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    Name:
    		 WU Yijun
    Subject:
    		 Cell Biology
    Tel/Fax:
    		 +86-10-64807251  /  +86-10-64807099
    E-mail:
    		 wuyj@ioz.ac.cn
    Address:
    		 The State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
    More:
    		 Group of Molecular Toxicology      

    Resume：

    Dr. Yi-Jun Wu received his doctoral degree from the Graduate School of Chinese Academy of Sciences (Zoology) in 1995 and then he joined Institute of Zoology (IOZ), Chinese Academy of Sciences (CAS). He received his postdoctoral training in molecular biology in the Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, USA (1999-2001). In 2001, he rose to Professor in IOZ, CAS.
    Research Interest：

    Research in Dr. Wu’ lab (LMT) emphasizes the molecular mechanism of pesticides toxicity, which is important for understanding environmental chemical characteristics of pesticides, improving their selectivity, reducing the use of pesticides, and minimizing the hazards of exposure to humans, domestic animals, and other non-target species. Recent research involves four closely related topics, as described below.

    1. Mechanism of pesticide neurotoxicity on humans and other susceptible animals with an emphasis on organophosphate-induced delayed neurotoxicity (OPIDN)
    2. Study of multi-target joint toxicity of pesticides to help assess the environmental risk of pesticides
    3. Environmental safety of pesticides: Degradation of pesticides residues by genetically engineered bacteria
    4. Biochemical and molecular mechanism of resistance of insects to the insecticides
    Public Services：

    Awards and Honors：

    Research Grants：

    Selected Publication：
    1. Xu HY, Sun YJ, Sun YY, Wu YJ, Xu MY, Chen LP, Zhu L. Lapatinib alleviates TOCP-induced axonal damage in the spinal cord of mouse. Neuropharmacology. 2021, 189: 108535.
    2. Li J, Qin Q, Li YX, Leng XF, Wu YJ. Tri-ortho-cresyl phosphate exposure leads to low egg production and poor eggshell quality via disrupting follicular development and shell gland function in laying hens. Ecotoxicol Environ Saf. 2021, 225: 112771.
    3. Chen LP, Xing XJ, Kang KL, Yang WY, Luo L, Wu YJ. Why are Drosophila larvae more sensitive to avermectin than adults? Comp Biochem Physiol Part C. 2022, 251: 109197.
    4. Wang P, Wu YJ, Sun ML. Decrease of an intracellular organic osmolyte contributes to the cytotoxicity of organophosphate in neuroblastoma cells in vitro. Toxicology. 2021, 453:152725.
    5. Li Q, Li J, Kang KL, Wu YJ. A safety type of genetically engineered bacterium that degrades chemical pesticides. AMB Express. 2020, 10(1): e33.
    6. Xu MY, Sun YJ, Wang P, Yang L, Wu YJ. Metabolomic biomarkers in urine of rats following long-term low-dose exposure of cadmium and/or chlorpyrifos. Ecotoxicol Environ Saf. 2020, 195: 110467.
    7. Xu MY, Wang P, Sun YJ, Yang L, Wu YJ. Identification of metabolite biomarkers in serum of rats exposed to chlorpyrifos and cadmium. Sci Rep. 2020, 10(1): e4999.
    8. Hou RY, Wang L, Wu YJ. Predicting ATP-binding cassette transporters using the random forest method. Front Genet. 2020, 11: 156.
    9. Hou RY, Wu J, Xu L, Zou Q, Wu YJ. Computational prediction of protein arginine methylation based on composition-transition-distribution (CTD) features. ACS Omega. 2020, 5(42):27470-27479.
    10. Wang P, Yang M, Jiang L, Wu YJ. A fungicide miconazole ameliorates tri-o-cresyl phosphate-induced demyelination through inhibition of ErbB/Akt pathway. Neuropharmacolgy. 2019, 148: 31-39.
    11. Xu MY, Wang P, Sun YJ, Wu YJ. Disruption of kidney metabolism in rats after subchronic combined exposure to low-dose cadmium and chlorpyrifos. Chem Res Toxicol. 2019, 32 (1):122–129.
    12. Jiang L, Wang P, Sun YJ, Wu YJ. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res. 2019, 38:265.
    13. Liang YJ, Wang P, Wang HP, Long DX, Sun YJ, Wu YJ. Time-course changes in urine metabolic profiles of rats following 90-day exposure to propoxur. Sci Rep. 2019, 9(1): e16989.
    14. Xu HY, Wang P, Sun YJ, Xu MY, Zhu L, Wu YJ. Activation of neuregulin 1/ErbB signaling is involved in the development of TOCP-induced delayed neuropathy. Front Mol Neurosci. 2018, 11:129.
    15. Xu HY，Wang P, Sun YJ, Jiang L, Xu MY, Wu YJ. Autophagy in tri-o-cresyl phosphate-induced delayed neurotoxicity. J Neuropathol Exp Neurol. 2017, 76 (1): 52-60.
    16. Xu MY, Wang P, Sun YJ, Yang L, Wu YJ. Joint toxicity of chlorpyrifos and cadmium on the oxidative stress and mitochondrial damage in neuronal cells. Food Chem Toxicol. 2017, 103: 246-252.
    17. Wang P, Wang J, Sun YJ, Yang L, Wu YJ. Cadmium and chlorpyrifos inhibit cellular immune response in spleen of rats. Environ Toxicol. 2017, 32: 1927-1936.
    18. Xu MY, Wang P, Sun YJ, Wu YJ. Metabolomic analysis for combined hepatotoxicity of chlorpyrifos and cadmium in rats. Toxicology. 2017, 384: 50-58.
    19. Wang P, Xu MY, Liang YJ, Wang HP, Sun YJ, Long DX, Wu YJ. Subchronic toxicity of low dose propoxur, permethrin, and their combination on the redox status of rat liver. Chem-Biol Interact. 2017, 272: 21-27.
    20. Long DX, Wang P, Sun YJ, Chen R, Wu YJ. Neuropathy target esterase is degraded by the ubiquitin-proteasome pathway with ARA54 as the ubiquitin ligase. Biochemistry. 2015, 54(50):7385-7392.
    21. Wang P, Wang Q, Yang L, Qin QL, Wu YJ. Characterization of lysophosphatidylcholine-induced changes of intracellular calcium in Drosophila S2 cells. Life Sci. 2015, 131: 57-62.
    22. Xu MY, Sun YJ, Wang P, Xu HY, Chen LP, Zhu L, Wu YJ. Metabolomics analysis and biomarker identification for brains of rats exposed subchronically to the mixtures of low-dose cadmium and chlorpyrifos. Chem Res Toxicol. 2015, 28 (6):1216-1223.
    23. Wang P, Wu YJ. Applications of metabonomics to pesticide toxicology. Curr Drug Metab. 2015, 16(3): 191-199.
    24. Wang P, Wang HP, Xu MY, Liang YJ, Sun YJ, Yang L, Li L, Li W, Wu YJ. Combined subchronic toxicity of dichlorvos with malathion or pirimicarb in mice liver and serum: a metabonomic study. Food Chem Toxicol 2014, 70:222-230.
    25. Luo L, Sun YJ, Yang L, Huang S, Wu YJ. Abamectin induces P-glycoprotein expression in S2 cells via calcium/calmodulin/NF-κB pathway. Chem-Biol Interact. 2013, 203:430-439.
    26. Chen JX, Sun YJ, Wang P, Long DX, Li W, Li L, Wu YJ. Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. Toxicology. 2013, 310:92-97.
    27. Luo L, Sun YJ, Wu YJ. Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGFR and dAkt pathways. Insect Biochem Mol Biol. 2013, 43:627-634.
    28. Zhu L, Wang P, Qin QL, Zhang H, Wu YJ. Protective effect of polypeptide from larva of housefly (Musca domestica) on hydrogen peroxide-induced oxidative damage in HepG2 cells. Food Chem Toxicol. 2013, 60:385-390.
    29. Sun YJ, Wang HP, Liang YJ, Yang L, Li W, Wu YJ. An NMR-based metabonomic investigation of the subacute effects of melamine in rats. J Proteome Res. 2012, 11: 2544-2550.
    30. Liang YJ, Wang HP, Long DX, Wu YJ. Applying biofluid metabonomic techniques to analyze the combined subchronic toxicity of propoxur and permethrin in rats. Bioanalysis. 2012, 4(24):2897-2907
    31. Wang Q, Wu YJ. Lysophosphatidylcholine induces Ca2+ mobilization in Jurkat human T lymphocytes and CTLL-2 mouse T lymphocytes by different pathways. Eur J Pharm Sci. 2011, 44: 602-609.
    32. Chen JX, Long DX, Hou WY, Li W, Wu YJ. Regulation of neuropathy target esterase by the cAMP/protein kinase A signal. Pharmacol Res. 2010,62: 259-264.
    33. Chang PA, Wu YJ. Neuropathy target esterase: An essential enzyme for neural development and axonal maintenance, Int J Biocehm Cell Biol. 2010, 42:573-575.
    34. Long DX, Chang PA, Liang YJ, Yang L, Wu YJ. Degradation of neuropathy target esterase by macroautophagic lysosomal pathway. Life Sci. 2009, 84:89-96.
    35. Li Q, Wu YJ. A fluorescent, genetically engineered micro-organism that degrades organophosphates and commits suicide when required. Appl Microbiol Biotechnol. 2009, 82:749-756.
    36. Liu CY, Chang PA, Wu YJ. Trichlorfon induces apoptosis in SH-SY5Y neuroblastoma cells via the endoplasmic reticulum? Chem-Biol Interact. 2009, 181:37-44.
    37. Hou WY, Long DX, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine in nervous tissues of mice was not disrupted after administration of tri-o-cresyl phosphate. Toxicol Sci. 2009, 109:276-285.
    38. Long DX, Wu YJ. Growth inhibition and induction of G1 phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate. Toxicol Lett. 2008, 181:47-52.
    39. Hou WY, Long DX, Wang HP, Wang Q, Wu YJ. The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate induced delayed neurotoxicity in hens. Toxicology. 2008, 252:56-63.
    40. Li XH, Wu YJ. Characteristics of lysophosphatidylcholine-induced Ca2+ response in human neuroblastoma SH-SY5Y cells. Life Sci. 2007, 80:886-892.
    41. Chen R, Chang PA, Liu CY, Yang L, Wu YJ. G protein β2 subunit interacts directly with neuropathy target esterase and regulates its activity. Int J Biochem Cell Biol. 2007, 39:124-132.
    42. Wu YJ, Li M, Li YX, Li W, Dai JY, Leng XF. Verapamil abolished the enhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate. Environ Toxicol Pharmacol. 2007, 24:67-71.
    43. Li XH, Long DX, Li W, Wu YJ. Different mechanisms of lysophosphotidylcholine-induced Ca2+ mobilization in N2a mouse and SH-SY5Y human neuroblastoma cells. Neurosci Lett. 2007, 424:22-26.
    44. Chang PA, Wu YJ, Li W, Leng XF. Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. Chem-Biol Interact. 2006, 159: 65-72.
    45. Chang PA, Chen R, Wu YJ. Over-expression of neuropathy target esterase inhibits mammalian cell proliferation. Cell Proliferat. 2006, 39: 429-440.