Location: Home > Scientists
  Principal Investigators
Name:
 LIU Changmei
Subject:
 Developmental Biology
Tel/Fax:
 +86-10-82619690  / 
E-mail:
 liuchm@ioz.ac.cn
Address:
 No. 3A Datun Rd, Chaoyang District, Beijing 100101, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, CAS
More:
 Group of Stem Cell and Neurological Diseases      
Resume:
Dr. Chang-Mei Liu received her Ph.D from Peking Union Medical College in 2004. From 2004 to 2008, she worked at the Institute of Microbiology, Chinese academy of Sciences as an Assistant /Associate Professor. She then did her postdoctoral training in the Department of Neuroscience at the University of New Mexico and the Johns Hopkins University School of Medicine. Dr. Liu has established her independent research group at the State Key Laboratory of Stem Cell and Reproductive Biology (IOZ, CAS) since 2015, and she is a Professor of Stem Cell and Neuroscience at the Institute of Zoology (IOZ), Chinese academy of Sciences (CAS). She currently serves as a reviewer for some international journals such as Bioscience, Stem Cells and Development, Journal of Molecular Neuroscience, Molecular Medicine, and Cellular Reprogramming.

Research Interests:
Research interest of Dr. Liu has been focused on epigenetic mechanisms underlying mammalian neurogenesis and mental disorders by utilizing technologies in molecular biology, cell biology, biochemistry, epigenetics, virology, histology, confocal imaging, mouse genetics and animal behaviors. Specifically, her group is interested in understanding: 1) what functions of histone modifications are in the fate choice of neural stem cells and maturation of new born neurons, and how neurons connect during development; 2) how the neural activity influences the behavior of neural stem cells; 3) how to realize the therapeutic potentials of neural stem cells in mental diseases; and 4) translational research of stem cell therapy for neurological disorder and nerve injury.

Awards and Honors:

Professional Activities:

Research Grants:
  • 2015-2018, Institute of Zoology, Chinese Academy of Sciences, PI.
  • 2016-2019, Functions of H3K27 De-methylation in Neuronal Maturation and Cognition, National Basic Research Program of China, PI.
  • 2018-2021, The Function and Mechanism of Chromatin Remodeling Gene ARID1A in the Development of Hippocampus and Intelligence in Mice. National Basic Research Program of China, PI
  • 2018-2020, The Roles and Mechanism of H3K27me3 and Associated Demethylase UTX/JMJD3 in Optic Nerve Regeneration and Vision Restoration. National Basic Research Program of China, PI.
  • 22016-2020, National Key Research and Development Program of China Project, PI.

Selected Publications:
  1. Ma JJ, Ju X, Xu RJ, Wang WH, Luo ZP, Liu CM, Zhou FQ, Saijilafu. Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc. J Neurosci. 2019 Nov 13;39(46):9107-9118.
  2. Xi F, Xu RJ, Xu JH, Ma JJ, Wang WH, Liu CM, Yang HL, Meng B, Saijilafu. Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone. J Cell Physiol. 2019 Dec;234(12):23053-23065.
  3. Zhang SF, Gao J, Liu CM#. The Role of Non-Coding RNAs in Neurodevelopmental Disorders. Front Genet. 2019 Nov 20;10:1033.
  4. Yan HL, Sun XW, Wang ZM, Liu PP, Mi TW, Liu C, Wang YY, He XC, Du HZ, Liu CM#, Teng ZQ#. MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice. Front Mol Neurosci. 2019 Oct 30; 12:260.
  5. Xu YJ*, Liu PP*, Ng SC, Teng ZQ, Liu CM#. Regulatory Networks between Polycomb Complexes and Non-coding RNAs in Central Nervous System. J Mol Cell Biol. 2019 Jul 10. pii: mjz058 (*Co-first author).
  6. Liu C*, Dai SK*, Sun Z, Wang Z, Liu PP, Du HZ, Yu S, Liu CM#, Teng ZQ#. GA-binding protein GABPβ1 is required for the proliferation of neural stem/progenitor cells. Stem Cell Res. 2019 Aug; 39:101501(*Co-first author).
  7. Liu PP*, Xu YJ*, Dai SK, Du HZ, Wang YY, Li XG, Teng ZQ, Liu CM#. Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus. Stem Cell Reports. 2019 Jul 9;13(1):115-131(*Co-first author).
  8. Cheng Y*, Wang ZM*, Tan W*, Wang X*, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, et al. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nat Neurosci. 2018 Dec;21(12):1689-1703(*Co-first author).
  9. Duan RS*, Tang GB*, Du HZ*, Hu YW, Liu PP, Xu YJ, Zeng YQ, Zhang SF, Wang RY, Teng ZQ, Liu CM#. Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration. Cell Death and Differentiation. 2018 Sep;25(9):1598-1611(*Co-first author).
  10. Liu PP*, Xu YJ*, Teng ZQ, Liu CM#. Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. Neuroscientist. 2018 Jun;24(3):208-220(*Co-first author).
  11. Tang GB*, Zeng YQ*, Liu PP*, Mi TW, Zhang SF, Dai SK, Tang QY, Yang L, Xu YJ, Yan HL, Du HZ, Teng ZQ, Zhou FQ, Liu CM#. The histone h3k27 demethylase utx regulates synaptic plasticity and cognitive behaviors in mice. Front Mol Neurosci, 2017, 10:267(*Co-first author).
  12. Liu PP, Tang GB, Xu YJ, Zeng YQ, Zhang SF, Du HZ, Teng ZQ#, Liu CM#. MiR-203 Interplays with polycomb repressive complexes to regulate the proliferation of neural stem/progenitor cells. Stem Cell Reports. 2017,9(1):190-202.
  13. Li P, Teng ZQ, Liu CM#. Extrinsic and intrinsic regulation of axon regeneration by micrornas after spinal cord injury. Neural Plasticity, 2016:1279051.
  14. Jiang JJ*, Liu CM*, Zhang BY, Wang XW, Zhang M, Saijilafu, Zhang SR, Hall P, Hu YW, Zhou FQ. MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression. Cell Death and Disease. 2015, 6: e1865 (*Co-first author).
  15. Liu CM*, Wang RY*, Saijilafu, Jiao ZX, Zhang BY, Zhou FQ. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev. 2013, 27(13):1473-83(*Co-first author).
  16. Liu CM*, Teng ZQ*, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010, 6(5):433-44 (*Co-first author).
  17. Saijilafu, Hur EM, Liu CM, Jiao ZX, Xu WL, and Zhou F-Q. PI3K-GSK3 pathway regulates mammalian axon regeneration by induction of Smad1. Nature Communications, 2013, 4:2690.
  18. Guo W, Zhang Li, Christopher DM, Teng ZQ, Fausett SR, Liu CM, George OL, Klingensmith J, Jin P, Zhao X. RNA binding protein FXR2 regulates proliferation and differentiation of adult hippocampal neural stem cells by repressing Noggin expression. Neuron, 2011, 70:924-938.
  19. Liu CM, Teng ZQ, McQuate AL, Jobe EM, Christ CC, Hoyningen-Huene SJ, Reyes MD, Polich ED, Xing Y, Li Y, Guo W, Zhao X. An Epigenetic Feedback Regulatory Loop Involving MicroRNA-195 and MBD1 Governs Neural Stem Cell Differentiation PLoS One. 2013,8(1): e51436.
  20. Cong HL, Sun LQ, Liu C, Tien P. bition of atrogin-1/MAFbx expression by adenovirus-delivered small hairpin RNAs attenuates muscle atrophy in fasting mice. Hum Gene Ther. 2011 Mar;22(3):313-24.
  21. Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008, 283 (41):27644-77652.
  22. Luo Y, Shan G, Guo W, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X. Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010, 8;6(4): e1000898.
  23. Liu CM, Zhao XY. MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med. 2009,11 (3):141-152.
  24. Liu CM, Yang Z, Liu CW, Wang R, Tien P, Dale R, Sun LQ. Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice. Gene Ther. 2008, 15 (3):155-160.
  25. Gong H, Liu CM, Liu DP, Liang CC. The role of small RNAs in human diseases: potential troublemaker and therapeutic tools. Med Res Rev. 2005, 25(3):361-381.
  26. Ke XS, Liu CM, Liu DP, Liang CC. MicroRNAs: key participants in gene regulatory networks. Curr Opin Chem Biol. 2003 7(4):516-523.