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  Principal Investigators
Cell Biology
+86-10-64807321  /  +86-10-64807321
State Key Laboratory of Membrane Biology , Institute of Zoology, Chinese Academy of Siences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Group of Apoptosis and Cancer Biology      

Dr.  Quan Chen got his Ph.D. from Institute of Zoology, CAS, and had post-doctoral trainings in Manchester University, UK (1994-1997) and in Cleveland Clinic Foundation, Ohio, USA (1997-2000). He has won the National Outstanding Young Scientist Award, Changjiang Scholarship, Tan Jiazhen award for innovative research in bioscience and National outstanding investigator award. Dr. Chen has served as the Director and associate Director of the State Key Laboratory of Biomembrane and Membrane Biotechnology (2001-2011). He is the executive member of the Chinese Society of Biophysics and Cell Biology, associate director of the Society of Biomembrane and Cell Biology in Chinese Society of Biophysics and vice president of Asia Society of Mitochondrial Research and Medicine. Dr. Chen currently serves as an associate editor of Cell Death Discovery, editor for FEBS Letters, editorial member in Cell Research, JBC and other national journals.

The research in Dr. Chen’s laboratory focuses on mitochondrial biology and cancer stem cells. In particular, he wishes to understand the molecular regulation of mitochondrial apoptosis, the molecular regulation of mitochondrial autophagy and mitochondrial dynamics with aims to understand the molecular mechanism of aging related diseases such as cancers, metabolic disorders and neurodegenerative disorders.

Research Interests:

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Selected Publications:
  1. Ma B, Cheng H, Chen L, Mu C, Gao R, Wu S, Chen Q, Zhu Y*. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signaling pathways. Nature Communicatio, 7:11123, 2016.
  2. Chen M, Chen ZH, Wang YY, Tan Z, Zhu CZ, Li YJ, Han Z, Chen LB, Gao RZ, Liu L*, Chen Q*. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy, 12(4):1-14, 2016
  3. Li J, Qi W, Chen G, Feng D, Liu J, Ma B, Zhou C, Mu C, Zhang W, Chen Q*, Zhu Y*. Mitochondrial outer-membrane E3 ligase MUL1 ubiqutinates ULK1 and regulates selenite-induced mitophagy. Autophagy, 11(8): 1216-1229, 2015. (2015.08)
  4. Wei H, Liu L, Chen Q*. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Biochimica et Biophysica Acta-Molecular Cell Research, 1853(10):2784-2790, 2015.
  5. Huang L, Han J, Ben-Hail D, He LW, Li B, Chen ZH, Wang YY, Yang YL, Liu L, Zhu YS, Shoshan-Barmatz V*, Liu HW*, Chen Q*. A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells. Journal of Biological Chemistry, 290(39): 23563-23578, 2015.  (2015.09.25)
  6. Wu H, Chen Q*. Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis. Antioxidants & Redox Signaling, 22(12):1032-1046, 2015.
  7. Ma B, Chen Y, Chen L, Cheng HC, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J , Zhu Y*, Chen Q*, Wu S* Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase. Nature Cell Biology, 17(1):95–103, 2015.
  8. Liu L, Sakakibara K, Chen Q*, Okamoto K* Receptor-mediated mitophagy in yeast and in mammalian systems, Cell Research. 24(7):787-795, 2014. (invited review)
  9. Wu H, Xue DF, Chen G, Han Z, Huang L, Zhu.CZ, Wang XH, Jin HJ, Wang J, Zhu YS, Liu L, Chen Q*. The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy, 10(10): 1712–25, 2014.
  10. Chen G, Han Z., Feng D, Chen YF, Chen LB, Wu H, Huang L, Zhou CQ, Cai XY, Fu CY, Duan LW, Wang XH, Liu L, Liu XQ, Shen YQ, Zhu YS*, Chen, Q*. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Molecular Cell, 54: 362-377, 2014.
  11. Yue W, Chen ZH, Liu HY, Yan C, Chen M, Feng D, Yan C, Wu H, Du L, Wang YY, Liu JH, Huang XH, Xia LX, Liu L., Wang XH., Jin HJ, Wang J, Song ZY, Hao XJ*, Chen Q*. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Research, 24(4):482-96, 2014.
  12. Du L, Rao G, Wang H, Li B, Tian W, Cui JT, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y*, Chen Q*.(2013) CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer, Cancer Research, 73(8): 2682-2694 (cover).
  13. Liu Y, Cheng H, Zhou Y, Zhu Y, Bian R, Chen Y, Li C, Ma Q, Zheng Q, Zhang Y, Jin H, Wang X, Chen Q*, Zhu D* (2013) Myostatin induces mitochondrial metabolic alteration and typical apoptosis in cancer cells, Cell Death and Disease, e494, 2013.
  14. Rao G, Wang H, Li B, Huang L, Xue D, Wang X, Jin H, Wang J, Zhu Y, Lu Y, Du L*, Chen Q*, (2013)Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer. Clinical Cancer Research.2013,Feb.15, 19(4):785-97
  1. Lei Liu, Du Feng, Guo Chen, Ming Chen, Qiaoxia Zheng, Pingping Song, Qi Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi, Lei Huang, Peng Xue, Baowei Li, Xiaohui Wang, Haijing Jin, Jun Wang, Fuquan Yang, Pingsheng Liu, Yushan Zhu, Senfang Sui & Quan Chen*,(2012)Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells,Nature Cell Biology, 2012, Feb 14 (2):177-185
  2. Lixia Zhao, Feng He, Haiyang Liu, Yushan Zhu1, Weili Tian, Ping Gao, Hongping He, Wen Yue, Xiaobo Lei, Biyun Ni, Xiaohui Wang, Haijing Jin, Xiaojiang Hao, *, Jialing Lin, *, and Quan Chen,*(2012) A natural compound elevates expression of Bim that interacts with Bcl-2 converting the anti-apoptotic protein to a pro-apoptotic Bax-like molecule. Journal of Biological Chemistry,2012 Jan; 287(2): 1054-65
  3. Zhu YS , Li M, Wang XH, Jin HJ, Liu SS, Xu JX*, Chen Q* (2012) Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release, Cell Research, 2012, 22(1) :127-141.
  4. Ni B, Ma Q, Li B, Zhao L, Liu Y, Zhu Y, and Chen Q* (2012) Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells Through Upregulation of Bim. Clinical Cancer Research, 2012 Jan, 18:140-151
  5. Ma Q, Fang HQ, Shang W, Liu L, Xu ZS, Ye T, Wang XH, Zheng M*, Chen Q* and Cheng HP* (2011) Superoxide flashes: early mitochondrial signals for oxidative stress induced apoptosis Journal of Biological Chemistry, 2011 Aug; 286(31): 27573-81
  6. Wang HX, Song PP, Du L, Tian WL, Yue W, Liu M, Li DW, Wang B, Zhu YS, Zhou J*, Chen Q* (2011)Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson’s disease. Journal of Biological Chemistry,2011 Apr 1; 286(13):11649-58
  7. Zhang J., Liu WH, Liu JC, Xiao WM, Liu L, Jiang CS, Sun X, Liu PS, Zhu YS, Zhang CM, and Chen Q* (2010) G protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion.  Nature Communications, 1, 101-110
  8. Zhao L, Zhu YS* Wang DM, Chen M, Gao P, Xiao WM, Rao GH Wang XH, Jin J, Xu L, Sui N, * and Chen Q* (2010) Morphine induces Beclin 1- and ATG5 dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus. Autophagy ,2010 Apr;6(3):386-94
  9. Shang YL, Liu Y, Du L, Wang YL, Cheng X, Xiao WM, Wang XH, Jin HJ, Yang X, Liu SS and Chen Q*(2009) Targeted Expression of Uncoupling Protein 2 to Mouse Liver Increases the Susceptibility to LPS/GalN-Induced Acute Liver Injury. Hepatology, 50(4):1204-16
  10. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y*, Chen Q*(2008) CD44 is of functional importance for colorectal cancer stem cell. Clinical Cancer research, 14, 6751-6760
  11. Nie C, Tian C, Zhao L, Petit P, Mehrpour M and Chen Q (2008) Cysteine 62 of Bax is critical for its conformational activation and its pro-apoptotic activity in response to H2O2 -induced apoptosis. Journal of Biological Chemistry, 283(22):15359-15369
  12. Lei XB, Chen YY, DuGH, Yu WY, Wang XH, Qu H, Xia B, He HP, Mao JH, Zong WX, Mehrpour M, Hao XJ and Chen Q*(2006)Bak/Bax activation and mPTP opening independent cytochrome c release and apoptosis induced by gossypol which triggers Bcl-2 conformational change, FASEB J, 20: 2147-2149
  13. Liao XD, Liu,JM Du L, Tang AH, Wang SQ, Chen LY*, Chen Q* (2006) Nitric Oxide Signaling in Stretch-induced Apoptosis of Neonatal Rat Cardiomyocytes, FASEB J, 20: 1883-1885
  14. Zheng YH., Tian CH, Wang HG, Chen Q. (2005) Arsenic trioxide induces apoptosis through activation of Bax in hematopoietic cells , Oncogene, 24:3339-3347)
  15. Zheng YH., Shi R., Jiang CH., Tang H., Chen Q* (2004) The mitochondrial Voltage-Dependent Anion Channel (VDAC) plays an essential rolein Arsenic Trioxide-Induced cytochrome c release and apoptosis in multiple myeloma cells, Oncogene 23:1239-1247