科学院动物研究所,博士后。
  • 2004年9月 - 2010年7月,中国科学院动物研究所计划生育生殖生物学国家重点实验室获发育生物学博士学位。
  • 2006年6月 - 2008年6月, 加拿大渥太华大学健康研究所,访问研究生。
  • 2000年9月 - 2004年7月, 中国农业大学生物学院,获理学学士学位。 
研究领域:
  哺乳动物卵泡发育及卵母细胞成熟机理。
社会任职:
获奖及荣誉:
  • 中国科学院青年创新促进会会员(2017)
  • 全国妇幼健康科学技术奖自然科学一等奖(2015)
  • 中国动物学会生殖生物学分会青年科技奖(2015)
  • 国家人口与计划生育委员会优秀科技成果一等奖(2011)
承担科研项目情况:
  • 国家重点研发计划项目(科研骨干),2016-2020
  • 国家自然科学基金面上项目(31671559),2017-2020
  • 国家自然科学基金面上项目(31371451),2014-2017
  • 国家自然科学青年基金项目(31201078),2013-2015
代表论著:
  1. Hu MW, Meng TG, Jiang ZZ, Dong MZ, Schatten H, Xu X, Wang ZB#, Sun QY# (2016). Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic Integrity. PLoS Genet. Dec 8;12(12):e1006513. (#corresponding author)
  2. Wang ZB, Ma XS, Hu MW, Jiang ZZ, Meng TG, Dong MZ, Fan LH, Ouyang YC, Snapper SB, Schatten H, Sun QY(2016).Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion. Mol Hum Reprod. Sep, 22(9):613-21.
  3. Ma XS, Lin F, Wang ZW, Hu MW, Huang L, Meng TG, Jiang ZZ, Schatten H, Wang ZB#, Sun QY# (2016). Geminin Deletion in Mouse Oocytes Results in Impaired Embryo Development and Reduced Fertility. Mol Biol Cell. Mar 1; 27(5):768-75.(#corresponding author)
  4. Jiang ZZ, Hu MW, Ma XS, Schatten H, Fan HY, Wang ZB#, Sun QY# (2015). LKB1 acts as a critical gatekeeper of ovarian primordial follicle pool. Oncotarget. Feb 2;7(5):5738-53. (#corresponding author)
  5. Hu MW*, Wang ZB*, Teng Y*, Jiang ZZ, Ma XS, Hou N, Cheng X, Schatten H, Xu X, Yang X, Sun QY(2015). Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility. J Cell Sci Oct 15;128(20):3769-80.(封面文章)(*co-first author)
  6. Liang QX, Zhang QH, Qi ST, Wang ZW, Hu MW, Ma XS, Zhu MS, Schatten H, Wang ZB#, Sun QY#(2015). Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice. Biol Reprod 92(4):97. (#corresponding author)
  7. Hu MW*, Wang ZB*, Jiang ZZ, Qi ST, Huang L, Liang QX, Schatten H, Sun QY(2014). Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility. Biol Reprod 91(1):19. (*co-first author)
  8. Jiang ZZ*, Hu MW*, Wang ZB*, Huang L, Lin F, Qi ST, Ouyang YC, Fan HY, Schatten H, Mak TW, Sun QY(2014). Survivin is essential for fertile egg production and female fertility in mice. Cell Death Dis 5:e1154. (*co-first author)
  9. Wang ZB, Jiang ZZ, Zhang QH, Hu MW, Huang L, Ou XH, Guo L, Ouyang YC, Hou Y, Brakebusch C, Schatten H, Sun QY(2013).Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation, but disrupts polarity establishment and cytokinesis in mouse oocyte. Mol Biol Cell 24(24):3832-41
  10. Qiao J*, Wang ZB*, Feng HL*, Miao YL, Wang Q, Yu Y, Wei YC, Yan J, Wang WH, Shen W, Sun SC, Schatten H, Sun QY(2014). The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects. Mol Aspects Med 38:54-85. (*co-first author)
  11. Huang L*, Wang ZB*, Jiang ZZ, Hu MW, Lin F, Zhang QH, Luo YB, Hou Y, Zhao Y, Fan HY, Schatten H, Sun QY(2013). Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea. PLoS One (1):e54052. (*co-first author)
  12. Wang ZB, Schatten H, Sun QY (2011).Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging? Physiology (Bethesda) 26(5):314-25.(封面文章)
  13. Wang ZB, Ou XH, Tong JS, Li S, Wei L, Ouyang YC, Hou Y, Sun QY (2010). The SUMO pathway functions in mouse oocyte maturation. Cell Cycle 9(13):2638-44.
  14. Wang L*,Wang ZB*, Zhang X, Harris GF, Baltz JM, Sun QY, Liu XJ (2008). Brefeldin A disrupts asymmetric spindle positioning in mouse oocytes. Dev Biol 313(1):155-66. (*co-first author)
  15. Zhang T, Zhou Y, Li L, Wang ZB, Shen W, Schatten H, Sun QY(2016).CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes. Development. Dec 19. pii: dev.141135
  16. Huang L, Wang ZB, Qi ST, Ma XS, Liang QX, Lei G, Meng TG, Liang LF, Xian YX, Hou Y, Sun XF, Zhao Y, Wang WH, Sun QY (2016). Rad9a is required for spermatogonia differentiation in mice. Oncotarget. Nov 16. doi: 10.18632/oncotarget.13405.
  17. Wang HH, Cui Q, Zhang T, Guo L, Dong MZ, Hou Y, Wang ZB, Shen W, Ma JY, Sun QY(2017). Removal of mouse ovary fat pad affects sex hormones, folliculogenesis and fertility. J Endocrinol. Feb;232(2):155-164.
  18. Qi ST, Ma JY, Wang ZB, Guo L, Hou Y, Sun QY (2016). N6-Methyladenosine sequencing highlights the involvement of mRNA methylation in oocyte meiotic maturation and embryo development by regulating translation in Xenopus laevis. J Biol Chem. Oct 28; 291(44):23020-23026.
  19. Liu SZ, Wei ZF, Meng XQ, Han XY, Cheng D, Zhong T, Zhang TL, Wang ZB (2016). Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation. Environ Toxicol. Nov; 31(11):1652-1662.
  20. Guo L, Wang ZB, Wang HH, Zhang T, Qi ST, Ouyang YC, Hou Y, Sun QY(2016). Nek11 regulates asymmetric cell division during mouse oocyte meiotic maturation. Biochem Biophys Res Commun. Jun 10;474(4):667-72
  21. Xu ZY, Ma XS, Qi ST, Wang ZB, Guo L, Schatten H, Sun QY, Sun YP (2015). Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte. Sci Rep. 2015 Nov 19;5:16978.
  22. Liu SZ, Wei ZF, Meng XQ, Han XY, Cheng D, Zhong T, Zhang TL, Wang ZB (2015). Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation. Environ Toxicol  Jul 15. doi: 10.1002/tox.22169. [Epub ahead of print]
  23. Wang F, Zhang L, Duan X, Zhang GL, Wang ZB, Wang Q, Xiong B, Sun SC (2015). RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis. Cell Cycle 14(17):2835-43.
  24. Zhang T, Zhou Y, Qi ST, Wang ZB, Qian WP, Ouyang YC, Shen W, Schatten H, Sun QY(2015). Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation.Cell Cycle 14(16):2701-10.
  25. Qi ST, Wang ZB, Huang L, Liang LF, Xian YX, Ouyang YC, Hou Y, Sun QY, Wang WH(2015).Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.Cell Cycle 14(11):1675-85.
  26. Zhu L, Han CS, Cao ZL, Wang ZB, Han RG, Wang B, Sun QY(2015). Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients. Gynecol Obstet Invest 80(3):179-86
  27. Chen L, Ge ZJ, Wang ZB, Sun T, Ouyang YC, Sun QY, Sun YP (2014). TGN38 is required for the metaphase I/anaphase I transition and asymmetric cell division during mouse oocyte meiotic maturation. Cell Cycle 13(17):2723-32.
  28. Lin F, Ma XS, Wang ZB, Wang ZW, Luo YB, Huang L, Jiang ZZ, Hu MW, Schatten H, Sun QY (2014). Different fates of oocytes with DNA double-strand breaks in vitro and in vivo. Cell Cycle 13(17):2674-80.
  29. Ma JY, Zhao K, OuYang YC, Wang ZB, Luo YB, Hou Y, Schatten H, Shen W, Sun QY(2014). Exogenous thymine DNA glycosylase regulates epigenetic modifications and meiotic cell cycle progression of mouse oocytes. Mol Hum Reprod 21(2):186-94.
  30. Yu XJ, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang ZB, Zheng P, Zhu MS, Wang H, Sun QY, Dean J, Li L (2014). The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nat Commun 5:4887.
  31. Wang F, Zhang L, Zhang GL, Wang ZB, Cui XS, Kim NH, Sun SC(2014).WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes. Sci Rep 4:5596.
  32. Wang QC, Liu J, Wang ZB, Zhang Y, Duan X, Cui XS, Kim NH, Sun SC (2014).Dynamin 2 regulates actin-mediated spindle migration in mouse oocytes. Biol Cell 106(6): 193- 202.
  33. Zhang T, Zhang GL, Ma JY, Qi ST, Wang ZB, Wang ZW, Luo YB, Jiang ZZ, Schatten H, Sun QY(2014). Effects of DNA damage and short-term spindle disruption on oocyte meiotic maturation. Histochem Cell Biol 142(2):185-94.
  34. Duan X, Liu J, Dai XX, Liu HL, Cui XS, Kim NH, Wang ZB, Wang Q, Sun SC (2014). Rho-GTPase effector ROCK phosphorylates cofilin in actin-meditated cytokinesis during mouse oocyte meiosis. Biol Reprod 90(2):37.
  35. Liu J, Wang QC, Cui XS, Wang ZB, Kim NH, Sun SC(2013).MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation. Reprod Biol Endocrinol 11:117.
  36. Wang ZW, Ma XS, Ma JY, Luo YB, Lin F, Wang ZB, Fan HY, Schatten H, Sun QY(2013). Laser microbeam-induced DNA damage inhibits cell division in fertilized eggs and early embryos. Cell Cycle 12(20):3336-44.
  37. Luo SM, Ge ZJ, Wang ZW, Jiang ZZ, Wang ZB, Ouyang YC, Hou Y, Schatten H, Sun QY (2013). Unique insights into maternal mitochondrial inheritance in mice. Proc Natl Acad Sci U S A 110(32):13038-43.
  38. Ma JY, Ou Yang YC, Wang ZW, Wang ZB, Jiang ZZ, Luo SM, Hou Y, Liu ZH, Schatten H, Sun QY(2013). The effects of DNA double-strand breaks on mouse oocyte meiotic maturation.Cell Cycle 12(8):1233-41.
  39. Ma JY, Ou-Yang YC, Luo YB, Wang ZB, Hou Y, Han ZM, Liu Z, Schatten H, Sun QY(2013).Cyclin O regulates germinal vesicle breakdown in mouse oocytes. Biol Reprod 88(5):110.
  40. Qi ST, Wang ZB, Ouyang YC, Zhang QH, Hu MW, Huang X, Ge Z, Guo L, Wang YP, Hou Y, Schatten H, Sun QY(2013). Overexpression of SETβ, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes. J Cell Sci 126(Pt 7):1595-603.
  41. Li S, Ou XH, Wei L, Wang ZB, Zhang QH, Ouyang YC, Hou Y, Schatten H, Sun QY(2012). Septin 7 is required for orderly meiosis in mouse oocytes. Cell Cycle 11(17):3211-8.
  42. Ou XH, Li S, Wang ZB, Li M, Quan S, Xing F, Guo L, Chao SB, Chen Z, Liang XW, Hou Y, Schatten H, Sun QY(2012). Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes. Hum Reprod 27(7):2130-45.
  43. Chen L, Chao SB, Wang ZB, Qi ST, Zhu XL, Yang SW, Yang CR, Zhang QH, Ouyang YC, Hou Y, Schatten H, Sun QY(2012). Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes. Cell Cycle 11(10):1948-55.
  44. Hu MW, Wang ZB, Schatten H, Sun QY(2012). New understandings on folliculogenesis/ oogenesis regulation in mouse as revealed by conditional knockout. J Genet Genomics 39(2):61-8.
  45. Zhang QH, Qi ST, Wang ZB, Yang CR, Wei YW, Chen L, Ouyang YC, Hou Y, Schatten H, Sun QY (2012).Localization and function of the Ska complex during mouse oocyte meiotic maturation. Cell Cycle 11(5): 909-916.
  46. Chao SB, Guo L, Ou XH, Luo SM, Wang ZB, Schatten H, Gao GL, Sun QY (2012).Heated spermatozoa: effects on embryonic development and epigenetics. Hum Reprod 27(4):1016-1024.
  47. Zhu J, Qi ST, Wang YP, Wang ZB, Ouyang YC, Hou Y, Schatten H, Sun QY(2011).Septin1 is required for spindle assembly and chromosome congression in mouse oocytes. Dev Dyn 240(10):2281-9.
  48. Wei Y, Multi S, Yang CR, Ma J, Zhang QH, Wang ZB, Li M, Wei L, Ge ZJ, Zhang CH, Ouyang YC, Hou Y, Schatten H, Sun QY(2011).Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development. PLoS One 6(6):e21557
  49. Huang X, Wang HL, Qi ST, Wang ZB, Tong JS, Zhang QH, Ouyang YC, Hou Y, Schatten H, Qi ZQ, Sun QY (2011).DYNLT3 Is Required for Chromosome Alignment During Mouse Oocyte Meiotic Maturation. Reprod Sci 18(10):983-9.
  50. Zhang CH, Wang ZB, Quan S, Huang X, Tong JS, Ma JY, Guo L, Wei YC, Ouyang YC, Hou Y, Xing FQ, Sun QY (2011).GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte. Cell Cycle 10(11):1861-70.
  51. Leblanc J, Zhang X, McKee D, Wang ZB, Li R, Ma C, Sun QY, Liu XJ (2011).The Small GTPase Cdc42 Promotes Membrane Protrusion during Polar Body Emission via ARP2-Nucleated Actin Polymerization. Mol Hum Reprod 17(5):305-316.
  52. Sun SC, Wang ZB, Xu YN, Lee SE, Cui XS, Kim NH (2011). Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. PLoS One 6(4):e18392.
  53. Huang X, Tong JS, Wang ZB, Yang CR, Qi ST, Guo L, Ouyang YC, Quan S, Sun QY, Qi ZQ, Huang RX, Wang HL (2011).JNK2 Participates in Spindle Assembly during Mouse Oocyte Meiotic Maturation. Microsc Microanal 17(2):197-205.
  54. Tong JS, Zhang QH, Wang ZB, Li S, Yang CR, Fu XQ, Hou Y, Wang ZY, Sheng J, Sun QY (2010).ER-α36, a novel variant of ER-α, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCδ/ERK pathway. PLoS One 5(11):e15408.
  55. Ou XH, Li S, Xu BZ, Wang ZB, Quan S, Li M, Zhang QH, Ouyang YC, Schatten H, Xing FQ, Sun QY (2010).P38α MAPK is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation.Cell Cycle 9(20):4130-43.
  56. Li S, Ou XH, Wang ZB, Xiong B, Tong JS, Wei L, Li M, Yuan J, Ouyang YC, Hou Y, Schatten H, Sun QY (2010).ERK3 Is Required for Metaphase-Anaphase Transition in Mouse Oocyte Meiosis. PLoS ONE 5(9): e13074.
  57. Li M, Li S, Yuan J, Wang ZB, Sun SC, Schatten H, Sun QY (2009).Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. PLoS One 4(11):e7701.
  58. Lin SL, Yan LY, Liang XW, Wang ZB, Wang ZY, Qiao J, Schatten H, Sun QY (2009). A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells. Reprod Biol Endocrinol 7:102.
  59. Ola SL, Ai JS, Liu JH, Wang Q, Wang ZB, Chen DY, Sun QY (2008).Effects of gonadotrophins, growth hormone and activin A on enzymatically isolated follicle growth, oocyte chromatin organization and steroid secretion. Mol Reprod Dev 75(1):89-96.
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