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  Principal Investigators
+86-10-64807178  / 
The State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China
Group of Vector-Arbovirus Interaction      
  • 2015-present   Professor, Institute of Zoology,Chinese Academy of Sciences.   
  • 2013-2014    Associate, Albert Einstein College of Medicine, Bronx, NY                               
  • 2008-2013    Research Fellow, Albert Einstein College of Medicine, Bronx, NY                                                   
  • 2001-2007    Research Assistant, Peking University, Beijing, China
  • Ph.D. in Cell Biology, 2007, Peking University, P.R.China
  • B.S. in Biochemistry, 2001, Nankai University, P.R.China

Research Interests:

Arbovirus is transmitted by blood-sucking arthropod, currently it’s an international disaster to public health. Our lab is focusing on the transmission circle of virus-vector-host using dengue virus as a model. We are trying to understand the infection and transmission mechanism by studying the entry and exit mechanism of dengue virus using molecular biological, virological, biochemistry and entomological strategies. We are trying to discover new strategy for dengue control especially on the vector level.        

  1. Virus entry and exit mechanism, especially the molecular mechanism of virus assembly and budding.
  2. The molecular mechanism of virus entry of the mosquito midgut.
  3. How the virus escapes the vector immune system。

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Zheng A, Yuan F, Kielian M. Toggle-Switch that Controls the Low pH-Triggered Rearrangement and Maturation of the Dengue Virus Envelope Proteins. Nature Communication, in press.
  2. Zheng A, Umashankar M, Kielian M. In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions. PLOS Pathogen. 2010; 6(10), e1001157
  3. Zheng A, Yuan F, Yanqin Li, Fangfang Zhu, Pingping Hou, Jianqing Li, Xijun Song, Ding M, Deng H. Claudin-6 and Claudin-9 Function as Additional co-Receptors for Hepatitis C Virus. J Virol 2007; 81(22), 12465-71
  4. Wang P*, Chen J*, Zheng A*, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M, Deng H. Expression cloning of functional receptor used by SARS coronavirus. (*These author contributed equally to the article) Biochem Biophys Res Commun. 2004; 315(2),439-444
  5. Wang L*, Zheng A*, Yi L, Xu C, Ding M, Deng H. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. (*These author contributed equally to the article) Biochem Biophys Res Commun. 2004; 325(1), 302-327
  6. Liao M, Sánchez-San Martín C, Zheng A, Kielian M. In vitro reconstitution reveals key intermediate states of trimer formation by the dengue virus membrane fusion protein. J Virol. 2010; 84(11), 5730
  7. Qu XX, Hao P, Song XJ, Jiang SM, Liu YX, Wang PG, Rao X, Song HD, Wang SY, Zuo Y, Zheng AH, Luo M, Wang HL, Deng F, Wang HZ, Hu ZH, Ding MX, Zhao GP, Deng HK. Identification of two critical amino acid residues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy. J Biol Chem. 2005; 280(33), 29588-29595


  1. Margaret Kielian and Aihua Zheng.  Methods for preventing or treating viral infection. Patent application number   # PCT/US11/00241, February 12, 2010.